Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Carrier)

Inclusion Criteria:

• Diagnosis of probable AD

• Age from 50 to less than 89

• Mini-Mental Status Exam score of 16-26 inclusive

• Brain magnetic resonance imaging (MRI) scan consistent with the diagnosis of AD

• Stable doses of medications (cholinesterase inhibitors and memantine allowed)

• Caregiver able to attend all clinic visits with patient

Exclusion Criteria:

• Significant neurological disease other than AD

• Major psychiatric disorder

• Significant systemic illness

• History of stroke or seizure, autoimmune disease, myocardial infarction within thelast 2 years

• Smoking greater than 20 cigarettes per day

• Anticonvulsants, anti-Parkinson's, anticoagulant, or narcotic medications

• Prior treatment experimental immunotherapeutics or vaccines for AD

• Women of childbearing potential

• Presence of pacemakers, CSF shunts, or foreign metal objects in the eyes, skin or body