Comparing Gabapentin and Amitriptyline for the Treatment of Neuropathic Pain in Children and Adolescents

Last updated: October 19, 2020
Sponsor: The Hospital for Sick Children
Overall Status: Completed

Phase

3

Condition

Pain

Pain (Pediatric)

Treatment

N/A

Clinical Study ID

NCT00312260
1000008259
  • Ages 8-17
  • All Genders

Study Summary

The objective of the study is to compare the efficacy of gabapentin and amitriptyline for treating neuropathic pain in children in a randomized controlled trial.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 8 - 17 years of age

  • Diagnosis of neuropathic pain

Exclusion

Exclusion Criteria:

  • Additional health problems

  • Lactose intolerant

  • Unable to swallow size 0 gelatin capsules

  • Pregnant

  • Unable to speak English

Study Design

Total Participants: 34
Study Start date:
April 01, 2006
Estimated Completion Date:
March 02, 2017

Study Description

Clinical experience and case reports suggest that both amitriptyline and gabapentin are effective treatments for neuropathic pain in children; however we do not know which drug is more effective for specific pain conditions or for specific children. This study will be the first prospective, randomized double-blind controlled trial directly comparing gabapentin and amitriptyline for the treatment of neuropathic pain in a paediatric population. We will also study the time course for pain reduction and evaluate changes in children's physical function, mood, and sleep. This information is needed to determine which drug is better for which children and which pain conditions.

Connect with a study center

  • The Hospital for Sick Children

    Toronto, Ontario M5G 1X8
    Canada

    Site Not Available

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