Pregabalin Versus Levetiracetam In Partial Seizures

Last updated: January 26, 2021
Sponsor: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Overall Status: Completed

Phase

3

Condition

Seizure Disorders (Pediatric)

Treatment

N/A

Clinical Study ID

NCT00537238
A0081157
  • Ages > 18
  • All Genders

Study Summary

This study will compare pregabalin and levetiracetam in patients with partial seizures. It will also evaluate the safety and tolerability of pregabalin and levetiracetam in these patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Subjects (male or female) must be > 18 years of age, with a diagnosis of epilepsy withpartial seizures, as defined in the International League Against Epilepsy (ILAE)classification of seizures.
  • Partial seizures may be simple or complex, with or without secondary tonic-clonicgeneralization.
  • Subjects must be have been diagnosed with epilepsy for at least 2 years, and must havebeen unresponsive to treatment with at least two but no more than five priorantiepileptic drugs (AEDs), and at the time of study enrollment are on stable dosagesof 1 or 2 standard AEDs.

Exclusion

Exclusion Criteria:

  • Females who are pregnant, breastfeeding, or intend to become pregnant during thecourse of the trial will be excluded
  • Subjects with other neurologic illness that could impair endpoint assessment, orsubjects with Lennox-Gastaut syndrome, absence seizures, status epileptics within the 12 months prior to trial entry, or with seizures due to an underlying medical illnessor metabolic syndrome, will be excluded.

Study Design

Total Participants: 509
Study Start date:
October 01, 2007
Estimated Completion Date:
May 31, 2012

Connect with a study center

  • Pfizer Investigational Site

    Duffel, B-2570
    Belgium

    Site Not Available

  • Pfizer Investigational Site

    Yvoir, B-5530
    Belgium

    Site Not Available

  • Pfizer Investigational Site

    Kyustendil 2500,
    Bulgaria

    Site Not Available

  • Pfizer Investigational Site

    Pernik, 2300
    Bulgaria

    Site Not Available

  • Pfizer Investigational Site

    Plovdiv, 4000
    Bulgaria

    Site Not Available

  • Pfizer Investigational Site

    Ruse 7002,
    Bulgaria

    Site Not Available

  • Pfizer Investigational Site

    Sofia, 1407
    Bulgaria

    Site Not Available

  • Pfizer Investigational Site

    Barranquilla, Atlantico 0
    Colombia

    Site Not Available

  • Pfizer Investigational Site

    Bogota, Cundinamarca 0
    Colombia

    Site Not Available

  • Pfizer Investigational Site

    Montes De Oca, San Jose
    Costa Rica

    Site Not Available

  • Pfizer Investigational Site

    San Jose,
    Costa Rica

    Site Not Available

  • Pfizer Investigational Site

    Brno, 602 00
    Czechia

    Site Not Available

  • Pfizer Investigational Site

    Brno 2, 602 00
    Czechia

    Site Not Available

  • Pfizer Investigational Site

    Hradec Kralove 3, 500 03
    Czechia

    Site Not Available

  • Pfizer Investigational Site

    Olomouc, 775 20
    Czechia

    Site Not Available

  • Pfizer Investigational Site

    Ostrava-Trebovice, 772 00
    Czechia

    Site Not Available

  • Pfizer Investigational Site

    Praha 4, 140 59
    Czechia

    Site Not Available

  • Pfizer Investigational Site

    Pribram 8, 26195
    Czechia

    Site Not Available

  • Pfizer Investigational Site

    Rychnov nad Kneznou, 516 01
    Czechia

    Site Not Available

  • Pfizer Investigational Site

    Strasbourg Cedex, 67091
    France

    Site Not Available

  • Pfizer Investigational Site

    Toulouse, 31043
    France

    Site Not Available

  • Pfizer Investigational Site

    Bonn, 53105
    Germany

    Site Not Available

  • Pfizer Investigational Site

    Hamburg, 22083
    Germany

    Site Not Available

  • Pfizer Investigational Site

    Athens, 11521
    Greece

    Site Not Available

  • Pfizer Investigational Site

    Thessaloniki, 57010
    Greece

    Site Not Available

  • Pfizer Investigational Site

    Pune, Maharashtra 411 004
    India

    Site Not Available

  • Pfizer Investigational Site

    Chandigarh, Punjab 160 012
    India

    Site Not Available

  • Pfizer Investigational Site

    Ludhiana, Punjab 141 008
    India

    Site Not Available

  • Pfizer Investigational Site

    Firenze, 50125
    Italy

    Site Not Available

  • Pfizer Investigational Site

    Foggia, 71100
    Italy

    Site Not Available

  • Pfizer Investigational Site

    Pisa, 56126
    Italy

    Site Not Available

  • Pfizer Investigational Site

    Siena, 53100
    Italy

    Site Not Available

  • Pfizer Investigational Site

    Busan, 602-715
    Korea, Republic of

    Site Not Available

  • Pfizer Investigational Site

    Daejeon, 301-721
    Korea, Republic of

    Site Not Available

  • Pfizer Investigational Site

    Seoul, 135-710
    Korea, Republic of

    Site Not Available

  • Pfizer Investigational Site

    Kaunas, 50009
    Lithuania

    Site Not Available

  • Pfizer Investigational Site

    Vilnius, 08661
    Lithuania

    Site Not Available

  • Pfizer Investigational Site

    Distrito Federal, 14269
    Mexico

    Site Not Available

  • Pfizer Investigational Site

    San Luis Potosi, 78223
    Mexico

    Site Not Available

  • Pfizer Investigational Site

    Panama,
    Panama

    Site Not Available

  • Pfizer Investigational Site

    Lima, Lima 1
    Peru

    Site Not Available

  • Pfizer Investigational Site

    Tondo, Manila 1000
    Philippines

    Site Not Available

  • Pfizer Investigational Site

    Cebu City, 6000
    Philippines

    Site Not Available

  • Pfizer Investigational Site

    Davao City, 8000
    Philippines

    Site Not Available

  • Pfizer Investigational Site

    Makati City, 1200
    Philippines

    Site Not Available

  • Pfizer Investigational Site

    Manila, 1000
    Philippines

    Site Not Available

  • Pfizer Investigational Site

    Quezon City, 1100
    Philippines

    Site Not Available

  • Pfizer Investigational Site

    Moscow, 129128
    Russian Federation

    Site Not Available

  • Pfizer Investigational Site

    St. Petersburg, 194044
    Russian Federation

    Site Not Available

  • Pfizer Investigational Site

    Donostia, Guipuzcoa 20014
    Spain

    Site Not Available

  • Pfizer Investigational Site

    Alicante, 03010
    Spain

    Site Not Available

  • Pfizer Investigational Site

    Barcelona, 08035
    Spain

    Site Not Available

  • Pfizer Investigational Site

    Cordoba, 14008
    Spain

    Site Not Available

  • Pfizer Investigational Site

    Girona, 17007
    Spain

    Site Not Available

  • Pfizer Investigational Site

    Sevilla, 41071
    Spain

    Site Not Available

  • Pfizer Investigational Site

    Kaohsiung, 807
    Taiwan

    Site Not Available

  • Pfizer Investigational Site

    Taichung, 407
    Taiwan

    Site Not Available

  • Pfizer Investigational Site

    Tainan, 704
    Taiwan

    Site Not Available

  • Pfizer Investigational Site

    Capa, Istanbul 34390
    Turkey

    Site Not Available

  • Pfizer Investigational Site

    Ankara, 06100
    Turkey

    Site Not Available

  • Pfizer Investigational Site

    Cerrahpasa / Istanbul, 34098
    Turkey

    Site Not Available

  • Pfizer Investigational Site

    Caracas, Miranda 1080-A
    Venezuela

    Site Not Available

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