Interstitial Brachytherapy With or Without External-Beam Radiation Therapy in Treating Patients With Prostate Cancer

Last updated: February 28, 2023
Sponsor: Radiation Therapy Oncology Group
Overall Status: Completed

Phase

3

Condition

Prostate Cancer

Prostate Cancer, Early, Recurrent

Prostate Disorders

Treatment

N/A

Clinical Study ID

NCT00063882
RTOG 0232
NCI-2009-01091
CDR0000288823
  • Ages 18-120
  • Male

Study Summary

RATIONALE: Radiation therapy uses high-energy x-rays and other sources to damage tumor cells. Interstitial brachytherapy uses radioactive material placed directly into or near a tumor to kill tumor cells. Combining interstitial brachytherapy with external-beam radiation therapy may kill more tumor cells. It is not yet known whether interstitial brachytherapy is more effective with or without external-beam radiation therapy in treating prostate cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of interstitial brachytherapy with or without external-beam radiation therapy in treating patients who have prostate cancer.

Eligibility Criteria

Inclusion

DISEASE CHARACTERISTICS:

  • Histologically confirmed adenocarcinoma of the prostate

  • T1c-T2b, N0, M0

  • Intermediate-risk disease, as defined by 1 of the following:

  • Gleason score < 7 AND prostate-specific antigen (PSA) 10-20 ng/mL

  • Gleason score 7 AND PSA < 10 ng/mL

  • No evidence of distant metastases

  • Prostate volume ≤ 60 cc by transrectal ultrasonography

  • American Urological Association voiding symptom score no greater than 15 (alpha blockers allowed)

PATIENT CHARACTERISTICS:

Age

  • 18 and over

Performance status

  • Zubrod 0-1

Life expectancy

  • Not specified

Hematopoietic

  • Not specified

Hepatic

  • Not specified

Renal

  • Not specified

Other

  • Patients must use effective contraception

  • No other malignancy within the past 5 years except basal cell or squamous cell skin cancer or carcinoma in situ at any other site

  • No major medical or psychiatric illness that would preclude study therapy

  • No hip prosthesis

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • Not specified

Chemotherapy

  • No prior chemotherapy

Endocrine therapy

  • Prior neoadjuvant hormonal therapy allowed provided the following are true:

  • Therapy was initiated within 2-6 months of study enrollment

  • Therapy was no more than 6 months in duration

  • Use of 5-alpha reductase inhibitors (e.g., finasteride) is discontinued before registration

  • No concurrent hormonal therapy

Radiotherapy

  • No prior pelvic radiotherapy

Surgery

  • No prior radical surgery for prostate cancer

  • No prior transurethral resection of the prostate

  • No prior cryosurgery

Other

  • No prior transurethral needle ablation of the prostate

  • No prior transurethral microwave thermotherapy of the prostate

Study Design

Total Participants: 588
Study Start date:
June 01, 2003
Estimated Completion Date:
December 22, 2022

Study Description

OBJECTIVES:

  • Compare the 5-year freedom from progression in patients with intermediate-risk prostate cancer treated with interstitial brachytherapy with or without external beam radiotherapy (EBRT).

  • Compare biochemical (i.e., prostate-specific antigen) failure, biochemical failure by the Phoenix definition, disease-specific survival, local progression, and distant metastases in patients treated with these regimens.

  • Compare morbidity and quality of life of patients treated with these regimens.

  • Determine the feasibility of collecting Medicare data in a large Radiation Therapy Oncology Group (RTOG) prostate cancer clinical trial for cost effectiveness and cost utility analysis of combined treatment with interstitial brachytherapy and EBRT.

  • Prospectively collect diagnostic biopsy samples from these patients for future biomarker analyses.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to disease stage (T1c vs T2a or T2b), Gleason score (≤ 6 vs 7), prostate-specific antigen (< 10 ng/mL vs 10-20 ng/mL), and prior neoadjuvant hormonal therapy (yes vs no). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients undergo external beam radiotherapy 5 days a week for 5 weeks. Within 2-4 weeks of radiotherapy, patients undergo interstitial brachytherapy with iodine I 125 or palladium Pd 103 seeds.

  • Arm II: Patients undergo interstitial brachytherapy only, as in arm I. Quality of life is assessed at baseline, at 4, 12, and 24 months, and then annually for 3 years.

After completion of study treatment, patients are followed at 3-5 weeks, at 4, 6, 9, and 12 months, every 6 months for 4 years, and then annually thereafter.

Connect with a study center

  • Cross Cancer Institute at University of Alberta

    Edmonton, Alberta T6G 1Z2
    Canada

    Site Not Available

  • British Columbia Cancer Agency - Centre for the Southern Interior

    Kelowna, British Columbia V1Y 5L3
    Canada

    Site Not Available

  • British Columbia Cancer Agency - Vancouver Cancer Centre

    Vancouver, British Columbia V5Z 4E6
    Canada

    Site Not Available

  • Princess Margaret Hospital

    Toronto, Ontario M5G 2M9
    Canada

    Site Not Available

  • Arizona Oncology Services Foundation

    Phoenix, Arizona 85013
    United States

    Site Not Available

  • Auburn Radiation Oncology

    Auburn, California 95603
    United States

    Site Not Available

  • Alta Bates Summit Comprehensive Cancer Center

    Berkeley, California 94704
    United States

    Site Not Available

  • Peninsula Medical Center

    Burlingame, California 94010
    United States

    Site Not Available

  • Radiation Oncology Centers - Cameron Park

    Cameron Park, California 95682
    United States

    Site Not Available

  • Mercy Cancer Center at Mercy San Juan Medical Center

    Carmichael, California 95608
    United States

    Site Not Available

  • East Bay Radiation Oncology Center

    Castro Valley, California 94546
    United States

    Site Not Available

  • Valley Medical Oncology Consultants - Castro Valley

    Castro Valley, California 94546
    United States

    Site Not Available

  • Valley Medical Oncology

    Fremont, California 94538
    United States

    Site Not Available

  • California Cancer Center - Woodward Park Office

    Fresno, California 93720
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Hayward

    Hayward, California 94545
    United States

    Site Not Available

  • Contra Costa Regional Medical Center

    Martinez, California 94553-3156
    United States

    Site Not Available

  • El Camino Hospital Cancer Center

    Mountain View, California 94040
    United States

    Site Not Available

  • Sutter Health - Western Division Cancer Research Group

    Novato, California 94945
    United States

    Site Not Available

  • Alta Bates Summit Medical Center - Summit Campus

    Oakland, California 94609
    United States

    Site Not Available

  • Bay Area Breast Surgeons, Incorporated

    Oakland, California 94609
    United States

    Site Not Available

  • CCOP - Bay Area Tumor Institute

    Oakland, California 94609
    United States

    Site Not Available

  • Kaiser Permanente - Division of Research - Oakland

    Oakland, California 94611
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Oakland

    Oakland, California 94611
    United States

    Site Not Available

  • Larry G Strieff MD Medical Corporation

    Oakland, California 94609
    United States

    Site Not Available

  • Tom K Lee, Incorporated

    Oakland, California 94609
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Rancho Cordova

    Rancho Cardova, California 95670
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Rancho Cordova

    Rancho Cordova, California 95670
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Redwood City

    Redwood City, California 94063
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Richmond

    Richmond, California 94801
    United States

    Site Not Available

  • Rohnert Park Cancer Center

    Rohnert Park, California 94928
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Roseville

    Roseville, California 95661
    United States

    Site Not Available

  • Radiation Oncology Center - Roseville

    Roseville, California 95661
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Sacramento

    Sacramento, California 95825
    United States

    Site Not Available

  • Mercy General Hospital

    Sacramento, California 95819
    United States

    Site Not Available

  • Radiological Associates of Sacramento Medical Group, Incorporated

    Sacramento, California 95815
    United States

    Site Not Available

  • South Sacramento Cancer Center

    Sacramento, California 95823
    United States

    Site Not Available

  • South Sacramento Kaiser-Permanente Medical Center

    Sacramento, California 95823
    United States

    Site Not Available

  • California Pacific Medical Center - California Campus

    San Francisco, California 94118
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - San Francisco Geary Campus

    San Francisco, California 94115
    United States

    Site Not Available

  • UCSF Helen Diller Family Comprehensive Cancer Center

    San Francisco, California 94115
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Santa Teresa

    San Jose, California 95119
    United States

    Site Not Available

  • Doctors Medical Center - San Pablo Campus

    San Pablo, California 94806
    United States

    Site Not Available

  • Kaiser Foundation Hospital - San Rafael

    San Rafael, California 94903
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Santa Clara Kiely Campus

    Santa Clara, California 95051
    United States

    Site Not Available

  • Santa Clara, California 95051
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Santa Rosa

    Santa Rosa, California 95403
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - South San Francisco

    South San Francisco, California 94080
    United States

    Site Not Available

  • Kaiser Permanente Medical Facility - Stockton

    Stockton, California 95210
    United States

    Site Not Available

  • Solano Radiation Oncology Center

    Vacaville, California 95687
    United States

    Site Not Available

  • Sutter Solano Medical Center

    Vallejo, California 94589
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Walnut Creek

    Walnut Creek, California 94596
    United States

    Site Not Available

  • St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center

    Grand Junction, Colorado 81502
    United States

    Site Not Available

  • Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

    Hartford, Connecticut 06105
    United States

    Site Not Available

  • Hospital of Saint Raphael

    New Haven, Connecticut 06511
    United States

    Site Not Available

  • CCOP - Christiana Care Health Services

    Newark, Delaware 19713
    United States

    Site Not Available

  • Sibley Memorial Hospital

    Washington, District of Columbia 20016
    United States

    Site Not Available

  • Sibley Memorial Hospital

    Washington, D.C., District of Columbia 20016
    United States

    Site Not Available

  • Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital

    Fort Lauderdale, Florida 33308
    United States

    Site Not Available

  • Mayo Clinic - Jacksonville

    Jacksonville, Florida 32224
    United States

    Site Not Available

  • Ella Milbank Foshay Cancer Center at Jupiter Medical Center

    Jupiter, Florida 33458
    United States

    Site Not Available

  • CCOP - Mount Sinai Medical Center

    Miami Beach, Florida 33140
    United States

    Site Not Available

  • Winship Cancer Institute of Emory University

    Altanta, Georgia 30322
    United States

    Site Not Available

  • Emory Crawford Long Hospital

    Atlanta, Georgia 30308
    United States

    Site Not Available

  • Northeast Georgia Medical Center

    Gainesville, Georgia 30501
    United States

    Site Not Available

  • Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

    Savannah, Georgia 31405
    United States

    Site Not Available

  • Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

    Boise, Idaho 83706
    United States

    Site Not Available

  • Resurrection Medical Center

    Chicago, Illinois 60631
    United States

    Site Not Available

  • Cancer Institute at St. John's Hospital

    Springfield, Illinois 62702
    United States

    Site Not Available

  • Regional Cancer Center at Memorial Medical Center

    Springfield, Illinois 62781-0001
    United States

    Site Not Available

  • Wendt Regional Cancer Center at Finley Hospital

    Dubuque, Iowa 52001
    United States

    Site Not Available

  • Menorah Medical Center

    Overland Park, Kansas 66209
    United States

    Site Not Available

  • CCOP - Kansas City

    Prairie Village, Kansas 66208
    United States

    Site Not Available

  • Lucille P. Markey Cancer Center at University of Kentucky

    Lexington, Kentucky 40536-0093
    United States

    Site Not Available

  • Greenebaum Cancer Center at University of Maryland Medical Center

    Baltimore, Maryland 21201
    United States

    Site Not Available

  • St. Agnes Hospital Cancer Center

    Baltimore, Maryland 21229
    United States

    Site Not Available

  • Central Maryland Oncology Center

    Columbia, Maryland 21044
    United States

    Site Not Available

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Cape Cod Hospital

    Hyannis, Massachusetts 02601
    United States

    Site Not Available

  • Shields Radiation Oncology Center - Mansfield

    Mansfield, Massachusetts 02048
    United States

    Site Not Available

  • South Suburban Oncology Center

    Quincy, Massachusetts 02169
    United States

    Site Not Available

  • Winchester Hospital Radiation Oncology Center

    Winchester, Massachusetts 01890
    United States

    Site Not Available

  • Hickman Cancer Center at Bixby Medical Center

    Adrian, Michigan 49221
    United States

    Site Not Available

  • CCOP - Michigan Cancer Research Consortium

    Ann Arbor, Michigan 48106
    United States

    Site Not Available

  • Saint Joseph Mercy Cancer Center

    Ann Arbor, Michigan 48106-0995
    United States

    Site Not Available

  • Oakwood Cancer Center at Oakwood Hospital and Medical Center

    Dearborn, Michigan 48123-2500
    United States

    Site Not Available

  • Genesys Hurley Cancer Institute

    Flint, Michigan 48503
    United States

    Site Not Available

  • Hurley Medical Center

    Flint, Michigan 48503
    United States

    Site Not Available

  • Van Elslander Cancer Center at St. John Hospital and Medical Center

    Grosse Pointe Woods, Michigan 48236
    United States

    Site Not Available

  • Foote Memorial Hospital

    Jackson, Michigan 49201
    United States

    Site Not Available

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • Haematology-Oncology Associates of Ohio and Michigan, PC

    Lambertville, Michigan 48144
    United States

    Site Not Available

  • Sparrow Regional Cancer Center

    Lansing, Michigan 48912-1811
    United States

    Site Not Available

  • St. Mary Mercy Hospital

    Livonia, Michigan 48154
    United States

    Site Not Available

  • St. Joseph Mercy Oakland

    Pontiac, Michigan 48341-2985
    United States

    Site Not Available

  • Mercy Regional Cancer Center at Mercy Hospital

    Port Huron, Michigan 48060
    United States

    Site Not Available

  • Seton Cancer Institute at Saint Mary's - Saginaw

    Saginaw, Michigan 48601
    United States

    Site Not Available

  • St. John Macomb Hospital

    Warren, Michigan 48093
    United States

    Site Not Available

  • Mayo Clinic Cancer Center

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • North Kansas City Hospital

    Kansas City, Missouri 64116
    United States

    Site Not Available

  • Parvin Radiation Oncology

    Kansas City, Missouri 64116
    United States

    Site Not Available

  • Research Medical Center

    Kansas City, Missouri 64132
    United States

    Site Not Available

  • Saint Luke's Cancer Institute at Saint Luke's Hospital

    Kansas City, Missouri 64111
    United States

    Site Not Available

  • St. Joseph Medical Center

    Kansas City, Missouri 64114
    United States

    Site Not Available

  • Liberty Hospital

    Liberty, Missouri 64068
    United States

    Site Not Available

  • Heartland Regional Medical Center

    Saint Joseph, Missouri 64506
    United States

    Site Not Available

  • Saint Joseph Oncology, Incorporated

    Saint Joseph, Missouri 64507
    United States

    Site Not Available

  • Barnes-Jewish West County Hospital

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

    Saint Louis, Missouri 63110
    United States

    Site Not Available

  • Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters

    Saint Peters, Missouri 63376
    United States

    Site Not Available

  • Good Samaritan Cancer Center at Good Samaritan Hospital

    Kearney, Nebraska 68848-1990
    United States

    Site Not Available

  • CCOP - Nevada Cancer Research Foundation

    Las Vegas, Nevada 89106
    United States

    Site Not Available

  • Nevada Cancer Institute

    Las Vegas, Nevada 89135
    United States

    Site Not Available

  • Renown Institute for Cancer at Renown Regional Medical Center

    Reno, Nevada 89502
    United States

    Site Not Available

  • Kingsbury Center for Cancer Care at Cheshire Medical Center

    Keene, New Hampshire 03431
    United States

    Site Not Available

  • Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire 03756-0002
    United States

    Site Not Available

  • Princeton Radiation Oncology Center

    Jamesburg, New Jersey 08831
    United States

    Site Not Available

  • Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton

    Marlton, New Jersey 08053
    United States

    Site Not Available

  • University Medical Center at Princeton

    Princeton, New Jersey 08540-3298
    United States

    Site Not Available

  • Fox Chase Virtua Health Cancer Program at Virtua West Jersey

    Voorhees, New Jersey 08043
    United States

    Site Not Available

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico 87131-5636
    United States

    Site Not Available

  • Cancer Institute of New Mexico

    Santa Fe, New Mexico 87505
    United States

    Site Not Available

  • New York Methodist Hospital

    Brooklyn, New York 11215
    United States

    Site Not Available

  • Roswell Park Cancer Institute

    Buffalo, New York 14263-0001
    United States

    Site Not Available

  • Sands Cancer Center

    Canandaigua, New York 14424
    United States

    Site Not Available

  • Sands Cancer Center

    Canandiaqua, New York 14424
    United States

    Site Not Available

  • Beth Israel Medical Center - Petrie Division

    New York, New York 10003-3803
    United States

    Site Not Available

  • Hudson Valley Oncology Associates

    Poughkeepsie, New York 12601
    United States

    Site Not Available

  • Highland Hospital of Rochester

    Rochester, New York 14620
    United States

    Site Not Available

  • James P. Wilmot Cancer Center at University of Rochester Medical Center

    Rochester, New York 14642
    United States

    Site Not Available

  • University Radiation Oncology at Parkridge Hospital

    Rochester, New York 14626
    United States

    Site Not Available

  • Blumenthal Cancer Center at Carolinas Medical Center

    Charlotte, North Carolina 28232-2861
    United States

    Site Not Available

  • Wayne Memorial Hospital, Incorporated

    Goldsboro, North Carolina 27534
    United States

    Site Not Available

  • Coleman Radiation Oncology Center at Carter General Hospital

    Morehead City, North Carolina 28557
    United States

    Site Not Available

  • CarolinaEast Cancer Care

    New Bern, North Carolina 28560
    United States

    Site Not Available

  • South Atlantic Radiation Oncology, LLC

    Supply, North Carolina 28462
    United States

    Site Not Available

  • Coastal Carolina Radiation Oncology Center

    Wilmington, North Carolina 28401
    United States

    Site Not Available

  • Summa Center for Cancer Care at Akron City Hospital

    Akron, Ohio 44309-2090
    United States

    Site Not Available

  • Radiation Oncology Center

    Alliance, Ohio 44601
    United States

    Site Not Available

  • Barberton Citizens Hospital

    Barberton, Ohio 44203
    United States

    Site Not Available

  • Adena Regional Medical Center

    Chillicothe, Ohio 45601
    United States

    Site Not Available

  • Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center

    Columbus, Ohio 43210-1240
    United States

    Site Not Available

  • CCOP - Columbus

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Doctors Hospital at Ohio Health

    Columbus, Ohio 43228
    United States

    Site Not Available

  • Grant Medical Center Cancer Care

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Mount Carmel Health - West Hospital

    Columbus, Ohio 43222
    United States

    Site Not Available

  • Riverside Methodist Hospital Cancer Care

    Columbus, Ohio 43214-3998
    United States

    Site Not Available

  • Grady Memorial Hospital

    Delaware, Ohio 43015
    United States

    Site Not Available

  • Community Cancer Center

    Elyria, Ohio 44035
    United States

    Site Not Available

  • Hematology Oncology Center

    Elyria, Ohio 44035
    United States

    Site Not Available

  • Lima Memorial Hospital

    Lima, Ohio 45804
    United States

    Site Not Available

  • Strecker Cancer Center at Marietta Memorial Hospital

    Marietta, Ohio 45750
    United States

    Site Not Available

  • Northwest Ohio Oncology Center

    Maumee, Ohio 43537-1839
    United States

    Site Not Available

  • Licking Memorial Cancer Care Program at Licking Memorial Hospital

    Newark, Ohio 43055
    United States

    Site Not Available

  • St. Charles Mercy Hospital

    Oregon, Ohio 43616
    United States

    Site Not Available

  • Cancer Care Center, Incorporated

    Salem, Ohio 44460
    United States

    Site Not Available

  • North Coast Cancer Care, Incorporated

    Sandusky, Ohio 44870
    United States

    Site Not Available

  • Community Hospital of Springfield and Clark County

    Springfield, Ohio 45505
    United States

    Site Not Available

  • Flower Hospital Cancer Center

    Sylvania, Ohio 43560
    United States

    Site Not Available

  • Mercy Hospital of Tiffin

    Tiffin, Ohio 44883
    United States

    Site Not Available

  • CCOP - Toledo Community Hospital

    Toledo, Ohio 43617
    United States

    Site Not Available

  • Medical University of Ohio Cancer Center

    Toledo, Ohio 43614
    United States

    Site Not Available

  • St. Anne Mercy Hospital

    Toledo, Ohio 43623
    United States

    Site Not Available

  • St. Vincent Mercy Medical Center

    Toledo, Ohio 43608
    United States

    Site Not Available

  • Toledo Clinic, Incorporated - Main Clinic

    Toledo, Ohio 43623
    United States

    Site Not Available

  • Toledo Hospital

    Toledo, Ohio 43606
    United States

    Site Not Available

  • Mount Carmel St. Ann's Cancer Center

    Westerville, Ohio 43081
    United States

    Site Not Available

  • Cancer Treatment Center

    Wooster, Ohio 44691
    United States

    Site Not Available

  • Genesis - Good Samaritan Hospital

    Zanesville, Ohio 43701
    United States

    Site Not Available

  • Oklahoma University Cancer Institute

    Oklahoma City, Oklahoma 73104
    United States

    Site Not Available

  • Geisinger Cancer Institute at Geisinger Health

    Danville, Pennsylvania 17822-0001
    United States

    Site Not Available

  • Mercy Fitzgerald Hospital

    Darby, Pennsylvania 19023
    United States

    Site Not Available

  • Northeast Radiation Oncology Center

    Dunmore, Pennsylvania 18512
    United States

    Site Not Available

  • Fox Chase Cancer Center Buckingham

    Furlong, Pennsylvania 18925
    United States

    Site Not Available

  • Fox Chase Cancer Center - Philadelphia

    Philadelphia, Pennsylvania 19111-2497
    United States

    Site Not Available

  • McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

    Reading, Pennsylvania 19612-6052
    United States

    Site Not Available

  • Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

    Wilkes-Barre, Pennsylvania 18711
    United States

    Site Not Available

  • York Cancer Center at Apple Hill Medical Center

    York, Pennsylvania 17405
    United States

    Site Not Available

  • M. D. Anderson Cancer Center at University of Texas

    Houston, Texas 77030-4009
    United States

    Site Not Available

  • Sandra L. Maxwell Cancer Center

    Cedar City, Utah 84720
    United States

    Site Not Available

  • Logan Regional Hospital

    Logan, Utah 84321
    United States

    Site Not Available

  • Jon and Karen Huntsman Cancer Center at Intermountain Medical Center

    Murray, Utah 84157
    United States

    Site Not Available

  • Val and Ann Browning Cancer Center at McKay-Dee Hospital Center

    Ogden, Utah 84403
    United States

    Site Not Available

  • Utah Valley Regional Medical Center - Provo

    Provo, Utah 84604
    United States

    Site Not Available

  • Dixie Regional Medical Center - East Campus

    Saint George, Utah 84770
    United States

    Site Not Available

  • LDS Hospital

    Salt Lake City, Utah 84143
    United States

    Site Not Available

  • Utah Cancer Specialists at UCS Cancer Center

    Salt Lake City, Utah 84106
    United States

    Site Not Available

  • Norris Cotton Cancer Center - North

    Saint Johnsbury, Vermont 05819
    United States

    Site Not Available

  • Fredericksburg Oncology, Incorporated

    Fredericksburg, Virginia 22401
    United States

    Site Not Available

  • Naval Medical Center - Portsmouth

    Portsmouth, Virginia 23708-2197
    United States

    Site Not Available

  • Veterans Affairs Medical Center - Richmond

    Richmond, Virginia 23249
    United States

    Site Not Available

  • St. Francis Hospital

    Federal Way, Washington 98003
    United States

    Site Not Available

  • Good Samaritan Cancer Center

    Puyallup, Washington 98372
    United States

    Site Not Available

  • CCOP - Northwest

    Tacoma, Washington 98405
    United States

    Site Not Available

  • Franciscan Cancer Center at St. Joseph Medical Center

    Tacoma, Washington 98405-3004
    United States

    Site Not Available

  • MultiCare Regional Cancer Center at Tacoma General Hospital

    Tacoma, Washington 98405
    United States

    Site Not Available

  • Franciscan Skemp Healthcare - La Crosse Campus

    La Crosse, Wisconsin 54601
    United States

    Site Not Available

  • Marshfield Clinic - Marshfield Center

    Marshfield, Wisconsin 54449
    United States

    Site Not Available

  • Columbia Saint Mary's Hospital - Ozaukee

    Mequon, Wisconsin 53097
    United States

    Site Not Available

  • Columbia-Saint Mary's Cancer Care Center

    Milwaukee, Wisconsin 53211
    United States

    Site Not Available

  • Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center

    Milwaukee, Wisconsin 53215
    United States

    Site Not Available

  • All Saints Cancer Center at Wheaton Franciscan Healthcare

    Racine, Wisconsin 53405
    United States

    Site Not Available

  • West Allis Memorial Hospital

    West Allis, Wisconsin 53227
    United States

    Site Not Available

  • Diagnostic and Treatment Center

    Weston, Wisconsin 54476
    United States

    Site Not Available

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