Phase 2 Clinical Study in Rheumatoid Arthritis With an Investigational Oral p38 MAP Kinase Inhibitor VX-702

Last updated: December 5, 2007
Sponsor: Vertex Pharmaceuticals Incorporated
Overall Status: Completed

Phase

2

Condition

Rheumatoid Arthritis

Arthritis And Arthritic Pain

Joint Injuries

Treatment

N/A

Clinical Study ID

NCT00205478
VX04-702-301
  • Ages 18-75
  • All Genders

Study Summary

The purpose of this study is to assess the clinical activity and safety of two doses of VX-702 compared to placebo in subjects with moderate to severe Rheumatoid Arthritis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults with active rheumatoid arthritis for greater than 6 months and evidence ofinflammation.

Exclusion

Exclusion Criteria:

  • Subjects who have conditions precluding the use of cytokine inhibitors or subjects whorequire DMARDs other than hydroxychloroquine or sulfasalazine are excluded.

Study Design

Total Participants: 300
Study Start date:
June 01, 2005
Estimated Completion Date:
February 28, 2006

Connect with a study center

  • Medical University - Sofia

    Sofia,
    Bulgaria

    Site Not Available

  • Military Medical Academy - Sofia

    Sofia,
    Bulgaria

    Site Not Available

  • Transport Hospital

    Sofia,
    Bulgaria

    Site Not Available

  • MBAL "Stara Zagora" EAD

    Stara Zagora,
    Bulgaria

    Site Not Available

  • Thalassotherapia

    Opatija,
    Croatia

    Site Not Available

  • KBC Osijek Ambulanta za bol

    Osijek,
    Croatia

    Site Not Available

  • University Hospital Centre Zagreb

    Zagreb,
    Croatia

    Site Not Available

  • University Hospital U Sv.Anny

    Brno,
    Czech Republic

    Site Not Available

  • University Hospital Kralovske Vinohrady

    Praha 10,
    Czech Republic

    Site Not Available

  • SZZ-Jizni Mesto II

    Praha 11,
    Czech Republic

    Site Not Available

  • Institute of Rheumatology

    Praha 2,
    Czech Republic

    Site Not Available

  • Rheumatology Out-patient Department

    Praha 6,
    Czech Republic

    Site Not Available

  • Institute of Rheumatology

    Beograd,
    Former Serbia and Montenegro

    Site Not Available

  • Institute of Rheumatology - Niska Banja

    Niska Banja,
    Former Serbia and Montenegro

    Site Not Available

  • Clinical Center Zemun

    Zemun,
    Former Serbia and Montenegro

    Site Not Available

  • Szpital Specjalistyczny Nr 1

    Bytom,
    Poland

    Site Not Available

  • Wojewodzki Szpital Zespolony

    Elblag,
    Poland

    Site Not Available

  • Malopolskie Centrum Medyczne

    Krakow,
    Poland

    Site Not Available

  • "Gabinety Profesorow" Prywatna Praktyka

    Lublin,
    Poland

    Site Not Available

  • Instytut Medycyny Wsi im. Witolda Chodzki

    Lublin,
    Poland

    Site Not Available

  • Wojewodzki Zespoￅﾂ Reumatologiczny im.

    Sopot,
    Poland

    Site Not Available

  • NZOZ "Nasz Lekarz" Praktyka Grupowa Lekarzy

    Torun,
    Poland

    Site Not Available

  • Okregowy Szpital Kolejowy

    Wroclaw,
    Poland

    Site Not Available

  • ZOZ Zyrardow

    Zyrardow,
    Poland

    Site Not Available

  • Pirogov City Clinical Hospital #1

    Moscow,
    Russian Federation

    Site Not Available

  • State Institute of Rheumatology of RAMS

    Moscow,
    Russian Federation

    Site Not Available

  • State Clinical Immunology Research

    Novosibirsk,
    Russian Federation

    Site Not Available

  • Ryazan Regional Clinical Cardiologic

    Ryazan,
    Russian Federation

    Site Not Available

  • Saint Petersburg Clinical Hospital

    Saint Petersburg,
    Russian Federation

    Site Not Available

  • Saint-Petersburg City Hospital

    Saint-Petersburg,
    Russian Federation

    Site Not Available

  • Saint-Petersburg Medical Academy

    Saint-Petersburg,
    Russian Federation

    Site Not Available

  • Saratov Regional Clinical Hospital

    Saratov,
    Russian Federation

    Site Not Available

  • City Pokrovskaya Hospital

    St. Petersburg,
    Russian Federation

    Site Not Available

  • EVIDENCE Clinical and Pharmaceutical Research

    St. Petersburg,
    Russian Federation

    Site Not Available

  • Leningrad Regional Hospital

    St. Petersburg,
    Russian Federation

    Site Not Available

  • National Institute of Rheumatic Diseases

    Piestany,
    Slovakia

    Site Not Available

  • Clinical Center Ljubljana

    Ljubljana,
    Slovenia

    Site Not Available

  • Dniepropetrovsk State Medical Academy

    Dniepropetrovsk,
    Ukraine

    Site Not Available

  • Donetsk State Medical University

    Donetsk,
    Ukraine

    Site Not Available

  • Institute of Cardiology of Ukranian AMS

    Kiev,
    Ukraine

    Site Not Available

  • Institute of Gerontology of Ukrainian AMS

    Kiev,
    Ukraine

    Site Not Available

  • SanaClis s.r.o.

    Kiev,
    Ukraine

    Site Not Available

  • Zaporizhya Medical Institute

    Zaporizhya,
    Ukraine

    Site Not Available

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