Risedronate in Preventing Bone Loss in Premenopausal Women Receiving Chemotherapy for Primary Breast Cancer

Last updated: July 12, 2016
Sponsor: Alliance for Clinical Trials in Oncology
Overall Status: Completed

Phase

3

Condition

Osteoporosis

Cancer

Breast Cancer

Treatment

N/A

Clinical Study ID

NCT00054418
NCCTG-N02C1
NCI-2012-02515
CDR0000270449
  • Ages > 18
  • Female

Study Summary

RATIONALE: Preventing bone loss in patients who are receiving chemotherapy for breast cancer may decrease the risk of fractures and may help patients live more comfortably. It is not yet known whether calcium is more effective with or without risedronate in preventing bone loss.

PURPOSE: This randomized phase III trial is studying two forms of calcium with or without risedronate to compare how well they work in preventing bone loss in premenopausal women who are receiving chemotherapy for primary stage I, stage II, stage IIIA, or stage IIIB breast cancer.

Eligibility Criteria

Inclusion

  1. Required Characteristics

  2. Premenopausal women

  • ≤ 6 months since last menstrual period

  • no prior bilateral oophorectomy

  • not on estrogen replacement therapy

  • if TAH is performed, with at least one intact ovary, or if > 3 months since last menstrual period, then patients must have premenopausal estrogen levels ≤ 1 month of study entry

  1. Scheduled to undergo adjuvant or neoadjuvant chemotherapy for primary breast cancer (stages I-IIIB)

  2. ≥ 18 years of age

  3. ECOG performance status (PS) 0 or 1

  4. Contraindications

  5. Hypercalcemia (calcium level > 1mg/dL above UNL ≤ 6 months

  6. Hypocalcemia (calcium level > 0.5 mg/dL below UNL ≤ 6 months

  7. Inability to stand or sit upright for at least 30 minutes

  8. Known swallowing disorder

  9. Bone mineral density T score of ≤ - 2.0 at the hip or lumbar spine

  • a patient with a T score of - 2.1 is ineligible

  • a patient with a T score of - 1.9 is eligible

  1. History of vertebral compression fracture
  • Exception: traumatic fracture of the coccyx would not exclude a patient from participation

  1. Corticosteroids at doses > 5 mg daily of prednison or equivalent for > 2 weeks in the past 6 months

  2. Previous treatment with bisphosphonates

  3. Diseases affecting bone metabolism (hyperthyroidism, hyperparathyroidism, and hypercortisolism)

  4. History of severe renal impairment or creatinine > 2.0 mg/dL

  5. Malabsorption syndrome

  6. Estrogen replacement therapy

  7. Oral contraceptive use

  8. Prior bilateral oophorectomy

  9. Pregnant women

  • Nursing women

  • Women of childbearing potential who are unwilling to employ adequate contraception (condoms, diaphragm, injections, intrauterine device [IUD], surgical sterilization, abstinence, etc.)

  • This study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown

  1. Dental extraction, root canal, or implants ≤ 3 months prior to registration or planned during study treatment

Study Design

Total Participants: 216
Study Start date:
March 01, 2003
Estimated Completion Date:
May 31, 2008

Study Description

OUTLINE: This is a randomized, placebo-controlled, double-blind study. Patients are stratified according to planned tamoxifen therapy (yes vs no vs undecided), planned taxane therapy (yes vs no vs undecided), time from last menses (1-3 months vs longer than 3 months to 6 months), and age (under 40 vs 40 to 49 vs 50 and over). Patients are randomized to 1 of 2 treatment arms. In both arms, treatment begins during the first month of chemotherapy and continues for 1 year in the absence of unacceptable toxicity. For more information regarding the treatment arms, please see the "Arms" section below. Questionnaires about cessation of menses, ovarian failure, and menopausal symptoms are completed at baseline, monthly during chemotherapy, at 6 months, and then at 1 and 2 years.

Patients are followed for 1 year. A summary of study goals is listed below.

Goals:

  1. To evaluate the effectiveness of risedronate at a weekly oral dose of 35 mg versus placebo in the prevention of bone loss in premenopausal women undergoing adjuvant or neoadjuvant chemotherapy for primary breast cancer.

  2. To evaluate the degree of bone loss over one year in premenopausal women undergoing adjuvant chemotherapy for primary breast cancer according to menopausal status at one year after therapy begins.

  3. To evaluate the relationship of current climacteric symptoms, menstrual and reproductive history, and chemotherapy regimen with ovarian failure (permanent cessation of menses) in premenopausal women undergoing adjuvant or neoadjuvant chemotherapy for primary breast cancer.

  4. To evaluate the relationship of baseline serum estradiol levels with ovarian failure in premenopausal women undergoing adjuvant or neoadjuvant chemotherapy for primary breast cancer.

Connect with a study center

  • Allan Blair Cancer Centre at Pasqua Hospital

    Regina, Saskatchewan S4T 7T1
    Canada

    Site Not Available

  • Mobile Infirmary Medical Center

    Mobile, Alabama 36652-2144
    United States

    Site Not Available

  • Mayo Clinic Scottsdale

    Scottsdale, Arizona 85259
    United States

    Site Not Available

  • Aurora Presbyterian Hospital

    Aurora, Colorado 80012
    United States

    Site Not Available

  • Boulder Community Hospital

    Boulder, Colorado 80301-9019
    United States

    Site Not Available

  • Penrose Cancer Center at Penrose Hospital

    Colorado Springs, Colorado 80933
    United States

    Site Not Available

  • CCOP - Colorado Cancer Research Program, Incorporated

    Denver, Colorado 80224-2522
    United States

    Site Not Available

  • Porter Adventist Hospital

    Denver, Colorado 80210
    United States

    Site Not Available

  • Presbyterian - St. Luke's Medical Center

    Denver, Colorado 80218
    United States

    Site Not Available

  • Rose Medical Center

    Denver, Colorado 80220
    United States

    Site Not Available

  • St. Joseph Hospital

    Denver, Colorado 80218
    United States

    Site Not Available

  • Swedish Medical Center

    Englewood, Colorado 80110
    United States

    Site Not Available

  • Sky Ridge Medical Center

    Lone Tree, Colorado 80124
    United States

    Site Not Available

  • Hope Cancer Care Center at Longmont United Hospital

    Longmont, Colorado 80502
    United States

    Site Not Available

  • St. Mary-Corwin Regional Medical Center

    Pueblo, Colorado 81004
    United States

    Site Not Available

  • North Suburban Medical Center

    Thorton, Colorado 80229
    United States

    Site Not Available

  • Gainesville, Florida 32605
    United States

    Site Not Available

  • Mayo Clinic - Jacksonville

    Jacksonville, Florida 32224
    United States

    Site Not Available

  • CCOP - Atlanta Regional

    Atlanta, Georgia 30342
    United States

    Site Not Available

  • Northside Hospital Cancer Center

    Atlanta, Georgia 30342-1611
    United States

    Site Not Available

  • Piedmont Hospital

    Atlanta, Georgia 30309
    United States

    Site Not Available

  • Saint Joseph's Hospital of Atlanta

    Atlanta, Georgia 30342-1701
    United States

    Site Not Available

  • MBCCOP-Medical College of Georgia Cancer Center

    Augusta, Georgia 30912
    United States

    Site Not Available

  • WellStar Cobb Hospital

    Austell, Georgia 30106
    United States

    Site Not Available

  • Charles B. Eberhart Cancer Center at DeKalb Medical Center

    Decatur, Georgia 30033
    United States

    Site Not Available

  • Gwinnett Medical Center

    Lawrenceville, Georgia 30045
    United States

    Site Not Available

  • Kennestone Cancer Center at Wellstar Kennestone Hospital

    Marietta, Georgia 30060
    United States

    Site Not Available

  • Southern Regional Medical Center

    Riverdale, Georgia 30274-2600
    United States

    Site Not Available

  • Rush-Copley Cancer Care Center

    Aurora, Illinois 60507
    United States

    Site Not Available

  • St. Joseph Medical Center

    Bloomington, Illinois 61701
    United States

    Site Not Available

  • Graham Hospital

    Canton, Illinois 61520
    United States

    Site Not Available

  • Memorial Hospital

    Carthage, Illinois 62321
    United States

    Site Not Available

  • Eureka Community Hospital

    Eureka, Illinois 61530
    United States

    Site Not Available

  • Galesburg Clinic

    Galesburg, Illinois 61401
    United States

    Site Not Available

  • Galesburg Cottage Hospital

    Galesburg, Illinois 61401
    United States

    Site Not Available

  • InterCommunity Cancer Center of Western Illinois

    Galesburg, Illinois 61401
    United States

    Site Not Available

  • Mason District Hospital

    Havana, Illinois 62644
    United States

    Site Not Available

  • Hopedale Medical Complex

    Hopedale, Illinois 61747
    United States

    Site Not Available

  • Joliet Oncology Hematology Associates, Limited - West

    Joliet, Illinois 60435
    United States

    Site Not Available

  • Kewanee Hospital

    Kewanee, Illinois 61443
    United States

    Site Not Available

  • McDonough District Hospital

    Macomb, Illinois 61455
    United States

    Site Not Available

  • Trinity Medical Center - East

    Moline, Illinois 61265
    United States

    Site Not Available

  • Moline, Illinois 61265
    United States

    Site Not Available

  • BroMenn Regional Medical Center

    Normal, Illinois 61761
    United States

    Site Not Available

  • Community Cancer Center

    Normal, Illinois 61761
    United States

    Site Not Available

  • Community Hospital of Ottawa

    Ottawa, Illinois 61350
    United States

    Site Not Available

  • Oncology Hematology Associates of Central Illinois - Ottawa

    Ottawa, Illinois 61350
    United States

    Site Not Available

  • Cancer Treatment Center at Pekin Hospital

    Pekin, Illinois 61554
    United States

    Site Not Available

  • CCOP - Illinois Oncology Research Association

    Peoria, Illinois 61615
    United States

    Site Not Available

  • Methodist Medical Center of Illinois

    Peoria, Illinois 61636
    United States

    Site Not Available

  • OSF St. Francis Medical Center

    Peoria, Illinois 61637
    United States

    Site Not Available

  • Oncology/Hematology Associates of Central Illinois, P.C.

    Peoria, Illinois 61615
    United States

    Site Not Available

  • Proctor Hospital

    Peoria, Illinois 61614
    United States

    Site Not Available

  • Illinois Valley Community Hospital

    Peru, Illinois 61354
    United States

    Site Not Available

  • Perry Memorial Hospital

    Princeton, Illinois 61356
    United States

    Site Not Available

  • St. Margaret's Hospital

    Spring Valley, Illinois 61362
    United States

    Site Not Available

  • Valley Cancer Center

    Spring Valley, Illinois 61362
    United States

    Site Not Available

  • CCOP - Carle Cancer Center

    Urbana, Illinois 61801
    United States

    Site Not Available

  • Carle Cancer Center at Carle Foundation Hospital

    Urbana, Illinois 61801
    United States

    Site Not Available

  • Saint Anthony Memorial Health Centers

    Michigan City, Indiana 46360
    United States

    Site Not Available

  • McFarland Clinic, P. C.

    Ames, Iowa 50010
    United States

    Site Not Available

  • Bettendorf, Iowa 52722
    United States

    Site Not Available

  • Saint Anthony Regional Hospital

    Carroll, Iowa 51401
    United States

    Site Not Available

  • Cedar Rapids Oncology Associates

    Cedar Rapids, Iowa 52403
    United States

    Site Not Available

  • Mercy Regional Cancer Center at Mercy Medical Center

    Cedar Rapids, Iowa 52403
    United States

    Site Not Available

  • St. Luke's Hospital

    Cedar Rapids, Iowa 52402
    United States

    Site Not Available

  • Alegent Health Mercy Hospital

    Council Bluffs, Iowa 51503
    United States

    Site Not Available

  • CCOP - Iowa Oncology Research Association

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • John Stoddard Cancer Center at Iowa Lutheran Hospital

    Des Moines, Iowa 50316-2301
    United States

    Site Not Available

  • John Stoddard Cancer Center at Iowa Methodist Medical Center

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • Medical Oncology and Hematology Associates at John Stoddard Cancer Center

    Des Moines, Iowa 50309
    United States

    Site Not Available

  • Medical Oncology and Hematology Associates at Mercy Cancer Center

    Des Moines, Iowa 50314
    United States

    Site Not Available

  • Mercy Cancer Center at Mercy Medical Center - Des Moines

    Des Moines, Iowa 50314
    United States

    Site Not Available

  • Mercy Capitol Hospital

    Des Moines, Iowa 50307
    United States

    Site Not Available

  • Alegent Health Community Memorial Hospital

    Missouri Valley, Iowa 51555-1199
    United States

    Site Not Available

  • Burgess Health Center

    Onawa, Iowa 51040
    United States

    Site Not Available

  • Ottumwa Regional Health Center Cancer Center

    Ottumwa, Iowa 52501
    United States

    Site Not Available

  • Mercy Medical Center - Sioux City

    Sioux City, Iowa 51104
    United States

    Site Not Available

  • Siouxland Hematology-Oncology Associates at June E. Nylen Cancer Center

    Sioux City, Iowa 51101
    United States

    Site Not Available

  • Siouxland Regional Cancer Center

    Sioux City, Iowa 51101
    United States

    Site Not Available

  • St. Luke's Regional Medical Center

    Sioux City, Iowa 51104
    United States

    Site Not Available

  • Medical Oncology and Hematology Associates - West Des Moines

    West Des Moines, Iowa 50266
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - Chanute

    Chanute, Kansas 66720
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - Dodge City

    Dodge City, Kansas 67801
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - El Dorado

    El Dorado, Kansas 67042
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - Kingman

    Kingman, Kansas 67068
    United States

    Site Not Available

  • Southwest Medical Center

    Liberal, Kansas 67901
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - Newton

    Newton, Kansas 67114
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - Parsons

    Parsons, Kansas 67357
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - Pratt

    Pratt, Kansas 67124
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - Salina

    Salina, Kansas 67042
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - Wellington

    Wellington, Kansas 67152
    United States

    Site Not Available

  • Associates in Womens Health, P.A. - North Review

    Wichita, Kansas 67203
    United States

    Site Not Available

  • CCOP - Wichita

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - Medical Arts Tower

    Wichita, Kansas 67208
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - Wichita

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Via Christi Cancer Center at Via Christi Regional Medical Center

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Cancer Center of Kansas, P.A. - Winfield

    Winfield, Kansas 67156
    United States

    Site Not Available

  • Ochsner Clinic of Baton Rouge

    Baton Rouge, Louisiana 708169990
    United States

    Site Not Available

  • Terrebonne General Medical Center

    Houma, Louisiana 70360
    United States

    Site Not Available

  • CCOP - Ochsner

    New Orleans, Louisiana 70121
    United States

    Site Not Available

  • Ochsner Cancer Institute at Ochsner Clinic Foundation

    New Orleans, Louisiana 70121
    United States

    Site Not Available

  • Hickman Cancer Center at Bixby Medical Center

    Adrian, Michigan 49221
    United States

    Site Not Available

  • CCOP - Michigan Cancer Research Consortium

    Ann Arbor, Michigan 48106
    United States

    Site Not Available

  • St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital

    Ann Arbor, Michigan 48106-0995
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Escanaba

    Escanaba, Michigan 49431
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Iron Mountain

    Iron Mountain, Michigan 49801
    United States

    Site Not Available

  • Haematology-Oncology Associates of Ohio and Michigan, P.C.

    Lambertville, Michigan 48144
    United States

    Site Not Available

  • Community Cancer Center of Monroe

    Monroe, Michigan 48162
    United States

    Site Not Available

  • Mercy Memorial Hospital System

    Monroe, Michigan 48162
    United States

    Site Not Available

  • MeritCare Clinic - Bemidji

    Bemidji, Minnesota 56601
    United States

    Site Not Available

  • Fairview Ridges Hospital

    Burnsville, Minnesota 55337
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Mercy Hospital

    Coon Rapids, Minnesota 55433
    United States

    Site Not Available

  • CCOP - Duluth

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • Miller-Dwan Medical Center

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • St. Mary's - Duluth Clinic Cancer Center

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • Fairview Southdale Hospital

    Edina, Minnesota 55435
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Unity Hospital

    Fridley, Minnesota 55432
    United States

    Site Not Available

  • Immanuel St. Joseph's Clinic

    Mankato, Minnesota 56002
    United States

    Site Not Available

  • Virginia Piper Cancer Institute at Abbott-Northwestern Hospital

    Minneapolis, Minnesota 55407
    United States

    Site Not Available

  • Hubert H. Humphrey Cancer Center at North Memorial Medical Center

    Robbinsdale, Minnesota 55422-2900
    United States

    Site Not Available

  • Mayo Clinic Cancer Center

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • CCOP - Metro-Minnesota

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Park Nicollet Health Services

    St. Louis Park, Minnesota 55416
    United States

    Site Not Available

  • United Hospital

    St. Paul, Minnesota 55102
    United States

    Site Not Available

  • Ridgeview Medical Center

    Waconia, Minnesota 55387
    United States

    Site Not Available

  • Hattiesburg Clinic, P.A.

    Hattiesburg, Mississippi 39401
    United States

    Site Not Available

  • CCOP - Montana Cancer Consortium

    Billings, Montana 59101
    United States

    Site Not Available

  • Deaconess Billings Clinic - Downtown

    Billings, Montana 59107-7000
    United States

    Site Not Available

  • Deaconess Billings Clinic Cancer Center

    Billings, Montana 59107-5100
    United States

    Site Not Available

  • Hematology-Oncology Centers of the Northern Rockies - Billings

    Billings, Montana 59101
    United States

    Site Not Available

  • Northern Rockies Radiation Oncology Center

    Billings, Montana 59101
    United States

    Site Not Available

  • St. Vincent Healthcare

    Billings, Montana 59101
    United States

    Site Not Available

  • Bozeman Deaconess Hospital

    Bozeman, Montana 59715
    United States

    Site Not Available

  • Internal Medicine Associates of Bozeman

    Bozeman, Montana 59715
    United States

    Site Not Available

  • St. James Community Hospital

    Butte, Montana 59701
    United States

    Site Not Available

  • Great Falls Clinic

    Great Falls, Montana 59405
    United States

    Site Not Available

  • St. Peter's Hospital

    Helena, Montana 59601
    United States

    Site Not Available

  • Glacier Oncology, PLLC

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Kalispell Medical Oncology

    Kalispell, Montana 59901
    United States

    Site Not Available

  • Eastern Montana Cancer Center

    Miles City, Montana 59301
    United States

    Site Not Available

  • Community Medical Center

    Missoula, Montana 59801
    United States

    Site Not Available

  • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

    Missoula, Montana 59807
    United States

    Site Not Available

  • Montana Cancer Specialists at Montana Cancer Center

    Missoula, Montana 59807-7877
    United States

    Site Not Available

  • Bryan LGH Medical Center West

    Lincoln, Nebraska 68502
    United States

    Site Not Available

  • Cancer Resource Center - Lincoln

    Lincoln, Nebraska 68510
    United States

    Site Not Available

  • St. Elizabeth Regional Medical Center

    Lincoln, Nebraska 68510
    United States

    Site Not Available

  • Bergan Mercy Medical Center

    Omaha, Nebraska 68124
    United States

    Site Not Available

  • CCOP - Missouri Valley Cancer Consortium

    Omaha, Nebraska 68106
    United States

    Site Not Available

  • Creighton University Medical Center

    Omaha, Nebraska 68131-2197
    United States

    Site Not Available

  • Immanuel Medical Center

    Omaha, Nebraska 68122
    United States

    Site Not Available

  • Midlands Cancer Center at Midlands Community Hospital

    Papillion, Nebraska 68046-4194
    United States

    Site Not Available

  • Rutherford Hospital

    Rutherfordton, North Carolina 28139
    United States

    Site Not Available

  • Bismarck Cancer Center

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • Cancer Care Center at Medcenter One Hospital

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • Mid Dakota Clinic, P. C.

    Bismarck, North Dakota 58501
    United States

    Site Not Available

  • St. Alexius Medical Center

    Bismarck, North Dakota 58502
    United States

    Site Not Available

  • CCOP - MeritCare Hospital

    Fargo, North Dakota 58122
    United States

    Site Not Available

  • MeritCare Medical Group

    Fargo, North Dakota 58122
    United States

    Site Not Available

  • Altru Cancer Center at Altru Hospital

    Grand Forks, North Dakota 58201
    United States

    Site Not Available

  • Wood County Oncology Center

    Bowling Green, Ohio 43402
    United States

    Site Not Available

  • Blanchard Valley Medical Associates

    Findlay, Ohio 45840
    United States

    Site Not Available

  • Fremont Memorial Hospital

    Fremont, Ohio 43420
    United States

    Site Not Available

  • Kenton Oncology, Incorporated

    Kenton, Ohio 43326
    United States

    Site Not Available

  • Lima Memorial Hospital

    Lima, Ohio 45804
    United States

    Site Not Available

  • Northwest Ohio Oncology Center

    Maumee, Ohio 43537
    United States

    Site Not Available

  • St. Luke's Hospital

    Maumee, Ohio 43537
    United States

    Site Not Available

  • St. Charles Mercy Hospital

    Oregon, Ohio 43616
    United States

    Site Not Available

  • Toledo Clinic - Oregon

    Oregon, Ohio 43616
    United States

    Site Not Available

  • Firelands Regional Medical Center

    Sandusky, Ohio 44870
    United States

    Site Not Available

  • North Coast Cancer Care, Incorporated

    Sandusky, Ohio 44870
    United States

    Site Not Available

  • Promedica Cancer Center at Flower Hospital

    Sylvania, Ohio 43560
    United States

    Site Not Available

  • Mercy Hospital of Tiffin

    Tiffin, Ohio 44883
    United States

    Site Not Available

  • CCOP - Toledo Community Hospital

    Toledo, Ohio 43623
    United States

    Site Not Available

  • Medical College of Ohio Cancer Institute

    Toledo, Ohio 43614
    United States

    Site Not Available

  • St. Vincent Mercy Medical Center

    Toledo, Ohio 43608
    United States

    Site Not Available

  • Toledo Clinic, Incorporated - Main Clinic

    Toledo, Ohio 43623
    United States

    Site Not Available

  • Toledo Hospital

    Toledo, Ohio 43606
    United States

    Site Not Available

  • Toledo Surgical Specialists

    Toledo, Ohio 43623
    United States

    Site Not Available

  • Fulton County Health Center

    Wauseon, Ohio 43567
    United States

    Site Not Available

  • Natalie Warren Bryant Cancer Center at St. Francis Hospital

    Tulsa, Oklahoma 74136
    United States

    Site Not Available

  • Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest

    Allentown, Pennsylvania 18105
    United States

    Site Not Available

  • Geisinger Medical Center

    Danville, Pennsylvania 17822-0001
    United States

    Site Not Available

  • Geisinger Medical Group

    State College, Pennsylvania 16801
    United States

    Site Not Available

  • Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

    Wilkes-Barre, Pennsylvania 18711
    United States

    Site Not Available

  • Rose Ramer Cancer Clinic at Anderson Area Medical Center

    Anderson, South Carolina 29621
    United States

    Site Not Available

  • CCOP - Upstate Carolina

    Spartanburg, South Carolina 29303
    United States

    Site Not Available

  • Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

    Spartanburg, South Carolina 29303
    United States

    Site Not Available

  • Rapid City Regional Hospital

    Rapid City, South Dakota 57701
    United States

    Site Not Available

  • Avera McKennan Hospital and University Health Center

    Sioux Falls, South Dakota 57105-1080
    United States

    Site Not Available

  • Medical X-Ray Center, P. C.

    Sioux Falls, South Dakota 57105
    United States

    Site Not Available

  • Sioux Valley Hospital and University of South Dakota Medical Center

    Sioux Falls, South Dakota 57117-5039
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Mary's Hospital

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Vincent Hospital

    Green Bay, Wisconsin 54301-3526
    United States

    Site Not Available

  • St. Mary's Hospital Medical Center - Green Bay

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54307-3508
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Oconto Falls

    Oconto Falls, Wisconsin 54154
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Sturgeon Bay

    Sturgeon Bay, Wisconsin 54235
    United States

    Site Not Available

  • Welch Cancer Center at Sheridan Memorial Hospital

    Sheridan, Wyoming 82801
    United States

    Site Not Available

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