Each year chronic kidney disease (CKD) claims the lives of millions of people worldwide.
Costs for patient care are in excess of 2.4 billion dollars in the US alone. At the
moment most kidney diseases are of unknown etiology, are classified according to a
microscopic description of the kidney tissue obtained on biopsy and are treated with
non-specific therapies.
Each kidney contains millions of filter units called nephrons. The nephron consists of a
glomerulus and a tubule. The glomerulus filters the blood of waste products, while
retaining larger molecules that are required for the body to function properly. The
filtered fluid then passes through the tubule, where salts, acids and water are regulated
to keep the body in a normal metabolic state. After the filtered fluid passes through the
tubule it is collected in the bladder as urine. Diseases, which affect the glomeruli or
tubules result in kidney damage. Once kidney function is lost it is generally not
recoverable and the only option for a patient's survival is dialysis or transplantation.
The purpose of this study is to provide a platform, which will enable researchers with
different areas of expertise, to investigate the molecular markers and pathways of kidney
disease and its progression. Our goal is to increase our understanding of kidney health
issues and to develop new prevention and treatment strategies which will be shared with
the medical community and the public.
Study description:
Individuals seen in the nephrology clinic at the University of Michigan will be eligible
to enroll in this study. Their clinical data will be recorded, blood and urine samples
will be collected and if a biopsy is performed as a part of their standard medical care
then a small sample will be reserved for use in the study after all pathological
evaluations required for patient care are completed. Biological samples will be available
for biochemical, molecular biological and genetic testing and for correlation of these
parameters to the individuals clinical data in future studies.
Significance:
Advances in the understanding of kidney disease may 1) provide methods of early detection
of disease, 2) identify molecular markers that will help physician prescribe the most
appropriate and beneficial treatments, 3) identify targets for the development of new
treatments, and 4) decrease the enormous cost of caring for individuals with CKD.
Aim:
Create a biobank enabling the study of kidney disease from the perspectives of
epidemiology, genetics and molecular biology.
Create a resource for the study of kidney disease, which will enable the researchers
at the University of Michigan to work collaboratively toward the elucidation of the
molecular pathways, which cause kidney disease.