The Effects of Acute Administration of Bupropion on Neural Substrates Underlying Hedonic Capacity

Inclusion Criteria:

• Absence of medical, neurological, and psychiatric illness (including alcohol andsubstance abuse)

• Non-Smoker

• Right-handed (Chapman and Chapman 1987)

• Ability to provide informed consent

Exclusion Criteria:

• Predisposition to seizure (e.g. family history of a seizure disorder, history of headtrauma) or current use of medications that lower the seizure threshold

• History or current diagnosis of anorexia or bulimia

• Alcohol or substance abuse within the past year

• Current usage of Wellbutrin or Zyban or other drugs that contain bupropion

• Recent discontinuation of alcohol or sedatives (including benzodiazepines)

• Use of (in the last 2 weeks) medications that may have antidepressant properties (ex.some herbal supplements)

• Known allergies to bupropion

• Currently lactating, pregnant or believe you are likely to be pregnant (enrolledsubjects who are not using reliable contraception and have engaged in sexualintercourse since their last menstrual period will be given a self-administeredpregnancy test.)

• Left-handed/ambidextrous

• Evidence of neurological illness

• Serious suicide or homicide risk Concomitant medications other than those listed in the exclusion criteria will beconsidered on an individual basis. Oral contraceptives will be allowed.