Dopamine Transporter Scintigraphy Imaging (DAT-Imaging) in Patients With Lewy Body Dementia

Last updated: May 15, 2007
Sponsor: GE Healthcare
Overall Status: Completed

Phase

3

Condition

Vascular Dementia

Vascular Diseases

Parkinson's Disease

Treatment

N/A

Clinical Study ID

NCT00209456
PDT301
  • Ages 55-90
  • All Genders

Study Summary

The study is designed to determine the diagnostic efficacy of the visual assessment of SPECT scans in differentiating between probable dementia with Lewy Bodies (DLB) and non-DLB dementia subjects determined by the clinical diagnosis of an independent expert consensus panel used as the standard of truth.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Subjects must be adults between 55 to 90 years of age with an established diagnosisfor dementia in accordance with DSM-IV criteria and have to fulfil at least one of thefollowing: The ICC criteria for probable and possible DLB, the National Institute ofNeurological and Communicative Disorders and Stroke and Alzheimer Disease and RelatedDisorders Association (NINCDS-ADRDA) for Alzheimer’s Disease (AD), or the NationalInstitute of Neurological and Communicative Disorders and Association InternationalePour la Recherche et l’Enseignement en Neurosciences (NINCS-AIREN) for VascularDementia (VaD).

Exclusion

Exclusion Criteria:

  • Subjects are not eligible if they have a Mini Mental State Examination (MMSE) score of <10 and use medication known or suspected to interact with the striatal uptake DaTSCANto the dopamine transporter.

  • Furthermore subjects are not eligible if they were diagnosed with idiopathicParkinson’s Disease (PD), with persistent severe depression, normal pressurehydrocephalus, multiple system atrophy, cortico-basal degeneration or Huntington’sChorea Disease.

Study Design

Total Participants: 326
Study Start date:
November 01, 2003
Estimated Completion Date:

Study Description

GEHC had decided notto provide this detail

Connect with a study center

  • Amersham Buchler GmbH Co. KG

    Ismaning,
    Germany

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.