Coronary Care Caffeine: Influence of Coffee on Heart Rate Post Myocardial Infarction

Last updated: October 2, 2009
Sponsor: The Royal Bournemouth Hospital
Overall Status: Completed

Phase

N/A

Condition

Occlusions

Coronary Artery Disease

Congestive Heart Failure

Treatment

N/A

Clinical Study ID

NCT00137098
BDEC Caffeine
  • Ages 18-80
  • All Genders

Study Summary

Sudden cardiac death due to a heart rhythm disturbance after a heart attack (myocardial infarction) is a common cause of death. It is well documented that sudden cardiac death after a myocardial infarct (MI) is associated with low or poor heart rate variability (HRV). HRV is a measure of beat-to-beat changes in heart rate, with a greater variation associated with a "healthier" heart. The effect of caffeine on HRV in patients at high risk for sudden cardiac death is unknown. We, the investigators at the Royal Bournemouth Hospital, aim to study the effect of coffee or tea on HRV after MI.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • ST-segment elevation (trans-mural) MI; sinus rhythm.

  • Age < 80 years.

Exclusion

Exclusion Criteria:

  • Cardiogenic shock

  • Nothing by Mouth (NBM)

  • Caffeine intolerance

  • Atrial fibrillation, temporary or permanent pacing

  • Complete heart block, bundle branch block, severe left ventricular impairment, non-STsegment MI/acute coronary syndrome

Study Design

Total Participants: 100
Study Start date:
September 01, 2003
Estimated Completion Date:
January 31, 2006

Study Description

120 post MI patients on CCU will be studied during the first week of admission. Patients will be categorised using the following criteria: Infarct size and site; PMH; Co-morbidities; Drugs; Regular caffeine ingestion.

Patients will be randomised to receive either caffeinated or de-caffeinated coffee or tea during admission. HRV will be assessed by non-invasive Holter-monitoring on the fifth day. Salivary caffeine concentration will be assessed concurrently to assess compliance.

Connect with a study center

  • Royal Bournemouth Hospital

    Bournemouth, Dorset BH7 7DW
    United Kingdom

    Site Not Available

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