Optical Sensor for Photodynamic Detection of Oral Pathology

Phase

N/A

Condition

Dry Mouth

Periodontitis

Saliva And Salivary Gland Dysfunction

Treatment

detection of oral pathology

Clinical Study ID

NCT00540774

20022805

LDG

R03EB014852

R01DE022831

R44CA265514

UCI-08-52

T31IR1825

Ages 18-75
All Genders
Accepts Healthy Volunteers

Study Summary

Overall objective of this work is to develop better ways of detecting, diagnosing and measuring oral diseases and structures using light and optical approaches. All different areas of the mouth will be imaged, including healthy, diseased, dysplastic and malignant, as well as oral biofilm, and the imaging data compared against conventional diagnostic approaches such clinical and histopathological and molecular evaluations to (1) gain a better understanding of processes involved in oral pathology and (2) develop a combined patient specific, non-invasive method for the detection, diagnosis and screening of oral pathology and biofilm. Thus our goal is to identify and evaluate microstructural, metabolic, vascular, protein, genomic and metabolomics biomarkers of oral pathology can be used to detect, predict and map oral pathology, especially neoplasia.

We are recruiting patients with a wide range of oral conditions including plaque, dry mouth, toothache, root canal treatments, gum disease, oral sores, dysplasia and cancer, autoimmune conditions and others as well as healthy control subjects. We will use a range of non-invasive imaging modalities to obtain information on the ways in which the oral health status affects optical properties, and determine means of detecting and quantifying these factors.. Imaging modalities to be utilized include:

Coherence and Doppler Tomography
Laser Speckle Imaging
Various forms of Spectroscopy
Fluorescence

Eligibility Criteria

Inclusion

Inclusion Criteria:

Male or Female age 18 years and older
Have oral lesion or not have oral lesion
Have condition of dry mouth
Have condition of Gum disease
Non-smoker

Exclusion

Exclusion Criteria:

Age less than 18 years old
Advanced gum disease, diseases of oral tissue
Untreated cavities
Pregnant or breastfeeding
Immune compromised individuals

Study Design

detection of oral pathology

April 01, 2003

March 03, 2026

Study Description

Purpose of the research is to identify optical predictors and biomarkers of health and disease.

Hypothesis: microstructural, metabolic, vascular, protein, genomic and metabolomics biomarkers of oral pathology can be used to detect, predict and map oral pathology, especially neoplasia.

Researchers of the Beckman Laser Institute (BLI) have developed many non-invasive imaging modalities for assessment of oral tissue. This protocol will allow data acquisition with these multiple modalities to allow validation of data. Imaging modalities to be utilized include:

Coherence and Doppler Tomography (OCT)
Laser Speckle Imaging (LSI)
Photon Migration Spectroscopy (PMS)
Autofluorescence Imaging

In addition, saliva samples from the patients will be analyzed and the resulting data regarding the dysregulation in the activities of genes, proteins and other molecules will be correlated with findings from different imaging systems with respect to the stage of oral carcinogenesis.

Connect with a study center

Beckman Laser Institute and Medical Clinic
Irvine, California 92612
United States
Site Not Available

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