Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colon Cancer That Cannot Be Removed By Surgery

Last updated: March 19, 2024
Sponsor: NSABP Foundation Inc
Overall Status: Completed

Phase

2

Condition

Colon Cancer; Rectal Cancer

Rectal Cancer

Colorectal Cancer

Treatment

oxaliplatin

fluorouracil

bevacizumab

Clinical Study ID

NCT00321828
NSABP C-10
U10CA012027
CDR0000463513
  • Ages 18-120
  • All Genders

Study Summary

RATIONALE: Drugs used in chemotherapy, such as fluorouracil, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of colon cancer by blocking blood flow to the tumor. Giving combination chemotherapy together with bevacizumab may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving combination chemotherapy together with bevacizumab works in treating patients with stage IV colon cancer that cannot be removed by surgery.

Eligibility Criteria

Inclusion

DISEASE CHARACTERISTICS:

  • Histologically or cytologically confirmed adenocarcinoma of the colon

  • No histological findings other than adenocarcinoma of the colon

  • If the primary colon tumor and the metastatic lesions have been identified at the same time and it is not possible to biopsy the colonic lesion, the patient will be eligible without histologic confirmation of the primary cancer of the colon as long as other radiographic studies or scans document the characteristics of a colon cancer AND the biopsy of a metastatic site confirms diagnosis of adenocarcinoma suggestive of a primary tumor of the colon

  • Unresected primary tumor of the colon AND radiographically confirmed metastatic colon cancer (single or multiple sites of metastases) that are not considered surgically resectable for cure by chest imaging and CT scan or MRI of the abdomen within the past 4 weeks and by endoscopy within the past 8 weeks

  • Asymptomatic primary tumor

  • No obstruction, perforation, or active bleeding requiring transfusion

  • Distal extent of the tumor must be ≥ 12 cm from the anal verge on endoscopy

  • Not a candidate for curative surgical resection of all metastatic and colon primary tumors

  • No evidence of Central Nervous System (CNS) metastases

  • No recurrent local or metastatic disease after prior adjuvant therapy

  • No diagnosis of rectal carcinoma

PATIENT CHARACTERISTICS:

  • Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

  • Absolute neutrophil count ≥ 1200/mm³

  • Platelet count ≥ 100,000/mm³

  • Hemoglobin ≥ 9 g/dL

  • Aspartate aminotransferase (AST) ≤ 2.5 times upper limit of normal (ULN) (≤ 5.0 times ULN if liver metastases are present)

  • Alkaline phosphatase ≤ 3.0 times ULN (≤ 5.0 times ULN if liver metastases are present)

  • Bilirubin ≤ 1.5 times ULN (≤ 2.0 times ULN if liver metastases are present)

  • Creatinine < 1.8 mg/dL

  • Urine dipstick indicating 0-1+ protein

  • If dipstick reading is ≥ 2+, a 24-hour urine collection must demonstrate < 1 g of protein

  • Prothrombin Time and International Normalized Ratio (PT/INR) ≤ 1.5 unless the patient is on therapeutic doses of warfarin, in which case the following criteria must be met:

  • Patient must have an in-range INR (between 2 and 3) on a stable dose of warfarin

  • Patient must not have active bleeding or a pathologic condition that is associated with a high risk of bleeding

  • Patients with a history of non-colorectal malignancies must be disease free for ≥ 5 years prior to study entry and be deemed at low risk for recurrence

  • Patients with the following cancers are eligible if diagnosed and treated within the past 5 years:

  • Carcinoma in situ of the colon

  • Melanoma in situ

  • Basal cell or squamous cell carcinoma of the skin

  • Carcinoma in situ of the cervix

  • Not pregnant or nursing

  • Negative pregnancy test

  • Fertile patients must use effective contraception during and for 3 months after the completion of study therapy

  • No uncontrolled blood pressure (BP), defined as BP > 150/100 mm Hg

  • No nonmalignant systemic disease that would preclude any of the study therapy drugs, compromise the safety of the patient, or inhibit the patient's ability to participate in the study, including any of the following:

  • New York Heart Association class III or IV cardiac disease

  • Myocardial infarction within the past 6 months

  • Unstable angina within the past 6 months

  • Symptomatic arrhythmia

  • No transient ischemic attack or cerebrovascular accident within the past 6 months

  • No symptomatic peripheral vascular ischemia within the past 6 months

  • No arterial thrombotic event within the past 6 months

  • No gastroduodenal ulcer(s) determined by endoscopy to be active

  • No gastrointestinal perforation within the past 12 months

  • No serious or nonhealing wound, skin ulcer, or bone fracture

  • No significant traumatic injury within the past 28 days

  • No significant episodes of acute bleeding requiring blood transfusion within the past 6 months

  • No clinically significant (≥ grade 2) peripheral neuropathy (neurosensory or neuromotor toxicity)

  • No pulmonary fibrosis or interstitial pneumonitis by chest x-ray

  • No psychiatric or addictive disorders or other conditions that would preclude the patient from meeting study requirements

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics

  • No prior systemic chemotherapy, radiation therapy, or surgery for this malignancy

  • No prior endoscopic management of this malignancy other than biopsy, including endoscopic stent placement, fulguration, or laser treatment

  • More than 30 days since prior investigational drugs

  • More than 28 days since prior major surgical procedure or open biopsy

  • More than 7 days since prior core biopsy or other minor procedure, excluding placement of a vascular access device

  • No concurrent major surgery unrelated to intact primary colon cancer

  • No concurrent radiotherapy

  • No concurrent filgrastim (G-CSF) or pegfilgrastim as primary prophylaxis for neutropenia

  • No concurrent halogenated antiviral agents

  • No other concurrent investigational drugs

  • No other concurrent antineoplastic agents

Study Design

Total Participants: 90
Treatment Group(s): 4
Primary Treatment: oxaliplatin
Phase: 2
Study Start date:
March 01, 2006
Estimated Completion Date:
December 31, 2012

Study Description

OBJECTIVES:

Primary

  • Determine the rate of major morbidity in patients with unresectable stage IV colon cancer and a synchronous asymptomatic primary tumor treated with fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX6) in combination with bevacizumab without resection of the primary tumor.

Secondary

  • Determine the rate of specific events related to the intact primary tumor requiring hospitalization or a major intervention but not requiring surgery.

  • Determine the rate of ≥ grade 3 toxicity as defined by the Common Terminology Criteria for Adverse Events version 3.0 (CTCAE v3.0) that is related to study therapy prior to disease progression.

  • Determine overall survival of patients treated with this regimen.

OUTLINE: This is a multicenter study.

Patients receive bevacizumab IV over 30-90 minutes, oxaliplatin IV given concurrently with leucovorin calcium IV over 2 hours on day 1 and fluorouracil IV continuously over 46 hours on days 1 and 2. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed periodically for 5 years after study entry.

PROJECTED ACCRUAL: A total of 90 patients will be accrued for this study.

Connect with a study center

  • Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

    Little Rock, Arkansas 72205
    United States

    Site Not Available

  • City of Hope Comprehensive Cancer Center

    Duarte, California 91010-3000
    United States

    Site Not Available

  • Kaiser Permanente - Fremont

    Fremont, California 94538
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Hayward

    Hayward, California 94545
    United States

    Site Not Available

  • Scripps Cancer Center - San Diego

    La Jolla, California 92037
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Oakland

    Oakland, California 94611
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Redwood City

    Redwood City, California 94063
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Richmond

    Richmond, California 94801
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Roseville

    Roseville, California 95661
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Sacramento

    Sacramento, California 95825
    United States

    Site Not Available

  • South Sacramento Kaiser-Permanente Medical Center

    Sacramento, California 95823
    United States

    Site Not Available

  • Kaiser Permanente Medical Office -Vandever Medical Office

    San Diego, California 92120
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - San Francisco Geary Campus

    San Francisco, California 94115
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Santa Teresa

    San Jose, California 95119
    United States

    Site Not Available

  • Kaiser Foundation Hospital - San Rafael

    San Rafael, California 94903
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Santa Clara Kiely Campus

    Santa Clara, California 95051
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Santa Rosa

    Santa Rosa, California 95403
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - South San Francisco

    South San Francisco, California 94080
    United States

    Site Not Available

  • Kaiser Permanente Medical Facility - Stockton

    Stockton, California 95210
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Vallejo

    Vallejo, California 94589
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Walnut Creek

    Walnut Creek, California 94596
    United States

    Site Not Available

  • Tunnell Cancer Center at Beebe Medical Center

    Lewes, Delaware 19958
    United States

    Site Not Available

  • CCOP - Christiana Care Health Services

    Newark, Delaware 19713
    United States

    Site Not Available

  • Sibley Memorial Hospital

    Washington, District of Columbia 20016
    United States

    Site Not Available

  • Lakeland Regional Cancer Center at Lakeland Regional Medical Center

    Lakeland, Florida 33805
    United States

    Site Not Available

  • Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center

    Savannah, Georgia 31403-3089
    United States

    Site Not Available

  • John H. Stroger, Jr. Hospital of Cook County

    Chicago, Illinois 60612-3785
    United States

    Site Not Available

  • Decatur Memorial Hospital Cancer Care Institute

    Decatur, Illinois 62526
    United States

    Site Not Available

  • Advocate Lutheran General Cancer Care Center

    Park Ridge, Illinois 60068-1174
    United States

    Site Not Available

  • Regional Cancer Center at Memorial Medical Center

    Springfield, Illinois 62781-0001
    United States

    Site Not Available

  • St. Francis Hospital and Health Centers - Beech Grove Campus

    Beech Grove, Indiana 46107
    United States

    Site Not Available

  • Elkhart General Hospital

    Elkhart, Indiana 46515
    United States

    Site Not Available

  • Howard Community Hospital

    Kokomo, Indiana 46904
    United States

    Site Not Available

  • Center for Cancer Therapy at LaPorte Hospital and Health Services

    La Porte, Indiana 46350
    United States

    Site Not Available

  • Reid Hospital & Health Care Services

    Richmond, Indiana 47374
    United States

    Site Not Available

  • CCOP - Northern Indiana CR Consortium

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Memorial Hospital of South Bend

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Saint Joseph Regional Medical Center

    South Bend, Indiana 46617
    United States

    Site Not Available

  • McFarland Clinic, PC

    Ames, Iowa 50010
    United States

    Site Not Available

  • Holden Comprehensive Cancer Center at University of Iowa

    Iowa City, Iowa 52242-1002
    United States

    Site Not Available

  • McCreery Cancer Center at Ottumwa Regional

    Ottumwa, Iowa 52501
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Chanute

    Chanute, Kansas 66720
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Dodge City

    Dodge City, Kansas 67801
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - El Dorado

    El Dorado, Kansas 67042
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Kingman

    Kingman, Kansas 67068
    United States

    Site Not Available

  • Lawrence Memorial Hospital

    Lawrence, Kansas 66044
    United States

    Site Not Available

  • Southwest Medical Center

    Liberal, Kansas 67901
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Newton

    Newton, Kansas 67114
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Parsons

    Parsons, Kansas 67357
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Pratt

    Pratt, Kansas 67124
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Salina

    Salina, Kansas 67042
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Wellington

    Wellington, Kansas 67152
    United States

    Site Not Available

  • Associates in Womens Health, PA - North Review

    Wichita, Kansas 67208
    United States

    Site Not Available

  • CCOP - Wichita

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Medical Arts Tower

    Wichita, Kansas 67208
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Wichita

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Via Christi Cancer Center at Via Christi Regional Medical Center

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Cancer Center of Kansas, PA - Winfield

    Winfield, Kansas 67156
    United States

    Site Not Available

  • Louisville Oncology at Norton Cancer Institute - Louisville

    Louisville, Kentucky 40202
    United States

    Site Not Available

  • Harry & Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center

    Baltimore, Maryland 21237
    United States

    Site Not Available

  • Union Hospital Cancer Program at Union Hospital

    Elkton, Maryland 21921
    United States

    Site Not Available

  • Union Hospital Cancer Program at Union Hospital

    Elkton Md, Maryland 21921
    United States

    Site Not Available

  • Cancer Institute at St. Joseph Medical Center

    Towson, Maryland 21204
    United States

    Site Not Available

  • Hudner Oncology Center at Saint Anne's Hospital - Fall River

    Fall River, Massachusetts 02721
    United States

    Site Not Available

  • Josephine Ford Cancer Center at Henry Ford Hospital

    Detroit, Michigan 48202
    United States

    Site Not Available

  • Borgess Medical Center

    Kalamazoo, Michigan 49001
    United States

    Site Not Available

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007-3731
    United States

    Site Not Available

  • Lakeland Regional Cancer Care Center - St. Joseph

    Saint Joseph, Michigan 49085
    United States

    Site Not Available

  • Lakeland Regional Cancer Care Center - St. Joseph

    St. Joseph, Michigan 49085
    United States

    Site Not Available

  • Fairview Ridges Hospital

    Burnsville, Minnesota 55337
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Mercy Hospital

    Coon Rapids, Minnesota 55433
    United States

    Site Not Available

  • Fairview Southdale Hospital

    Edina, Minnesota 55435
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Unity Hospital

    Fridley, Minnesota 55432
    United States

    Site Not Available

  • Hutchinson Area Health Care

    Hutchinson, Minnesota 55350
    United States

    Site Not Available

  • Meeker County Memorial Hospital

    Lichfield, Minnesota 55355
    United States

    Site Not Available

  • Meeker County Memorial Hospital

    Litchfield, Minnesota 55355
    United States

    Site Not Available

  • HealthEast Cancer Care at St. John's Hospital

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Minnesota Oncology Hematology, PA - Maplewood

    Maplewood, Minnesota 55109
    United States

    Site Not Available

  • Hennepin County Medical Center - Minneapolis

    Minneapolis, Minnesota 55415
    United States

    Site Not Available

  • Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

    Minneapolis, Minnesota 55407
    United States

    Site Not Available

  • Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center

    Robbinsdale, Minnesota 55422-2900
    United States

    Site Not Available

  • CCOP - Metro-Minnesota

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Park Nicollet Cancer Center

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Regions Hospital Cancer Care Center

    Saint Paul, Minnesota 55101
    United States

    Site Not Available

  • United Hospital

    Saint Paul, Minnesota 55102
    United States

    Site Not Available

  • St. Francis Cancer Center at St. Francis Medical Center

    Shakopee, Minnesota 55379
    United States

    Site Not Available

  • Regions Hospital Cancer Care Center

    St. Paul, Minnesota 55101
    United States

    Site Not Available

  • Ridgeview Medical Center

    Waconia, Minnesota 55387
    United States

    Site Not Available

  • Minnesota Oncology Hematology, PA - Woodbury

    Woodbury, Minnesota 55125
    United States

    Site Not Available

  • Arch Medical Services, Incorporated at Center for Cancer Care and Research

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Missouri Baptist Cancer Center

    Saint Louis, Missouri 63131
    United States

    Site Not Available

  • CCOP - Cancer Research for the Ozarks

    Springfield, Missouri 65802
    United States

    Site Not Available

  • Hulston Cancer Center at Cox Medical Center South

    Springfield, Missouri 65807
    United States

    Site Not Available

  • St. John's Regional Health Center

    Springfield, Missouri 65804
    United States

    Site Not Available

  • CCOP - Montana Cancer Consortium

    Billings, Montana 59101
    United States

    Site Not Available

  • Hematology-Oncology Centers of the Northern Rockies - Billings

    Billings, Montana 59101
    United States

    Site Not Available

  • Northern Rockies Radiation Oncology Center

    Billings, Montana 59101
    United States

    Site Not Available

  • St. Vincent Healthcare Cancer Care Services

    Billings, Montana 59101
    United States

    Site Not Available

  • St. James Healthcare Cancer Care

    Butte, Montana 59701
    United States

    Site Not Available

  • Great Falls Clinic - Main Facility

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Great Falls, Montana 59405
    United States

    Site Not Available

  • Glacier Oncology, PLLC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Medical Oncology at KRMC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Regional Medical Center

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Community Medical Center

    Missoula, Montana 59801
    United States

    Site Not Available

  • Guardian Oncology and Center for Wellness

    Missoula, Montana 59804
    United States

    Site Not Available

  • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

    Missoula, Montana 59807
    United States

    Site Not Available

  • Montana Cancer Specialists at Montana Cancer Center

    Missoula, Montana 59807-7877
    United States

    Site Not Available

  • Methodist Estabrook Cancer Center

    Omaha, Nebraska 68114
    United States

    Site Not Available

  • St. Barnabas Medical Center Cancer Center

    Livingston, New Jersey 07039
    United States

    Site Not Available

  • Cancer Institute of New Jersey at Cooper - Voorhees

    Voorhees, New Jersey 08043
    United States

    Site Not Available

  • CCOP - Hematology-Oncology Associates of Central New York

    East Syracuse, New York 13057
    United States

    Site Not Available

  • Charles R. Wood Cancer Center at Glens Falls Hospital

    Glens Falls, New York 12801
    United States

    Site Not Available

  • Wayne Memorial Hospital, Incorporated

    Goldsboro, North Carolina 27534
    United States

    Site Not Available

  • Wake Forest University Comprehensive Cancer Center

    Winston-Salem, North Carolina 27157-1096
    United States

    Site Not Available

  • McDowell Cancer Center at Akron General Medical Center

    Akron, Ohio 44307
    United States

    Site Not Available

  • Mary Rutan Hospital

    Bellefontaine, Ohio 43311
    United States

    Site Not Available

  • Aultman Cancer Center at Aultman Hospital

    Canton, Ohio 44710-1799
    United States

    Site Not Available

  • Adena Regional Medical Center

    Chillicothe, Ohio 45601
    United States

    Site Not Available

  • Oncology Hematology Care, Incorporated - Blue Ash

    Cincinnati, Ohio 45242
    United States

    Site Not Available

  • CCOP - Columbus

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Doctors Hospital at Ohio Health

    Columbus, Ohio 43228
    United States

    Site Not Available

  • Grant Medical Center Cancer Care

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Mount Carmel Health - West Hospital

    Columbus, Ohio 43222
    United States

    Site Not Available

  • Riverside Methodist Hospital Cancer Care

    Columbus, Ohio 43214-3998
    United States

    Site Not Available

  • CCOP - Dayton

    Dayton, Ohio 45429
    United States

    Site Not Available

  • David L. Rike Cancer Center at Miami Valley Hospital

    Dayton, Ohio 45409
    United States

    Site Not Available

  • Good Samaritan Hospital

    Dayton, Ohio 45406
    United States

    Site Not Available

  • Grandview Hospital

    Dayton, Ohio 45405
    United States

    Site Not Available

  • Samaritan North Cancer Care Center

    Dayton, Ohio 45415
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Dayton

    Dayton, Ohio 45428
    United States

    Site Not Available

  • Grady Memorial Hospital

    Delaware, Ohio 43015
    United States

    Site Not Available

  • Blanchard Valley Medical Associates

    Findlay, Ohio 45840
    United States

    Site Not Available

  • Middletown Regional Hospital

    Franklin, Ohio 45005-1066
    United States

    Site Not Available

  • Wayne Hospital

    Greenville, Ohio 45331
    United States

    Site Not Available

  • Charles F. Kettering Memorial Hospital

    Kettering, Ohio 45429
    United States

    Site Not Available

  • Fairfield Medical Center

    Lancaster, Ohio 43130
    United States

    Site Not Available

  • Strecker Cancer Center at Marietta Memorial Hospital

    Marietta, Ohio 45750
    United States

    Site Not Available

  • Licking Memorial Cancer Care Program at Licking Memorial Hospital

    Newark, Ohio 43055
    United States

    Site Not Available

  • Community Hospital of Springfield and Clark County

    Springfield, Ohio 45505
    United States

    Site Not Available

  • Mercy Medical Center

    Springfield, Ohio 45504
    United States

    Site Not Available

  • UVMC Cancer Care Center at Upper Valley Medical Center

    Troy, Ohio 45373-1300
    United States

    Site Not Available

  • Mount Carmel St. Ann's Cancer Center

    Westerville, Ohio 43081
    United States

    Site Not Available

  • Clinton Memorial Hospital

    Wilmington, Ohio 45177
    United States

    Site Not Available

  • Ruth G. McMillan Cancer Center at Greene Memorial Hospital

    Xenia, Ohio 45385
    United States

    Site Not Available

  • Genesis - Good Samaritan Hospital

    Zanesville, Ohio 43701
    United States

    Site Not Available

  • Bryn Mawr Hospital

    Bryn Mawr, Pennsylvania 19010
    United States

    Site Not Available

  • Riddle Memorial Hospital Cancer Center

    Media, Pennsylvania 19063
    United States

    Site Not Available

  • Cancer Center of Paoli Memorial Hospital

    Paoli, Pennsylvania 19301-1792
    United States

    Site Not Available

  • Kimmel Cancer Center at Thomas Jefferson University - Philadelphia

    Philadelphia, Pennsylvania 19107-5541
    United States

    Site Not Available

  • Allegheny Cancer Center at Allegheny General Hospital

    Pittsburgh, Pennsylvania 15212
    United States

    Site Not Available

  • Hematology and Oncology Associates of Northeastern Pennsylvania

    Scranton, Pennsylvania 18508
    United States

    Site Not Available

  • Mount Nittany Medical Center

    State College, Pennsylvania 16803
    United States

    Site Not Available

  • Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center

    Upland, Pennsylvania 19013
    United States

    Site Not Available

  • CCOP - Main Line Health

    Wynnewood, Pennsylvania 19096
    United States

    Site Not Available

  • Lankenau Cancer Center at Lankenau Hospital

    Wynnewood, Pennsylvania 19096
    United States

    Site Not Available

  • CCOP - Greenville

    Greenville, South Carolina 29615
    United States

    Site Not Available

  • Avera Cancer Institute

    Sioux Falls, South Dakota 57105
    United States

    Site Not Available

  • Medical X-Ray Center, PC

    Sioux Falls, South Dakota 57105
    United States

    Site Not Available

  • Sanford Cancer Center at Sanford USD Medical Center

    Sioux Falls, South Dakota 57117-5039
    United States

    Site Not Available

  • Joe Arrington Cancer Research and Treatment Center

    Lubbock, Texas 79410-1894
    United States

    Site Not Available

  • Fletcher Allen Health Care - University Health Center Campus

    Burlington, Vermont 05401
    United States

    Site Not Available

  • Danville Regional Medical Center

    Danville, Virginia 24541
    United States

    Site Not Available

  • West Virginia University Health Sciences Center - Charleston

    Charleston, West Virginia 25304
    United States

    Site Not Available

  • Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital

    Parkersburg, West Virginia 26102
    United States

    Site Not Available

  • Marshfield Clinic - Marshfield Center

    Marshfield, Wisconsin 54449
    United States

    Site Not Available

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