Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder

Inclusion Criteria:

• Child or adolescent must be 7 to 18 years of age (inclusive) when informed consent isobtained.

• Must meet full criteria for Tourette's Disorder or chronic motor tic disorder.

• Must have failed to respond to an adequate trial, as determined by the investigator,of clonidine, guanfacine, or neuroleptic medication in the past.

• Tics are causing significant distress or impairment, as determined by parent/subjectand principal investigator, on current treatment regimen.

• Laboratory results, including serum chemistries, hematology, and urinalysis, must showno significant abnormalities (significant is defined as laboratory values requiringacute medical intervention).

• Must be able to swallow pills.

• Must be of normal intelligence in the judgment of the investigator.

• Must possess an educational level, degree of understanding and command of the Englishlanguage to enable them to communicate suitably with the investigator and studycoordinator, and to understand the nature of the study.

• Subjects and their legal representatives must be considered reliable.

• Written informed consent of parents and subjects (ages 18 and above) and assent ofsubjects ages 7-17 will be obtained.

Exclusion Criteria:

• Organic brain disease, for example, traumatic brain injury residua.

• Mental retardation as defined by the DSM-IV-TR.

• A history of seizure disorder (other than febrile seizure).

• A history of Sydenham's Chorea.

• Autism, schizophrenia, other psychotic disorder, or bipolar disorder.

• A primary diagnosis of a major mood disorder that requires ongoing psychiatrictreatment.

• A neurological disorder other than a tic disorder.

• A major medical illness.

• Females who are of child bearing age who are unwilling to use birth control or who arepregnant, as determined by serum pregnancy test at baseline assessment, or lactating.

• Have a past or current history of substance dependence and/or a current history ofsubstance abuse or who fail baseline toxic screen.

• Have any clinically significant abnormal laboratory result at baseline screeningincluding EKG, or blood tests.

• Have a history of ongoing or previously undisclosed child abuse (risk of removal fromhome would not allow for consistent caretaker ratings).