IRIS Followed by mFOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer

Inclusion Criteria:

1. Histological diagnosis of colorectal cancer. 2） Age: 18 - 75 years. 3） No priorchemotherapy 4） ECOG Performance Status 0 to 2 5) A life expectancy of at least 3 months 6)Adequate function of major organs (bone marrow, heart, lungs, liver etc.). WBC ≧3,500/mm3and Neutrophil ≧2,000/mm3. Hb ≧10.0 g/dl. Platelet count ≧100,000/mm3. AST and ALT ≦2.5times the upper limit of normal (excluding liver metastasis). T-Bil ≦1.5 mg/dl. Creatinine ≦1.5 mg/ dl. 7).Patients must have the ability to understand and the willingness to sign awritten informed contact document.

Exclusion Criteria:

1. Patients receiving blood transfusion, blood derivatives or granulocyte-colonystimulating factor within 7days prior to entering the study.

2. Patients can not have oral intake

3. Patients receiving Flucytosine treatment

4. Patients with severe pleural effusion or ascites.

5. Patients who have brown brain metastasis

6. Patients with diarrhea 4 or more times per day

7. Patients with active gastrointestinal bleeding.

8. Patients with intestinal obstruction

9. Patients with active infection.

10. Patients with serious pulmonary disease (such as interstitial pneumonia, pulmonaryfibrosis, pulmonary emphysema)

11. Patients with serious complications (such as intestinal paralysis, intestinalobstruction, interstitial pneumonia or pulmonary fibrosis, uncontrolled diabetesmellitus, heart failure, renal failure, or hepatic failure).

12. Patients with significant cardiac disease.

13. Patients with active multiple cancer.

14. Patients with neuropathy ≥ grade 2

15. Patients who are pregnant, are of childbearing potential, or breast-feeding.

16. Patients with severe mental disorder.

17. Patients with a history of serious allergic reaction.

18. Judged to be ineligible for this protocol by the investigation.