Cefpodoxime vs Ciprofloxacin for Acute Cystitis

Phase

N/A

Condition

Urinary Incontinence

Gynecological Infections

Enuresis

Treatment

N/A

Clinical Study ID

NCT00194532

27085-D

Ages 18-45
Female
Accepts Healthy Volunteers

Study Summary

Urinary tract infection (UTI) is a very common problem in young healthy women, afflicting approximately one-half of women by their late 20s. One of the most common antibiotics used to treat UTIs is ciprofloxacin, usually for a total of three days. However, increasing resistance to this antibiotic has raised concerns about its overuse for cystitis and generated interest in alternative agents. An alternative antibiotic which is approved for use in UTIs is cefpodoxime. However, there are few studies evaluating the efficacy and tolerance of this compound when given in a 3-day regimen as is commonly used for treatment of UTI. The major purpose of this study is to assess the efficacy and tolerance of a 3-day regimen of cefpodoxime versus ciprofloxacin for treatment of acute uncomplicated cystitis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Nonpregnant females in good general health with symptoms of acute cystitis

Exclusion

Exclusion Criteria:

Pregnant,lactating, or not regularly contracepting: known anatomic abnormalities ofthe urinary tract; use of prophylactic antibiotics; history of allergy or intoleranceto any of the study drugs; recent (>2 weeks)exposure to an oral or parenteralantimicrobial; or history of UTI in the previous 1 month

Study Design

June 01, 2005

February 28, 2009

Study Description

Procedures subjects will undergo once they have read and signed the consent are:

Questions about their medical and sexual history and current symptoms of UTI. They will be asked to provide a urine and peri-urethral sample and then are randomly assigned to one of the two treatment groups.They will be given a sheet to record symptoms at home. They will be asked to return to the clinic in 5-9 and 28-30 days after completing antibiotic therapy.Follow-up questions will be asked and urine and peri-urethral will be self collected at each visit.

Connect with a study center

University of Miami Miller School of Medicine
Miami, Florida 33136
United States
Site Not Available
University of Washington
Seattle, Washington 98195
United States
Site Not Available

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