RATe Control in Atrial Fibrillation

Last updated: May 11, 2014
Sponsor: Asker & Baerum Hospital
Overall Status: Completed

Phase

3

Condition

Chest Pain

Arrhythmia

Cardiac Disease

Treatment

N/A

Clinical Study ID

NCT00313157
2005-004221-26
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to compare the effect of metoprolol, verapamil, diltiazem and carvedilol on ventricular rate, working capacity and quality of life in patients with chronic atrial fibrillation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Persistent or permanent atrial fibrillation with ventricular rate > 80/min at restand/or > 100/min average at daytime.

  • Male or female, age > 18.

Exclusion

Exclusion Criteria:

  • Hypersensitivity or contraindication to metoprolol, verapamil, diltiazem orcarvedilol.

  • Coronary heart disease or heart failure

  • Systolic blood pressure < 100 mmHg

  • AV-conduction disturbance

  • Severe hepatic or renal dysfunction

  • Thyrotoxicosis

  • Ongoing treatment with Digitalis

  • Pregnancy or lactation

Study Design

Total Participants: 80
Study Start date:
April 01, 2006
Estimated Completion Date:
September 30, 2010

Study Description

This is a randomised, single blinded, cross-over study comparing the efficacy of metoprolol 100 mg o.d., verapamil 240 mg o.d., diltiazem 360 mg o.d. and carvedilol 25 mg o.d. in reducing ventricular rate in atrial fibrillation. A total of 60 patients will be included, with a minimum of 20 women.Patients will receive each of the drug regimens in a random sequence. Each regimen will be administered for 3 weeks, ensuring that steady-state drug concentration will be attained and to provide an adequate washout of the previous treatment. Following each regimen, exercise ECG and Holter registration will be performed and patients will undergo laboratory evaluation and complete QoL-forms. They will then be started on the next randomly assigned treatment regimen, until the entire sequence of treatment schedules is completed.

Connect with a study center

  • Vestre Viken Hospital Trust, Baerum Hospital

    Rud, Akershus 1309
    Norway

    Site Not Available

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