Retigabine (Adjunctive Therapy) Efficacy and Safety Study for Partial Onset Refractory Seizures in Epilepsy

Inclusion Criteria:

• Diagnosis of refractory epilepsy with simple or complex partial onset seizures with orwithout secondary generalization

• 28-day partial seizure frequency rate of four or more partial seizures over the 8-weekbaseline phase

• Currently treated with up to three established AEDs

• Vagal Nerve Stimulator may be included

Exclusion Criteria:

• Existing medical or psychiatric condition which could affect patient's health orcompromise ability to participate in the study

• Clinically significant abnormalities on physical exam, vital signs, ECG, or liverfunction tests

• Impaired renal function (creatinine clearance less than 50 mL/minute)

• Evidence of progressive central nervous disease, lesion, or encephalopathy

• History of primary generalized seizures

• History of clustering or flurries or status epilepticus within 12 months of studyentry