Study of Amiodarone Given Before Lung Surgery to Prevent Atrial Fibrillation After Lung Resection

Last updated: March 20, 2017
Sponsor: Beth Israel Deaconess Medical Center
Overall Status: Terminated

Phase

3

Condition

Lung Cancer

Non-small Cell Lung Cancer

Arrhythmia

Treatment

N/A

Clinical Study ID

NCT00300495
2005P000376
  • Ages > 18
  • All Genders

Study Summary

Atrial fibrillation is a very common complication of pulmonary resection. Patients who develop atrial fibrillation require additional treatment and are more likely to stay in the hospital for longer period of time increasing the costs associated with the operation. We propose a randomized controlled trial to see if oral amiodarone given for one week before surgery can prevent atrial fibrillation after pulmonary resection. We plan to evaluate the incidence of atrial fibrillation in patients who received preoperative amiodarone and compare them to the incidence of atrial fibrillation in patients who did not received preoperative amiodarone.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Resectable lung nodule or mass

Exclusion

Exclusion Criteria:

  • Allergy to amiodarone

  • Currently taking amiodarone

  • Documented atrial fibrillation within past 12 months

  • Known pulmonary fibrosis

  • Known hepatic dysfunction

  • Thyroid disease

  • 2nd or 3rd degree heart block

  • Severe SA node disease

  • Bradycardia-induced syncope

  • Pregnancy

Study Design

Total Participants: 19
Study Start date:
February 01, 2006
Estimated Completion Date:
October 13, 2009

Study Description

Atrial fibrillation is a very common complication of pulmonary resection. Patients who develop atrial fibrillation require additional treatment and are more likely to stay in the hospital for longer period of time increasing the costs associated with the operation.

We propose a study to see if oral amiodarone given for one week before surgery can prevent atrial fibrillation after pulmonary resection. We plan to evaluate the incidence of atrial fibrillation in patients who received preoperative amiodarone and compare them to the incidence of atrial fibrillation in patients who did not received preoperative amiodarone.

Connect with a study center

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts 02215
    United States

    Site Not Available

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