Herbal Treatment for Perennial Allergic Rhinitis

Last updated: November 23, 2009
Sponsor: Chinese University of Hong Kong
Overall Status: Completed

Phase

2

Condition

Allergy

Rhinitis, Allergic, Perennial

Common Cold

Treatment

N/A

Clinical Study ID

NCT00456755
ICM/CTS/03/333
  • Ages 18-65
  • All Genders

Study Summary

Allergic rhinitis(AR) is one of the most common allergic disorders throughout the world.The conventional therapies are effective in alleviating symptoms but the efficacy are limited and not persistent. Furthermonre, the cost and side-effect are known defects. A classical Chinese herbal formula, has been used for AR for centries. Our study purpose is to evaluate the clinical efficacy and safety of this formula verus placebo in perennial allergic rhinitis (PAR).

Hypothesis: the classical herbal formula would improve the symptoms of PAR patients and change some immunological parameters in the peripheral blood when comparing with the placebo.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged from 18 to 65 years old

  • Have typical symotoms of PAR including rhinirrhea, sneezing, nasal obstruction anditching in nose and eyes for at least 2 previous consecutive years.

  • Postive skin prick test(SPT) to hose dust mite, mold, animal dander and cockcroachwith regular AR medications withould for 3 days prior to the test

Exclusion

Exclusion Criteria:

  • Pregnant women and women at risk of conception

  • Received allergen injections in previous 2 years

  • Regular medications for AR or cold and other allergic disorder

  • Seasonal allergic rhinitis, vasomotor rhinitis and rhinitis medicamentosa

  • Nasal structure deformities, nasal polyps and hypertrophic rhinitis

  • Systematic cortisosteroid used within recent 3 months or nasal cortisosteroid with 15days

  • Other active respiratory disorders

  • Active medical disorders: cancer, infection, hematology, renal, hepatic,cardiovascular, metabolic and gastrointestinal diseases

Study Design

Total Participants: 126
Study Start date:
March 01, 2004
Estimated Completion Date:
April 30, 2006

Study Description

It is a randomized, double-blind, placebo-controlled trial.

Connect with a study center

  • Department of ENT, Prince of Wales Hospital

    Hong Kong,
    Hong Kong

    Site Not Available

  • Department of ENT, Yan Chai Hospital

    Hong Kong,
    Hong Kong

    Site Not Available

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