Dopamine Transporter Scintigraphy Imaging (DAT-Imaging) in Patients With Lewy Body Dementia

Inclusion Criteria:

• Subjects must be adults between 55 to 90 years of age with an established diagnosisfor dementia in accordance with DSM-IV criteria and have to fulfil at least one of thefollowing: The ICC criteria for probable and possible DLB, the National Institute ofNeurological and Communicative Disorders and Stroke and Alzheimer Disease and RelatedDisorders Association (NINCDS-ADRDA) for Alzheimer’s Disease (AD), or the NationalInstitute of Neurological and Communicative Disorders and Association InternationalePour la Recherche et l’Enseignement en Neurosciences (NINCS-AIREN) for VascularDementia (VaD).

Exclusion Criteria:

• Subjects are not eligible if they have a Mini Mental State Examination (MMSE) score of <10 and use medication known or suspected to interact with the striatal uptake DaTSCANto the dopamine transporter.

• Furthermore subjects are not eligible if they were diagnosed with idiopathicParkinson’s Disease (PD), with persistent severe depression, normal pressurehydrocephalus, multiple system atrophy, cortico-basal degeneration or Huntington’sChorea Disease.