Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer's Disease

Phase

Condition

Alzheimer's Disease

Memory Loss

Dementia

Treatment

N/A

Clinical Study ID

NCT00096473

E2020-A001-315

Ages > 50
All Genders

Study Summary

Donepezil hydrochloride (Aricept) has been approved to treat symptoms associated with mild to moderate Alzheimer's disease (AD). Aricept has been shown to improve the memory and thinking abilities, activities of daily living and global function in patients. The purpose of the study is to further investigate the effectiveness and safety of donepezil in patients with severe Alzheimer's disease.

Donepezil is thought to work in the brain by increasing the levels of an important brain chemical called acetylcholine. This chemical helps a person's memory to work better.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Clinically diagnosed Alzheimer's Disease with MMSE score 1~12
Have not been treated by any medication for Alzheimer's Disease in past 3 months
Live in community or Assisted Living Facility
Healthy or with chronic diseases that are medically controlled or stabilized
Able to swallow tablets

Exclusion

Exclusion Criteria:

Any primary neurological or psychiatric diagnosis (including depressive disorder)other than Alzheimer's Disease
Dementia caused by organic diseases other than Alzheimer's Disease

Study Design

January 01, 2001

September 30, 2005

Connect with a study center

Randwick, New South Wales
Australia
Site Not Available
Brisbane, Queensland
Australia
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Woodville South, South Australia
Australia
Site Not Available
Heidelberg West, Victoria
Australia
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Nedlands, Western Australia
Australia
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Toronto, Ontario
Canada
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Hôpital Broca-La Rochefoucauld
Paris,
France
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Belfast,
Ireland
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St. Leonards on Sea, East Sussex
United Kingdom
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West End, Southampton
United Kingdom
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Swindon, Wilshire
United Kingdom
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Bath,
United Kingdom
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Blackpool,
United Kingdom
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Bradford,
United Kingdom
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Northport, Alabama
United States
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Phoenix, Arizona
United States
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Sun City, Arizona
United States
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Tucson, Arizona
United States
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San Francisco, California
United States
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Santa Monica, California
United States
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Torrance, California
United States
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Denver, Colorado
United States
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Ft. Lauderdale, Florida
United States
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Ft. Myers, Florida
United States
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North Miami, Florida
United States
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St. Petersburg, Florida
United States
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Atlanta, Georgia
United States
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Chicago, Illinois
United States
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New Orleans, Louisiana
United States
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Springfield, Massachusetts
United States
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Long Branch, New Jersey
United States
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Piscataway, New Jersey
United States
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New Hyde Park, New York
United States
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Greenville, North Carolina
United States
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Raleigh, North Carolina
United States
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Centerville, Ohio
United States
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Oklahoma City, Oklahoma
United States
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Medford, Oregon
United States
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Portland, Oregon
United States
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Jenkintown, Pennsylvania
United States
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Austin, Texas
United States
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Houston, Texas
United States
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