Pharmacogenomic Study in Patients of Lung, Colorectal and Head/Neck Cancers Receiving Chemotherapy

Last updated: November 23, 2016
Sponsor: University of Kansas Medical Center
Overall Status: Completed

Phase

N/A

Condition

Nasopharyngeal Cancer

Head And Neck Cancer

Colon Cancer

Treatment

N/A

Clinical Study ID

NCT00442520
10270
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to look at several genes that might determine how the body processes the drugs used to treat lung, colorectal and head and neck cancers. The goal of this examination is to help investigators determine the proper dosage to give future cancer patients or to better predict which future patients will respond to particular drug therapies.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Lung, Colorectal and Head and Neck Cancer Patients that have received or plan toreceive chemotherapy as part of their treatment

Exclusion

Exclusion Criteria:

  • Colorectal cancer patients that have never received or will not receive chemotherapyas part of their therapy

  • Head and Neck cancer patients that have never received or will not receivechemotherapy as part of their treatment

  • Patients with cancer types other than colorectal or head and neck

  • Unable to give informed consent

Study Design

Total Participants: 70
Study Start date:
February 01, 2006
Estimated Completion Date:
September 30, 2008

Study Description

This study is to establish a pilot pharmacogenomic program in identifying genetic variation to predict the safety, toxicity and/or efficacy of drugs. DNA will be extracted from patients' peripheral blood to study SNPs in DPD, TS, MTHFR, UGT1A1, CYP3A4, CYP3A5, GSTM1, GSTT1, GSTP1, HO-1, ERCC1, XPD, XRCC1 and EGFR genes. The results of genetic study will be compared to treatment efficacy and toxicity. The ultimate goal is to use genotype profiles to provide individualized cancer treatment to improve outcome and decrease toxicity.

Connect with a study center

  • University of Kansas Medical Center

    Kansas City, Kansas 66160
    United States

    Site Not Available

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