Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

Phase

N/A

Condition

Panic Disorders

Mood Disorders

Affective Disorders

Treatment

7T Magnetic Resonance Imaging scanner

Clinical Study ID

NCT00397111

070021

07-M-0021

Ages 18-65
All Genders
Accepts Healthy Volunteers

Study Summary

This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Researchers believe that depression and anxiety disorders may cause structural and functional changes in the brain. This study will optimize the way MRI scans are collected to look at brain structure and examine how the brain behaves while subjects perform particular tasks. Healthy volunteers and individuals with major depressive disorder may be eligible for this study.

Participants undergo magnetic resonance imaging (MRI) and neuropsychological testing. : Individuals will be asked to participate in an MRI study on one of several scanners. The scanner used will measure blood flow in the brain, concentrations of certain chemicals in the brain, or magnetic properties of the brain. The scan may involve They watching a screen presenting images or doing a task in which they respond to pictures or sounds. Participants may be asked to return for additional scans.

The study also involves neuropsychological tests, which assess cognitive performance. Often, people with mood disorders have subtle changes in performance on these tests that allow researchers to pinpoint where brain abnormalities occur. Before the tests can be used in patients, they must be validated by using healthy subjects. These tests are presented either orally, in written form, or on a computer.

Eligibility Criteria

Inclusion

INCLUSION CRITERIA:

Healthy Controls

Male and female subjects between 18 and 65 years of age
Subjects must be able to give written informed consent prior to participation inthis study.
Subjects who do not currently meet and have never met criteria for any majorpsychiatric disorder, and who have no known first degree relatives with mooddisorders.
For cognitive experiments utilizing language stimuli only native English speakerswill be enrolled.

Major Depressive Disorder

Male and female subjects between 18 and 65 years of age.
Subjects have been found eligible for other ETPB research protocols according to 01-M-0254.
Subjects must fulfill DSM-IV or V criteria for Major Depression based on clinicalassessment and confirmed by a structured diagnostic interview (SCID-P).
Subjects must be able to give written informed consent prior to participation inthis study.
For cognitive experiments utilizing language stimuli, only native English speakerswill be enrolled.

Exclusion

EXCLUSION CRITERIA:

Healthy Control

Subjects with major medical or neurological disorders expected to influence cerebralblood flow or morphology, or taking any medication that is likely to influence theimaging parameters-of-interest within 3 weeks of scanning.
Women who are pregnant are excluded from the study. Subjects will undergo pregnancytesting no more than 24 hours prior to MRI scanning.
Subjects with contraindication to MRI scanning such as aneurysm clips, implantedneural stimulator, implanted cardiac pacemaker or auto-defibrillator, cochlearimplant, or ocular foreign body.
A history of drug or alcohol abuse within 1 year or a lifetime history of drug oralcohol dependence (DSM-IV) or alcohol use disorder (DSM-V equivalent).

Major Depressive Disorder

Presence of Axis 1 psychiatric diagnosis other than Major Depression or an Axis 2disorder
Subjects with major medical or neurological disorders expected to influencecognitive function or are taking any drugs likely to affect mood or cognitivefunction within 1 week of study participation. Depressed subjects will not betapered/withdrawn from medications under this study.
A history of drug or alcohol abuse within 1 year or a lifetime history of drug oralcohol dependence (DSM-IV) or alcohol use disorder (DSM-V equivalent).
Subjects with major medical or neurological disorders expected to influence cerebralblood flow or morphology.
Women who are pregnant or breastfeeding will be excluded from MRI portions of thestudy. Subjects will undergo pregnancy testing no more than 24 hours prior to MRIscanning.
Subjects with contraindication to MRI scanning such as aneurysm clips, implantedneural stimulator, implanted cardiac pacemaker or auto-defibrillator, cochlearimplant, or ocular foreign body.

Study Design

7T Magnetic Resonance Imaging scanner

December 06, 2006

Study Description

Objective

A major component of understanding the pathogenesis of mood and anxiety disorders is expected to involve elucidation of abnormalities in brain structure and function associated with these conditions. Historically post-mortem histopathological and neurochemical assessments constituted the primary methods for investigating abnormalities of brain structure and function in psychiatric disorders. However, the significance of the results from such studies has been limited by the relatively poor availability of specimens from subjects with mood and anxiety disorders who had been unmedicated and clinically well-characterized antemortem. By allowing for in vivo human studies, medical imaging technologies provide efficient, accurate, and non-invasive alternatives for characterizing brain structure and function. The recent rapid development of magnetic resonance imaging (MRI) technology, in particular, has provided powerful tools for assessing a wide range of cerebral physiological and morphological characteristics. To optimally exploit the potential of these rapidly evolving MRI scanning and hardware capabilities in investigations of mood and anxiety disorders, new techniques and applications must be developed and tested. The technical development protocol proposed herein will assess new imaging techniques and hardware, and will develop novel cognitive tasks for application in the study of mood and anxiety disorders. The primary objective of this protocol is the development of MRI experiments for characterizing the physiological correlates of mood and anxiety disorders. In addition, the pilot projects encompassed within this protocol involve the optimization of existing MRI pulse sequences, the application of new pulse sequences for structural and functional MR imaging, and the development of new functional MRI (fMRI) tasks that can elucidate neural function within the cognitive-behavioral domains affected in mood and anxiety disorders. This protocol will also allow testing of existing imaging hardware that can increase the spatial resolution, contrast, and sensitivity of MR images. Such hardware includes the use of multi-channel radio frequency (RF) coils and patient monitoring equipment. Development of these techniques and applications will directly enhance the sensitivity and specificity of MRI studies of mood and anxiety disorders.

Study Population

This study will involve 300 healthy volunteers and 90 patients with major depressive disorder.

Design

This technical development protocol will assess new imaging techniques and hardware, and will develop novel cognitive tasks for application in the study of mood and anxiety disorders. Subjects will have the option to participate in one or several procedures conducted under this protocol, including fMRI, Magnetic Resonance Spectroscopy (MRS), Magnetoencephalography (MEG), behavioral tasks, and rating scales.

Outcome Measures

Primary outcome measures on neuropsychological tests will include parameters such as accuracy and reaction time. Secondary outcome measures will include differences in reaction time or accuracy between different testing conditions. Outcome measures from MRI scanning sessions will include signal-to-noise ratio, contrast-to-noise ratio, structural volumes, metabolite concentrations (in the case of MRS), relaxation times (in the case of relaxometry), and BOLD time series (in the case of fMRI).

Connect with a study center

National Institutes of Health Clinical Center
Bethesda, Maryland 20892
United States
Active - Recruiting
National Institutes of Health Clinical Center
Bethesda 4348599, Maryland 4361885 20892
United States
Site Not Available

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