Optical Sensor for Photodynamic Detection of Oral Pathology

Last updated: January 14, 2025
Sponsor: University of California, Irvine
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

detection of oral pathology

Clinical Study ID

NCT00540774
20022805
LDG
R03EB014852
R01DE022831
R44CA265514
UCI-08-52
T31IR1825
OE
  • Ages 18-75
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Overall objective of this work is to develop better ways of detecting, diagnosing and measuring oral diseases and structures using light and optical approaches. All different areas of the mouth will be imaged, including healthy, diseased, dysplastic and malignant, as well as oral biofilm, and the imaging data compared against conventional diagnostic approaches such clinical and histopathological and molecular evaluations to (1) gain a better understanding of processes involved in oral pathology and (2) develop a combined patient specific, non-invasive method for the detection, diagnosis and screening of oral pathology and biofilm. Thus our goal is to identify and evaluate microstructural, metabolic, vascular, protein, genomic and metabolomics biomarkers of oral pathology can be used to detect, predict and map oral pathology, especially neoplasia.

We are recruiting patients with a wide range of oral conditions including plaque, dry mouth, toothache, root canal treatments, gum disease, oral sores, dysplasia and cancer, autoimmune conditions and others as well as healthy control subjects. We will use a range of non-invasive imaging modalities to obtain information on the ways in which the oral health status affects optical properties, and determine means of detecting and quantifying these factors.. Imaging modalities to be utilized include:

  1. Coherence and Doppler Tomography

  2. Laser Speckle Imaging

  3. Various forms of Spectroscopy

  4. Fluorescence

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male or Female age 18 years and older

  • Have oral lesion or not have oral lesion

  • Have condition of dry mouth

  • Have condition of Gum disease

  • Non-smoker

Exclusion

Exclusion Criteria:

  • Age less than 18 years old

  • Advanced gum disease, diseases of oral tissue

  • Untreated cavities

  • Pregnant or breastfeeding

  • Immune compromised individuals

Study Design

Total Participants: 2500
Treatment Group(s): 1
Primary Treatment: detection of oral pathology
Phase:
Study Start date:
April 01, 2003
Estimated Completion Date:
December 31, 2028

Study Description

Purpose of the research is to identify optical predictors and biomarkers of health and disease.

Hypothesis: microstructural, metabolic, vascular, protein, genomic and metabolomics biomarkers of oral pathology can be used to detect, predict and map oral pathology, especially neoplasia.

Researchers of the Beckman Laser Institute (BLI) have developed many non-invasive imaging modalities for assessment of oral tissue. This protocol will allow data acquisition with these multiple modalities to allow validation of data. Imaging modalities to be utilized include:

  1. Coherence and Doppler Tomography (OCT)

  2. Laser Speckle Imaging (LSI)

  3. Photon Migration Spectroscopy (PMS)

  4. Autofluorescence Imaging

In addition, saliva samples from the patients will be analyzed and the resulting data regarding the dysregulation in the activities of genes, proteins and other molecules will be correlated with findings from different imaging systems with respect to the stage of oral carcinogenesis.

Connect with a study center

  • Beckman Laser Institute and Medical Clinic

    Irvine, California 92612
    United States

    Active - Recruiting

  • Beckman Laser Institute, University of California Irvine

    Irvine, California 92612
    United States

    Active - Recruiting

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