Randomized Study on Adjuvant Chemotherapy and Adjuvant Chemo-Immunotherapy in Colon Carcinoma Dukes C

Last updated: March 31, 2006
Sponsor: Austrian Breast & Colorectal Cancer Study Group
Overall Status: Completed

Phase

3

Condition

Colorectal Cancer

Colon Cancer

Treatment

N/A

Clinical Study ID

NCT00309530
ABCSG 90
  • Ages 18-80
  • All Genders

Study Summary

This clinical investigation examined the effectivity 5-fluorouracil, of adding levamisol or interferon to 5-fluorouracil, and of a 5-fluorouracil/levamisol/interferon triple combination, in terms of recurrence-free and overall survival in curatively operable colon carcinoma Stage III.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with histologically verified, curatively operated colon carcinoma Stage III (R0, T1-4, N1-3, M0)

  • Age: less than 80 years

  • WHO Performace Status > 2

  • Adequate bone marrow reserve

  • Informed consent

Exclusion

Exclusion Criteria:

  • Rectal cancer

  • R1, R2, carcinosis peritonei

  • Start of chemo- or chemo-immunotherapy > 42 days postop; other adjuvant radiotherapy,chemotherapy or immunotherapy

  • Serious concomitant disease, in particular chronically inflammatory large intestine,cardiopathic disease, malignant second carcinoma

Study Design

Total Participants: 598
Study Start date:
October 01, 1990
Estimated Completion Date:

Connect with a study center

  • Hospital Guessing

    Guessing, Burgenland 7540
    Austria

    Site Not Available

  • Hospital Oberpullendorf

    Oberpullendorf, Burgenland 7350
    Austria

    Site Not Available

  • Hospital BHB St. Veit/Glan, Surgery

    St. Veit a. d. Glan, Carinthia 9330
    Austria

    Site Not Available

  • State Hospital Wolfsberg

    Wolfsberg, Carinthia 9400
    Austria

    Site Not Available

  • Medical University of Graz, Oncology

    Graz, Styria 8036
    Austria

    Site Not Available

  • State Hospital Leoben, Surgery

    Leoben, Styria 8700
    Austria

    Site Not Available

  • Hospital St. Vinzenz

    Zams, Tyrol 6511
    Austria

    Site Not Available

  • State Hospital Kirchdorf

    Kirchdorf, Upper Austria 4560
    Austria

    Site Not Available

  • General Hospital Linz

    Linz, Upper Austria 4020
    Austria

    Site Not Available

  • Hospital BHB Linz

    Linz, Upper Austria 4020
    Austria

    Site Not Available

  • State Hospital Voecklabruck, Internal Medicine

    Voecklabruck, Upper Austria 4840
    Austria

    Site Not Available

  • Hospital Kreuzschwestern Wels

    Wels, Upper Austria 4600
    Austria

    Site Not Available

  • State Hospital Feldkirch

    Feldkirch, Vorarlberg 6807
    Austria

    Site Not Available

  • Paracelsus Medical University Salzburg - Oncology

    Salzburg, 5020
    Austria

    Site Not Available

  • Medical University Vienna, General Hospital

    Vienna, 1090
    Austria

    Site Not Available

  • Wilheminenspital, Internal Medicin I

    Vienna, 1160
    Austria

    Site Not Available

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