Comparing the Safety and Effectiveness of Topiramate With the Safety and Effectiveness of Amitriptyline in Preventing Migraine Headaches

Last updated: June 8, 2011
Sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Overall Status: Completed

Phase

3

Condition

Oral Facial Pain

Chronic Pain

Headaches

Treatment

N/A

Clinical Study ID

NCT00210821
CR004666
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to compare the effectiveness and safety of two treatment regimens in preventing migraines. The antidepressant amitriptyline has been used successfully to prevent migraine headaches.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Migraine headache for at least 6 months, with 3 to 12 headaches a month for theprevious 3 months

  • no more than 15 headache days in the previous month before study start

  • no heart rhythm problems or neurologic problems

  • women must not be pregnant and must use birth control

Exclusion

Exclusion Criteria:

  • Cannot have failed at least 2 previous trials of migraine prevention drugs

  • cannot have failed a previous trial of topiramate or amitriptyline

  • no cluster headaches

  • no migraine with aura without headache

  • no pain that is worse than the migraine pain

Study Design

Total Participants: 347
Study Start date:
February 01, 2004
Estimated Completion Date:
November 30, 2005

Study Description

People who suffer from migraines have many prescription medications to choose from, both to treat the migraine and to prevent it from starting. However, many patients have not had success in finding the drug that helps them best. Amitriptyline, an antidepressant, has been used successfully for many years to prevent migraine headaches. This study will compare the effectiveness of amitriptyline with the effectiveness of topiramate, an anti-seizure drug, in preventing migraines. The safety of both drugs will also be assessed. The objective of the study is to demonstrate that topiramate will be at least as effective as amitriptyline in preventing migraines. During the first 4 weeks of the study, topiramate or amitriptyline will be increased by 25 mg per week up to a total dose of 100 mg per day or up to the maximum tolerated dose, whichever is less. Treatment will continue at 100 mg per day for 22 weeks.