Bupropion Treatment for Youth Smoking Cessation

Inclusion Criteria:

• 14 to 17 years of age

• Smoked at least 6 cigarettes per day

• Exhaled CO greater than or equal to 10 ppm

• Made at least two previous quit attempts

• Weighed at least 90 pounds

• Able to read English at least the 6th grade level

• Motivated to quit smoking as evidenced by willingness to commit to study protocolrequirements for the duration of the study

• provided active parental consent and youth assent

Exclusion Criteria:

• Current use of tobacco products other than cigarettes, unless willing to abstain fromthese products for the study duration

• Current use of other treatments for smoking cessation

• History or current diagnosis of panic disorder, psychosis, bipolar disorder, or eatingdisorder

• History of abuse or dependence on alcohol or other recreational or prescription drugsin the three months preceding the study

• Current evidence of clinical depression or Attention Deficit/Hyperactivity Disorder

• Use of any psychoactive drug and/or any type of antidepressant with in four weeks ofthe treatment phase of the study

• Predisposition to seizure or tic disorders or a personal history of a seizuredisorder, family history of seizure disorders, or treatment with medication ortherapies that increase the risk of seizures

• Significant history of or current clinical evidence of cardiovascular disease

• (Females)Pregnancy (urine pregnancy test), lactation or, if sexually active,unwillingness to use a medically acceptable form of contraception for the duration ofthe study

• Only one member of a household was allowed to participate in the study concurrently.