S0500 Treatment Decision Making Based on Blood Levels of Tumor Cells for Metastatic Breast Cancer Treated With Chemo

Last updated: October 3, 2017
Sponsor: Southwest Oncology Group
Overall Status: Completed

Phase

3

Condition

Breast Cancer

Cancer

Treatment

chemotherapy

Clinical Study ID

NCT00382018
CDR0000504319
S0500
U10CA032102
  • Ages > 18
  • Female

Study Summary

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Measuring blood levels of tumor cells may help in learning how well chemotherapy works to kill metastatic breast cancer cells and allow doctors to plan better treatment. When blood levels of tumor cells are high while receiving chemotherapy, it is not yet known whether it is more effective to change chemotherapy regimens at that time or wait until disease progression.

PURPOSE: This randomized phase III trial is studying treatment decision making based on blood levels of tumor cells in women with metastatic breast cancer receiving chemotherapy.

Eligibility Criteria

Inclusion

DISEASE CHARACTERISTICS:

  • Histologically confirmed breast cancer

  • Clinical evidence of metastatic disease (stage IV disease)

  • Newly metastatic disease OR progressive metastatic disease while on hormonal therapy

  • Meets 1 of the following criteria:

  • Measurable disease

  • Bone-only disease* NOTE: *Patients with nonmeasurable disease that does not include bone are not eligible

  • HER-2 status determined by immunohistochemistry (IHC) or fluorescent in situ hybridization (FISH) assay

  • HER-2 positivity is defined as IHC 3+ or FISH+

  • If IHC is indeterminate (2+), FISH must be performed to classify disease

  • Planning to undergo first-line chemotherapy for metastatic disease

  • Patients with brain metastases must have stable disease for > 90 days after completion of prior radiotherapy to the brain

  • No leptomeningeal disease

  • Hormone receptor status not specified

PATIENT CHARACTERISTICS:

  • Female

  • Menopausal status not specified

  • Zubrod performance status 0-2

  • Not pregnant or nursing

  • Negative pregnancy test

  • No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or stage I or II cancer currently in complete remission

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics

  • Prior hormonal therapy, bisphosphonate therapy, trastuzumab (Herceptin®), and/or bevacizumab for metastatic disease allowed

  • Any number of exogenous hormonal therapies for metastatic disease and/or as adjuvant therapy allowed

  • At least 1 year since prior adjuvant chemotherapy

  • At least 2 weeks since prior minor surgery and recovered

  • At least 4 weeks since prior major surgery and recovered

  • No prior chemotherapy for metastatic disease

  • Concurrent hormonal therapy and/or bisphosphonate therapy allowed

  • Concurrent trastuzumab and/or bevacizumab allowed

Study Design

Total Participants: 624
Treatment Group(s): 1
Primary Treatment: chemotherapy
Phase: 3
Study Start date:
October 01, 2006
Estimated Completion Date:
July 11, 2017

Study Description

OBJECTIVES:

Primary

  • Determine whether women with metastatic breast cancer and elevated circulating tumor cells (CTCs) (≥ 5 per 7.5 mL of whole blood) after 3 weeks of first-line chemotherapy derive increased overall survival from changing to an alternative chemotherapy regimen at the next course rather than waiting for clinical evidence of progressive disease before changing to an alternative chemotherapy regimen.

  • Determine whether these patients derive increased progression-free survival (PFS) from changing to an alternative chemotherapy regimen at the next course rather than waiting for clinical evidence of progressive disease before changing to an alternative chemotherapy regimen.

  • Confirm previous findings that patients with < 5 CTCs per 7.5 mL of whole blood on initial screening have longer median OS and PFS than patients with ≥ 5 CTCs per 7.5 mL of whole blood.

  • Determine the prognostic value of sequentially collected CTC values in these patients.

  • Compare toxicity between patients with and without elevated CTCs after 3 weeks of first-line chemotherapy AND between the two randomized treatment arms.

Secondary

  • Compare the prognostic and predictive value of CTC number vs breast cancer tumor markers, including CA 15-3 and carcinoembryonic antigen.

  • Create a serum specimen bank for future biologic investigation.

OUTLINE: This is a partially blinded, partially randomized, multicenter study. Patients are assigned to 1 of 3 groups based on circulating tumor cells (CTCs) after 1 course of chemotherapy.

All patients undergo blood collection before their first dose of first-line chemotherapy* to determine baseline CTC count. Patients with < 5 CTCs at baseline are assigned to group I. Patients with ≥ 5 CTCs at baseline undergo a second blood draw on day 22 (after completion of 1 course of chemotherapy). Patients with < 5 CTCs after completing 1 course of chemotherapy are assigned to group 2. Patients with ≥ 5 CTCs after completion of 1 course of chemotherapy are assigned to group 3.

NOTE: *Chemotherapy may be initiated while waiting for the baseline CTC result.

  • Group 1 (low risk of early progression): Patients continue to receive regular treatment without change at the discretion of the physician. Patients are eligible for other first-line chemotherapy trials. No further blood is collected.

  • Group 2 (moderate risk of early progression): Patients continue to receive their current chemotherapy regimen without change.

  • Group 3 (high risk of early progression): Patients are stratified according to HER-2 status (positive vs negative) and disease type (bone-only vs measurable disease). Patients are randomized to 1 of 2 treatment arms.

    • Arm I: Patients continue with their current chemotherapy regimen without change.

    • Arm II: Patients switch to a different chemotherapy regimen. Selection of a new chemotherapy regimen is made by the patient's doctor.

Patients receiving hormonal therapy or biologic therapy and chemotherapy continue to receive the hormonal or biologic therapy unchanged regardless of CTC level.

In groups 2 and 3, blood is collected periodically during chemotherapy and then at the completion of chemotherapy. Samples are examined for CTCs via the CellSearch™ blood test. Blood is also tested for CA 15-3 and carcinoembryonic antigen (CEA).

After completion of study therapy, patients are followed for up to 5 years.

PROJECTED ACCRUAL: A total of 500 patients will be accrued for this study.

Connect with a study center

  • Regional Medical Center

    Anniston, Alabama 36207
    United States

    Site Not Available

  • Alaska Regional Hospital Cancer Center

    Anchorage, Alaska 99508
    United States

    Site Not Available

  • Providence Cancer Center

    Anchorage, Alaska 99508
    United States

    Site Not Available

  • NEA Medical Center - Stadium Boulevard

    Jonesboro, Arkansas 72401
    United States

    Site Not Available

  • Glendale Memorial Hospital Comprehensive Cancer Center

    Glendale, California 91204
    United States

    Site Not Available

  • California Cancer Care, Incorporated - Greenbrae

    Greenbrae, California 94904
    United States

    Site Not Available

  • Loma Linda University Cancer Institute at Loma Linda University Medical Center

    Loma Linda, California 92354
    United States

    Site Not Available

  • USC/Norris Comprehensive Cancer Center and Hospital

    Los Angeles, California 90089-9181
    United States

    Site Not Available

  • Camino Medical Group - Treatment Center

    Mountain View, California 94040
    United States

    Site Not Available

  • Palo Alto Medical Foundation

    Palo Alto, California 94301
    United States

    Site Not Available

  • Salinas Valley Memorial Hospital

    Salinas, California 93901
    United States

    Site Not Available

  • Stanford Cancer Center

    Stanford, California 94305-5824
    United States

    Site Not Available

  • San Luis Valley Regional Medical Center

    Alamosa, Colorado 81101
    United States

    Site Not Available

  • University of Colorado Cancer Center at UC Health Sciences Center

    Aurora, Colorado 80045
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Denver

    Denver, Colorado 80220
    United States

    Site Not Available

  • Shaw Regional Cancer Center

    Edwards, Colorado 81632
    United States

    Site Not Available

  • Valley View Hospital Cancer Center

    Glenwood Springs, Colorado 81601
    United States

    Site Not Available

  • St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center

    Grand Junction, Colorado 81502
    United States

    Site Not Available

  • Montrose Memorial Hospital Cancer Center

    Montrose, Colorado 81401
    United States

    Site Not Available

  • Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

    Hartford, Connecticut 06105
    United States

    Site Not Available

  • Yale Cancer Center

    New Haven, Connecticut 06520-8028
    United States

    Site Not Available

  • Florida Hospital Cancer Institute at Florida Hospital Orlando

    Orlando, Florida 32803-1273
    United States

    Site Not Available

  • Pearlman Comprehensive Cancer Center at South Georgia Medical Center

    Valdosta, Georgia 31602
    United States

    Site Not Available

  • Kapiolani Medical Center at Pali Momi

    'Aiea, Hawaii 96701
    United States

    Site Not Available

  • Kapiolani Medical Center at Pali Momi

    Aiea, Hawaii 96701
    United States

    Site Not Available

  • Cancer Research Center of Hawaii

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Hawaii Medical Center - East

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii 96826
    United States

    Site Not Available

  • OnCare Hawaii, Incorporated - Kuakini

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • OnCare Hawaii, Incorporated - Lusitana

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Queen's Cancer Institute at Queen's Medical Center

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Straub Clinic and Hospital, Incorporated

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Tripler Army Medical Center

    Honolulu, Hawaii 96859
    United States

    Site Not Available

  • Maui Memorial Medical Center

    Wailuku, Hawaii 96793
    United States

    Site Not Available

  • Pacific Cancer Institute - Maui

    Wailuku, Hawaii 96793
    United States

    Site Not Available

  • Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

    Boise, Idaho 83706
    United States

    Site Not Available

  • Rush-Copley Cancer Care Center

    Aurora, Illinois 60504
    United States

    Site Not Available

  • Louis A. Weiss Memorial Hospital

    Chicago, Illinois 60640
    United States

    Site Not Available

  • Resurrection Medical Center

    Chicago, Illinois 60631
    United States

    Site Not Available

  • Elmhurst Memorial Hospital

    Elmhurst, Illinois 60126
    United States

    Site Not Available

  • Ingalls Cancer Care Center at Ingalls Memorial Hospital

    Harvey, Illinois 60426
    United States

    Site Not Available

  • Swedish-American Regional Cancer Center

    Rockford, Illinois 61104-2315
    United States

    Site Not Available

  • CCOP - Carle Cancer Center

    Urbana, Illinois 61801
    United States

    Site Not Available

  • Elkhart Clinic, LLC

    Elkhart, Indiana 46514-2098
    United States

    Site Not Available

  • Elkhart General Hospital

    Elkhart, Indiana 46515
    United States

    Site Not Available

  • Michiana Hematology-Oncology, PC - Elkhart

    Elkhart, Indiana 46514
    United States

    Site Not Available

  • Fort Wayne Medical Oncology and Hematology

    Fort Wayne, Indiana 46845
    United States

    Site Not Available

  • Community Regional Cancer Care at Community Hospital North

    Indianapolis, Indiana 46256
    United States

    Site Not Available

  • St. Vincent Indianapolis Hospital

    Indianapolis, Indiana 46260
    United States

    Site Not Available

  • Howard Community Hospital

    Kokomo, Indiana 46904
    United States

    Site Not Available

  • Center for Cancer Therapy at LaPorte Hospital and Health Services

    La Porte, Indiana 46350
    United States

    Site Not Available

  • Saint Anthony Memorial Health Centers

    Michigan City, Indiana 46360
    United States

    Site Not Available

  • Michiana Hematology-Oncology, PC - South Bend

    Mishawaka, Indiana 46545-1470
    United States

    Site Not Available

  • Saint Joseph Regional Medical Center

    Mishawaka, Indiana 46545-1470
    United States

    Site Not Available

  • Cancer Center at Ball Memorial Hospital

    Muncie, Indiana 47303-3499
    United States

    Site Not Available

  • Michiana Hematology Oncology PC - Plymouth

    Plymouth, Indiana 46563
    United States

    Site Not Available

  • CCOP - Northern Indiana CR Consortium

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Memorial Hospital of South Bend

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Michiana Hematology Oncology PC - La Porte

    Westville, Indiana 46391
    United States

    Site Not Available

  • McFarland Clinic, PC

    Ames, Iowa 50010
    United States

    Site Not Available

  • Mercy Medical Center - Sioux City

    Sioux City, Iowa 51102
    United States

    Site Not Available

  • Siouxland Hematology-Oncology Associates, LLP

    Sioux City, Iowa 51101
    United States

    Site Not Available

  • St. Luke's Regional Medical Center

    Sioux City, Iowa 51104
    United States

    Site Not Available

  • Covenant Cancer Treatment Center

    Waterloo, Iowa 50702
    United States

    Site Not Available

  • Tammy Walker Cancer Center at Salina Regional Health Center

    Salina, Kansas 67401
    United States

    Site Not Available

  • Cotton-O'Neil Cancer Center

    Topeka, Kansas 66606
    United States

    Site Not Available

  • Mercy Hospital

    Portland, Maine 04101
    United States

    Site Not Available

  • Alvin and Lois Lapidus Cancer Institute at Sinai Hospital

    Baltimore, Maryland 21215
    United States

    Site Not Available

  • Saint Vincent Hospital at Worcester Medical Center

    Worcester, Massachusetts 01608
    United States

    Site Not Available

  • Hickman Cancer Center at Bixby Medical Center

    Adrian, Michigan 49221
    United States

    Site Not Available

  • CCOP - Michigan Cancer Research Consortium

    Ann Arbor, Michigan 48106
    United States

    Site Not Available

  • Saint Joseph Mercy Cancer Center

    Ann Arbor, Michigan 48106-0995
    United States

    Site Not Available

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan 48109-0942
    United States

    Site Not Available

  • Battle Creek Health System Cancer Care Center

    Battle Creek, Michigan 49017
    United States

    Site Not Available

  • Bay Regional Medical Center

    Bay City, Michigan 48708
    United States

    Site Not Available

  • Mecosta County Medical Center

    Big Rapids, Michigan 49307
    United States

    Site Not Available

  • Oakwood Cancer Center at Oakwood Hospital and Medical Center

    Dearborn, Michigan 48123-2500
    United States

    Site Not Available

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan 48201-1379
    United States

    Site Not Available

  • Josephine Ford Cancer Center at Henry Ford Hospital

    Detroit, Michigan 48202
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Escanaba

    Escanaba, Michigan 49431
    United States

    Site Not Available

  • Genesys Hurley Cancer Institute

    Flint, Michigan 48503
    United States

    Site Not Available

  • Hurley Medical Center

    Flint, Michigan 48503
    United States

    Site Not Available

  • Butterworth Hospital at Spectrum Health

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • CCOP - Grand Rapids

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Lacks Cancer Center at Saint Mary's Health Care

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Van Elslander Cancer Center at St. John Hospital and Medical Center

    Grosse Pointe Woods, Michigan 48236
    United States

    Site Not Available

  • Dickinson County Healthcare System

    Iron Mountain, Michigan 49801
    United States

    Site Not Available

  • Foote Memorial Hospital

    Jackson, Michigan 49201
    United States

    Site Not Available

  • Borgess Medical Center

    Kalamazoo, Michigan 49001
    United States

    Site Not Available

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007-3731
    United States

    Site Not Available

  • Breslin Cancer Center at Ingham Regional Medical Center

    Lansing, Michigan 48910
    United States

    Site Not Available

  • Sparrow Regional Cancer Center

    Lansing, Michigan 48912-1811
    United States

    Site Not Available

  • St. Mary Mercy Hospital

    Livonia, Michigan 48154
    United States

    Site Not Available

  • Community Cancer Center of Monroe

    Monroe, Michigan 48162
    United States

    Site Not Available

  • Mercy Memorial Hospital - Monroe

    Monroe, Michigan 48162
    United States

    Site Not Available

  • Clemens Regional Medical Center

    Mount Clemens, Michigan 48043
    United States

    Site Not Available

  • Mercy General Health Partners

    Muskegon, Michigan 49443
    United States

    Site Not Available

  • Michiana Hematology Oncology PC - Niles

    Niles, Michigan 49120
    United States

    Site Not Available

  • St. Joseph Mercy Oakland

    Pontiac, Michigan 48341-2985
    United States

    Site Not Available

  • Mercy Regional Cancer Center at Mercy Hospital

    Port Huron, Michigan 48060
    United States

    Site Not Available

  • Spectrum Health Reed City Hospital

    Reed City, Michigan 49677
    United States

    Site Not Available

  • William Beaumont Hospital - Royal Oak Campus

    Royal Oak, Michigan 48073
    United States

    Site Not Available

  • Seton Cancer Institute at Saint Mary's - Saginaw

    Saginaw, Michigan 48601
    United States

    Site Not Available

  • Lakeland Regional Cancer Care Center - St. Joseph

    Saint Joseph, Michigan 49085
    United States

    Site Not Available

  • Lakeside Cancer Specialists, PLLC

    Saint Joseph, Michigan 49085
    United States

    Site Not Available

  • Providence Cancer Institute at Providence Hospital - Southfield Campus

    Southfield, Michigan 48075
    United States

    Site Not Available

  • Lakeland Regional Cancer Care Center - St. Joseph

    St. Joseph, Michigan 49085
    United States

    Site Not Available

  • Munson Medical Center

    Traverse City, Michigan 49684
    United States

    Site Not Available

  • St. John Macomb Hospital

    Warren, Michigan 48093
    United States

    Site Not Available

  • Alexandria, Minnesota 56308
    United States

    Site Not Available

  • Fairview Ridges Hospital

    Burnsville, Minnesota 55337
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Mercy Hospital

    Coon Rapids, Minnesota 55433
    United States

    Site Not Available

  • Fairview Southdale Hospital

    Edina, Minnesota 55435
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Unity Hospital

    Fridley, Minnesota 55432
    United States

    Site Not Available

  • Hutchinson Area Health Care

    Hutchinson, Minnesota 55350
    United States

    Site Not Available

  • HealthEast Cancer Care at St. John's Hospital

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Minnesota Oncology Hematology, PA - Maplewood

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Hennepin County Medical Center - Minneapolis

    Minneapolis, Minnesota 55415
    United States

    Site Not Available

  • Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

    Minneapolis, Minnesota 55407
    United States

    Site Not Available

  • Humphrey Cancer Center at North Memorial Outpatient Center

    Robbinsdale, Minnesota 55422-2900
    United States

    Site Not Available

  • CentraCare Clinic - River Campus

    Saint Cloud, Minnesota 56303
    United States

    Site Not Available

  • Coborn Cancer Center

    Saint Cloud, Minnesota 56303
    United States

    Site Not Available

  • CCOP - Metro-Minnesota

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Park Nicollet Cancer Center

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Regions Hospital Cancer Care Center

    Saint Paul, Minnesota 55101
    United States

    Site Not Available

  • United Hospital

    Saint Paul, Minnesota 55102
    United States

    Site Not Available

  • St. Francis Cancer Center at St. Francis Medical Center

    Shakopee, Minnesota 55379
    United States

    Site Not Available

  • Regions Hospital Cancer Care Center

    St. Paul, Minnesota 55101
    United States

    Site Not Available

  • Lakeview Hospital

    Stillwater, Minnesota 55082
    United States

    Site Not Available

  • Ridgeview Medical Center

    Waconia, Minnesota 55387
    United States

    Site Not Available

  • Willmar Cancer Center at Rice Memorial Hospital

    Willmar, Minnesota 56201
    United States

    Site Not Available

  • Minnesota Oncology Hematology, PA - Woodbury

    Woodbury, Minnesota 55125
    United States

    Site Not Available

  • University of Mississippi Cancer Clinic

    Jackson, Mississippi 39216
    United States

    Site Not Available

  • Regional Cancer Center at Singing River Hospital

    Pascagoula, Mississippi 39581
    United States

    Site Not Available

  • Central Care Cancer Center at Carrie J. Babb Cancer Center

    Bolivar, Missouri 65613
    United States

    Site Not Available

  • Southeast Cancer Center

    Cape Girardeau, Missouri 63703
    United States

    Site Not Available

  • Goldschmidt Cancer Center

    Jefferson City, Missouri 65109
    United States

    Site Not Available

  • Comprehensive Cancer Care, PC

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Missouri Baptist Cancer Center

    Saint Louis, Missouri 63131
    United States

    Site Not Available

  • CCOP - Cancer Research for the Ozarks

    Springfield, Missouri 65802
    United States

    Site Not Available

  • Hulston Cancer Center at Cox Medical Center South

    Springfield, Missouri 65807
    United States

    Site Not Available

  • St. John's Regional Health Center

    Springfield, Missouri 65804
    United States

    Site Not Available

  • Billings Clinic - Downtown

    Billings, Montana 59107-7000
    United States

    Site Not Available

  • CCOP - Montana Cancer Consortium

    Billings, Montana 59101
    United States

    Site Not Available

  • Hematology-Oncology Centers of the Northern Rockies - Billings

    Billings, Montana 59102
    United States

    Site Not Available

  • St. Vincent Healthcare Cancer Care Services

    Billings, Montana 59101
    United States

    Site Not Available

  • Bozeman Deaconess Cancer Center

    Bozeman, Montana 59715
    United States

    Site Not Available

  • St. James Healthcare Cancer Care

    Butte, Montana 59701
    United States

    Site Not Available

  • Big Sky Oncology

    Great Falls, Montana 59405-5309
    United States

    Site Not Available

  • Great Falls Clinic - Main Facility

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Sletten Cancer Institute at Benefis Healthcare

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Northern Montana Hospital

    Havre, Montana 59501
    United States

    Site Not Available

  • St. Peter's Hospital

    Helena, Montana 59601
    United States

    Site Not Available

  • Glacier Oncology, PLLC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Medical Oncology at KRMC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Regional Medical Center

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

    Missoula, Montana 59807
    United States

    Site Not Available

  • Montana Cancer Specialists at Montana Cancer Center

    Missoula, Montana 59807-7877
    United States

    Site Not Available

  • Good Samaritan Cancer Center at Good Samaritan Hospital

    Kearney, Nebraska 68848-1990
    United States

    Site Not Available

  • Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire 03756-0002
    United States

    Site Not Available

  • Carol G. Simon Cancer Center at Morristown Memorial Hospital

    Morristown, New Jersey 07962
    United States

    Site Not Available

  • Saint Peter's University Hospital

    New Brunswick, New Jersey 08901
    United States

    Site Not Available

  • Newark Beth Israel Medical Center

    Newark, New Jersey 07112
    United States

    Site Not Available

  • UMDNJ University Hospital

    Newark, New Jersey 07103
    United States

    Site Not Available

  • St. Joseph's Hospital and Medical Center

    Paterson, New Jersey 07503
    United States

    Site Not Available

  • Overlook Hospital

    Summit, New Jersey 07902
    United States

    Site Not Available

  • Hematology Oncology Associates, PC

    Albuquerque, New Mexico 87106
    United States

    Site Not Available

  • Lovelace Medical Center - Downtown

    Albuquerque, New Mexico 87102
    United States

    Site Not Available

  • Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital

    Albuquerque, New Mexico 87110
    United States

    Site Not Available

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico 87131-5636
    United States

    Site Not Available

  • University of New Mexico Cancer Center - South

    Las Cruces, New Mexico 88011
    United States

    Site Not Available

  • Albert Einstein Cancer Center at Albert Einstein College of Medicine

    Bronx, New York 10461
    United States

    Site Not Available

  • Roswell Park Cancer Institute

    Buffalo, New York 14263-0001
    United States

    Site Not Available

  • CCOP - Hematology-Oncology Associates of Central New York

    East Syracuse, New York 13057
    United States

    Site Not Available

  • Albert Einstein Cancer Center at Albert Einstein College of Medicine

    The Bronx, New York 10461
    United States

    Site Not Available

  • Faxton Regional Cancer Center

    Utica, New York 13502
    United States

    Site Not Available

  • Dickstein Cancer Treatment Center at White Plains Hospital Center

    White Plains, New York 10601
    United States

    Site Not Available

  • Mission Hospitals - Memorial Campus

    Asheville, North Carolina 28801
    United States

    Site Not Available

  • Duke Cancer Institute

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Wayne Memorial Hospital, Incorporated

    Goldsboro, North Carolina 27534
    United States

    Site Not Available

  • Pardee Memorial Hospital

    Hendersonville, North Carolina 28791
    United States

    Site Not Available

  • Kinston Medical Specialists

    Kinston, North Carolina 28501
    United States

    Site Not Available

  • Southeastern Regional Medical Center

    Lumberton, North Carolina 28359
    United States

    Site Not Available

  • Granville Medical Center

    Oxford, North Carolina 27565
    United States

    Site Not Available

  • Duke Health Raleigh Hospital

    Raleigh, North Carolina 27609
    United States

    Site Not Available

  • Person Memorial Hospital

    Roxboro, North Carolina 27573
    United States

    Site Not Available

  • Bismarck Cancer Center

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • Medcenter One Hospital Cancer Care Center

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • Mid Dakota Clinic, PC

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • St. Alexius Medical Center Cancer Center

    Bismarck, North Dakota 58502
    United States

    Site Not Available

  • Altru Cancer Center at Altru Hospital

    Grand Forks, North Dakota 58201
    United States

    Site Not Available

  • Trinity CancerCare Center

    Minot, North Dakota 58701
    United States

    Site Not Available

  • Cleveland Clinic Beachwood Family Health and Surgery Center

    Beachwood, Ohio 44122
    United States

    Site Not Available

  • Wood County Oncology Center

    Bowling Green, Ohio 43402
    United States

    Site Not Available

  • Charles M. Barrett Cancer Center at University Hospital

    Cincinnati, Ohio 45267
    United States

    Site Not Available

  • Cleveland Clinic Cancer Center at Fairview Hospital

    Cleveland, Ohio 44111
    United States

    Site Not Available

  • Cleveland Clinic Taussig Cancer Center

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • North Coast Cancer Care - Clyde

    Clyde, Ohio 43410
    United States

    Site Not Available

  • Community Cancer Center

    Elyria, Ohio 44035
    United States

    Site Not Available

  • Hematology Oncology Center

    Elyria, Ohio 44035
    United States

    Site Not Available

  • Cleveland Clinic Cancer Center

    Independence, Ohio 44131
    United States

    Site Not Available

  • Lima Memorial Hospital

    Lima, Ohio 45804
    United States

    Site Not Available

  • St. Rita's Medical Center

    Lima, Ohio 45801
    United States

    Site Not Available

  • Northwest Ohio Oncology Center

    Maumee, Ohio 43537-1839
    United States

    Site Not Available

  • Hillcrest Cancer Center at Hillcrest Hospital

    Mayfield Heights, Ohio 44124
    United States

    Site Not Available

  • Lake/University Ireland Cancer Center

    Mentor, Ohio 44060
    United States

    Site Not Available

  • Fisher-Titus Medical Center

    Norwalk, Ohio 44857
    United States

    Site Not Available

  • UHHS Chagrin Highlands Medical Center

    Orange Village, Ohio 44122
    United States

    Site Not Available

  • St. Charles Mercy Hospital

    Oregon, Ohio 43616
    United States

    Site Not Available

  • Toledo Clinic - Oregon

    Oregon, Ohio 43616
    United States

    Site Not Available

  • Parma Community General Hospital

    Parma, Ohio 44129
    United States

    Site Not Available

  • North Coast Cancer Care, Incorporated

    Sandusky, Ohio 44870
    United States

    Site Not Available

  • Cleveland Clinic Foundation - Strongsville

    Strongsville, Ohio 44136
    United States

    Site Not Available

  • Flower Hospital Cancer Center

    Sylvania, Ohio 43560
    United States

    Site Not Available

  • Mercy Hospital of Tiffin

    Tiffin, Ohio 44883
    United States

    Site Not Available

  • CCOP - Toledo Community Hospital

    Toledo, Ohio 43617
    United States

    Site Not Available

  • Medical University of Ohio Cancer Center

    Toledo, Ohio 43614
    United States

    Site Not Available

  • St. Anne Mercy Hospital

    Toledo, Ohio 43623
    United States

    Site Not Available

  • St. Vincent Mercy Medical Center

    Toledo, Ohio 43608
    United States

    Site Not Available

  • Toledo Clinic, Incorporated - Main Clinic

    Toledo, Ohio 43623
    United States

    Site Not Available

  • Toledo Hospital

    Toledo, Ohio 43606
    United States

    Site Not Available

  • Fulton County Health Center

    Wauseon, Ohio 43567
    United States

    Site Not Available

  • UHHS Westlake Medical Center

    Westlake, Ohio 44145
    United States

    Site Not Available

  • Cleveland Clinic - Wooster

    Wooster, Ohio 44691
    United States

    Site Not Available

  • Natalie Warren Bryant Cancer Center at St. Francis Hospital

    Tulsa, Oklahoma 74136
    United States

    Site Not Available

  • St. Charles Medical Center - Bend

    Bend, Oregon 97701
    United States

    Site Not Available

  • Clackamas Radiation Oncology Center

    Clackamas, Oregon 97015
    United States

    Site Not Available

  • Bay Area Hospital

    Coos Bay, Oregon 97420
    United States

    Site Not Available

  • Three Rivers Community Hospital

    Grants Pass, Oregon 97527
    United States

    Site Not Available

  • Dubs Cancer Center at Rogue Valley Medical Center

    Medford, Oregon 97504
    United States

    Site Not Available

  • Providence Cancer Center at PMCC

    Medford, Oregon 97504
    United States

    Site Not Available

  • Providence Milwaukie Hospital

    Milwaukie, Oregon 97222
    United States

    Site Not Available

  • Providence Newberg Medical Center

    Newberg, Oregon 97132
    United States

    Site Not Available

  • Willamette Falls Hospital

    Oregon City, Oregon 97045
    United States

    Site Not Available

  • CCOP - Columbia River Oncology Program

    Portland, Oregon 97225
    United States

    Site Not Available

  • Providence Cancer Center at Providence Portland Medical Center

    Portland, Oregon 97213-2967
    United States

    Site Not Available

  • Providence St. Vincent Medical Center

    Portland, Oregon 97225
    United States

    Site Not Available

  • Butler Memorial Hospital

    Butler, Pennsylvania 16001
    United States

    Site Not Available

  • Ephrata Cancer Center at Ephrata Community Hospital

    Ephrata, Pennsylvania 17522
    United States

    Site Not Available

  • Fox Chase Cancer Center - Philadelphia

    Philadelphia, Pennsylvania 19111-2497
    United States

    Site Not Available

  • Cancer Center at Phoenixville Hospital

    Phoenixville, Pennsylvania 19460
    United States

    Site Not Available

  • UPMC Cancer Centers

    Pittsburgh, Pennsylvania 15232
    United States

    Site Not Available

  • McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

    Reading, Pennsylvania 19612-6052
    United States

    Site Not Available

  • Guthrie Cancer Center at Guthrie Clinic Sayre

    Sayre, Pennsylvania 18840
    United States

    Site Not Available

  • Hematology and Oncology Associates of Northeastern Pennsylvania

    Scranton, Pennsylvania 18508
    United States

    Site Not Available

  • Roper St. Francis Cancer Center at Roper Hospital

    Charleston, South Carolina 29401
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Easley

    Easley, South Carolina 29640
    United States

    Site Not Available

  • CCOP - Greenville

    Greenville, South Carolina 29615
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Faris Road

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Grove Commons

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Greenville Hospital Cancer Center

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Self Regional Cancer Center at Self Regional Medical Center

    Greenwood, South Carolina 29646
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Greer Medical Oncology

    Greer, South Carolina 29650
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Seneca

    Seneca, South Carolina 29672
    United States

    Site Not Available

  • Cancer Centers of the Carolinas - Spartanburg

    Spartanburg, South Carolina 29307
    United States

    Site Not Available

  • West Tennessee Cancer Center at Jackson-Madison County General Hospital

    Jackson, Tennessee 38301
    United States

    Site Not Available

  • M. D. Anderson Cancer Center at University of Texas

    Houston, Texas 77030-4009
    United States

    Site Not Available

  • Cancer Therapy and Research Center

    San Antonio, Texas 78229
    United States

    Site Not Available

  • University Hospital - San Antonio

    San Antonio, Texas 78229
    United States

    Site Not Available

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas 78229-3900
    United States

    Site Not Available

  • Veterans Affairs Medical Center - San Antonio (Murphy)

    San Antonio, Texas 78209
    United States

    Site Not Available

  • CCOP - Scott and White Hospital

    Temple, Texas 76508
    United States

    Site Not Available

  • American Fork Hospital

    American Fork, Utah 84003
    United States

    Site Not Available

  • Sandra L. Maxwell Cancer Center

    Cedar City, Utah 84720
    United States

    Site Not Available

  • Logan Regional Hospital

    Logan, Utah 84321
    United States

    Site Not Available

  • Jon and Karen Huntsman Cancer Center at Intermountain Medical Center

    Murray, Utah 84157
    United States

    Site Not Available

  • Val and Ann Browning Cancer Center at McKay-Dee Hospital Center

    Ogden, Utah 84403
    United States

    Site Not Available

  • Utah Valley Regional Medical Center - Provo

    Provo, Utah 84604
    United States

    Site Not Available

  • Dixie Regional Medical Center - East Campus

    Saint George, Utah 84770
    United States

    Site Not Available

  • LDS Hospital

    Salt Lake City, Utah 84143
    United States

    Site Not Available

  • Utah Cancer Specialists at UCS Cancer Center

    Salt Lake City, Utah 84106
    United States

    Site Not Available

  • Danville Regional Medical Center

    Danville, Virginia 24541
    United States

    Site Not Available

  • Fredericksburg Oncology, Incorporated

    Fredericksburg, Virginia 22401
    United States

    Site Not Available

  • Virginia Cancer Institute - West End

    Richmond, Virginia 23230
    United States

    Site Not Available

  • Island Hospital Cancer Care Center at Island Hospital

    Anacortes, Washington 98221
    United States

    Site Not Available

  • St. Joseph Cancer Center

    Bellingham, Washington 98225
    United States

    Site Not Available

  • Olympic Hematology and Oncology

    Bremerton, Washington 98310
    United States

    Site Not Available

  • Highline Medical Center Cancer Center

    Burien, Washington 98166
    United States

    Site Not Available

  • Providence Centralia Hospital

    Centralia, Washington 98531-9027
    United States

    Site Not Available

  • St. Francis Hospital

    Federal Way, Washington 98003
    United States

    Site Not Available

  • Columbia Basin Hematology

    Kennewick, Washington 99336
    United States

    Site Not Available

  • Skagit Valley Hospital Cancer Care Center

    Mount Vernon, Washington 98274
    United States

    Site Not Available

  • Skagit Valley Hospital Cancer Care Center

    Mt. Vernon, Washington 98273
    United States

    Site Not Available

  • Providence St. Peter Hospital Regional Cancer Center

    Olympia, Washington 98506-5166
    United States

    Site Not Available

  • Harrison Poulsbo Hematology and Onocology

    Poulsbo, Washington 98370
    United States

    Site Not Available

  • Good Samaritan Cancer Center

    Puyallup, Washington 98372
    United States

    Site Not Available

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington 98109
    United States

    Site Not Available

  • Group Health Central Hospital

    Seattle, Washington 98112
    United States

    Site Not Available

  • Harborview Medical Center

    Seattle, Washington 98104
    United States

    Site Not Available

  • Minor and James Medical, PLLC

    Seattle, Washington 98104
    United States

    Site Not Available

  • Swedish Cancer Institute at Swedish Medical Center - First Hill Campus

    Seattle, Washington 98122-4307
    United States

    Site Not Available

  • University Cancer Center at University of Washington Medical Center

    Seattle, Washington 98195
    United States

    Site Not Available

  • North Puget Oncology at United General Hospital

    Sedro-Woolley, Washington 98284
    United States

    Site Not Available

  • Cancer Care Northwest - Spokane South

    Spokane, Washington 99202
    United States

    Site Not Available

  • Evergreen Hematology and Oncology, PS

    Spokane, Washington 99218
    United States

    Site Not Available

  • Allenmore Hospital

    Tacoma, Washington 98405
    United States

    Site Not Available

  • CCOP - Northwest

    Tacoma, Washington 98405
    United States

    Site Not Available

  • Franciscan Cancer Center at St. Joseph Medical Center

    Tacoma, Washington 98405-3004
    United States

    Site Not Available

  • MultiCare Regional Cancer Center at Tacoma General Hospital

    Tacoma, Washington 98405
    United States

    Site Not Available

  • St. Clare Hospital

    Tacoma, Washington 98499
    United States

    Site Not Available

  • Southwest Washington Medical Center Cancer Center

    Vancouver, Washington 98664
    United States

    Site Not Available

  • Wenatchee Valley Medical Center

    Wenatchee, Washington 98801-2028
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Mary's Hospital

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54301-3526
    United States

    Site Not Available

  • St. Mary's Hospital Medical Center - Green Bay

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54307-3508
    United States

    Site Not Available

  • Gundersen Lutheran Center for Cancer and Blood

    La Crosse, Wisconsin 54601
    United States

    Site Not Available

  • Holy Family Memorial Medical Center Cancer Care Center

    Manitowoc, Wisconsin 54221-1450
    United States

    Site Not Available

  • Bay Area Cancer Care Center at Bay Area Medical Center

    Marinette, Wisconsin 54143
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Oconto Falls

    Oconto Falls, Wisconsin 54154
    United States

    Site Not Available

  • St. Nicholas Hospital

    Sheboygan, Wisconsin 53081
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Sturgeon Bay

    Sturgeon Bay, Wisconsin 54235
    United States

    Site Not Available

  • Oncology Alliance, SC - Milwaukee - West

    Wauwatosa, Wisconsin 53226
    United States

    Site Not Available

  • Welch Cancer Center at Sheridan Memorial Hospital

    Sheridan, Wyoming 82801
    United States

    Site Not Available

+−

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.