Radiation Therapy With or Without Optional Tamoxifen in Treating Women With Ductal Carcinoma in Situ

Last updated: May 23, 2022
Sponsor: Radiation Therapy Oncology Group
Overall Status: Completed

Phase

3

Condition

Genitourinary Cancer

Precancerous Condition

Carcinoma

Treatment

N/A

Clinical Study ID

NCT00003857
RTOG-9804
CALGB-49801
NCI-2011-02038
CDR0000067020
CAN-NCIC-MA26
  • Ages 26-120
  • Female

Study Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen by the tumor cells. It is not yet known if radiation therapy is more effective than observation, with or without tamoxifen, in treating ductal carcinoma in situ.

PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with that of observation, with or without tamoxifen, in treating women who have ductal carcinoma in situ.

Eligibility Criteria

Inclusion

DISEASE CHARACTERISTICS:

  • Ductal carcinoma in situ (DCIS) of the breast detected by mammogram at the time of diagnosis

  • Unicentric

  • Lesions ≤ 2.5 cm

  • Low nuclei grade (NG1) or intermediate nuclei grade (NG2) with necrosis in < one third of the involved ducts

  • Inked margins ≥ 3 mm

  • Clinically node negative

  • Non-palpable

  • No suspicious areas on post-operative mammogram taken within 12 weeks after final surgery

  • No bloody nipple discharge

  • No more than 12 weeks since prior final surgery (arm II only)

  • Hormone receptor status:

  • Not specified

PATIENT CHARACTERISTICS:

Age:

  • 26 and over

Sex:

  • Female

Menopausal status:

  • Not specified

Performance status:

  • Not specified

Life expectancy:

  • Not specified

Hematopoietic:

  • Not specified

Hepatic:

  • Not specified

Renal:

  • Not specified

Other:

  • Not pregnant or nursing

  • No active connective tissue disorders (e.g., lupus or scleroderma)

  • No prior malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • Not specified

Chemotherapy:

  • No prior chemotherapy

Endocrine therapy:

  • No other concurrent hormonal therapy (e.g., raloxifene, hormone replacement therapy, or birth control pills)

Radiotherapy:

  • No prior radiotherapy

Surgery:

  • See Disease Characteristics

Study Design

Total Participants: 636
Study Start date:
December 01, 1999
Estimated Completion Date:
May 20, 2022

Study Description

OBJECTIVES:

  • Compare the efficacy of whole breast radiotherapy vs observation with or without optional tamoxifen in decreasing or delaying the appearance of local failure (both invasive and in situ) and preventing the need for mastectomy in women with good-risk ductal carcinoma in situ (DCIS) of the breast.

  • Compare distant disease-free survival of patients treated with these regimens.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to age (under 50 vs 50 and over), final path margins (negative vs 3-9 mm vs at least 10 mm), mammographic size of primary (no greater than 1 cm vs greater than 1 cm to 2.5 cm), nuclei grade (low vs intermediate), and tamoxifen use (yes vs no). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients undergo observation and may receive optional oral tamoxifen once daily (at the discretion of the physician) for 5 years.

  • Arm II: Beginning within 12 weeks after final surgery, patients receive radiotherapy to the whole breast once daily, 5 days a week, for 3.5-5.5 weeks. Patients may receive optional tamoxifen as in arm I.

Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 1,790 patients will be accrued for this study within 6 years.

Connect with a study center

  • Cross Cancer Institute at University of Alberta

    Edmonton, Alberta T6G 1Z2
    Canada

    Site Not Available

  • Lethbridge Cancer Centre

    Lethbridge, Alberta T1J 1W5
    Canada

    Site Not Available

  • British Columbia Cancer Agency - Centre for the Southern Interior

    Kelowna, British Columbia V1Y 5L3
    Canada

    Site Not Available

  • Nanaimo Cancer Clinic at Nanaimo Regional General Hospital

    Nanaimo, British Columbia V9S 2B7
    Canada

    Site Not Available

  • Lions Gate Hospital

    North Vancouver, British Columbia V7L 2P9
    Canada

    Site Not Available

  • BCCA - Fraser Valley Cancer Centre

    Surrey, British Columbia V3V 1Z2
    Canada

    Site Not Available

  • British Columbia Cancer Agency - Vancouver Cancer Centre

    Vancouver, British Columbia V5Z 4E6
    Canada

    Site Not Available

  • Prostate Centre at Vancouver General Hospital

    Vancouver, British Columbia V5Z 3J5
    Canada

    Site Not Available

  • Providence Health Care - Vancouver

    Vancouver, British Columbia V6Z 1Y6
    Canada

    Site Not Available

  • British Columbia Cancer Agency - Vancouver Island Cancer Centre

    Victoria, British Columbia V8R 6V5
    Canada

    Site Not Available

  • G. Steinhoff Clinical Research

    Victoria, British Columbia V8V 3N1
    Canada

    Site Not Available

  • CancerCare Manitoba

    Winnipeg, Manitoba R3E 0V9
    Canada

    Site Not Available

  • Moncton Hospital

    Moncton, New Brunswick E1C 6ZB
    Canada

    Site Not Available

  • Saint John Regional Hospital

    Saint John, New Brunswick E2L 4L2
    Canada

    Site Not Available

  • Newfoundland Cancer Treatment and Research Foundation

    St. Johns, Newfoundland and Labrador A1B 3V6
    Canada

    Site Not Available

  • Nova Scotia Cancer Centre

    Halifax, Nova Scotia B3H 1V7
    Canada

    Site Not Available

  • Cape Breton Cancer Centre

    Sydney, Nova Scotia B1P 1P3
    Canada

    Site Not Available

  • Royal Victoria Hospital of Barrie

    Barrie, Ontario L4M 6M2
    Canada

    Site Not Available

  • William Osler Health Centre

    Brampton, Ontario L6W 2Z8
    Canada

    Site Not Available

  • Margaret and Charles Juravinski Cancer Centre

    Hamilton, Ontario L8V 5C2
    Canada

    Site Not Available

  • St. Joseph's Hospital

    Hamilton, Ontario L8N 4A6
    Canada

    Site Not Available

  • Cancer Centre of Southeastern Ontario at Kingston General Hospital

    Kingston, Ontario K7L 5P9
    Canada

    Site Not Available

  • Grand River Regional Cancer Centre at Grand River Hospital

    Kitchner, Ontario N2G 1G3
    Canada

    Site Not Available

  • London Regional Cancer Program at London Health Sciences Centre

    London, Ontario N6A 4L6
    Canada

    Site Not Available

  • Markham Stouffville Hospital

    Markham, Ontario L6B IAI
    Canada

    Site Not Available

  • Trillium Health Centre - Mississauga Site

    Mississauga, Ontario L5B 1B8
    Canada

    Site Not Available

  • Southlake Regional Health Centre

    Newmarket, Ontario L3Y 2P9
    Canada

    Site Not Available

  • North York General Hospital - Ontario

    North York, Ontario M2K 1E1
    Canada

    Site Not Available

  • Male Health Centre - Oakville

    Oakville, Ontario L6H 3PI
    Canada

    Site Not Available

  • R. S. McLaughlin Durham Regional Cancer Centre at Lakeridge Health Oshawa

    Oshawa, Ontario L1G 2B9
    Canada

    Site Not Available

  • Ottawa Hospital Regional Cancer Centre - General Campus

    Ottawa, Ontario K1H 8L6
    Canada

    Site Not Available

  • Peterborough Oncology Clinic

    Peterborough, Ontario K9H 7B6
    Canada

    Site Not Available

  • Algoma Regional Cancer Program at Sault Area Hospital

    Sault Sainte Marie, Ontario P6A 2C4
    Canada

    Site Not Available

  • Scarborough Hospital - General Campus

    Scarborough, Ontario M1P 2V5
    Canada

    Site Not Available

  • St. Catharines General Hospital at Niagara Health System

    St. Catharines, Ontario L2R 5K3
    Canada

    Site Not Available

  • Northeastern Ontario Regional Cancer Centre

    Sudbury, Ontario P3E 5J1
    Canada

    Site Not Available

  • Northwestern Ontario Regional Cancer Care at Thunder Bay Regional Health Sciences Centre

    Thunder Bay, Ontario P7B 6V4
    Canada

    Site Not Available

  • Male Health Centre - North York

    Toronto, Ontario M6A 3B5
    Canada

    Site Not Available

  • Mount Sinai Hospital - Toronto

    Toronto, Ontario M5G 1X5
    Canada

    Site Not Available

  • Princess Margaret Hospital

    Toronto, Ontario M5G 2M9
    Canada

    Site Not Available

  • St. Joseph's Health Centre - Toronto

    Toronto, Ontario M6R 1B5
    Canada

    Site Not Available

  • St. Michael's Hospital - Toronto

    Toronto, Ontario M5B 1W8
    Canada

    Site Not Available

  • Toronto East General Hospital

    Toronto, Ontario M4C 3E7
    Canada

    Site Not Available

  • Toronto Sunnybrook Regional Cancer Centre at Sunnybrook Health Sciences Centre

    Toronto, Ontario M4N 3M5
    Canada

    Site Not Available

  • Humber River Regional Hospital - Weston

    Weston, Ontario M9N 1N8
    Canada

    Site Not Available

  • Windsor Regional Cancer Centre at Windsor Regional Hospital

    Windsor, Ontario N8W 2X3
    Canada

    Site Not Available

  • Prince Edward Island Cancer Centre at Queen Elizabeth Hospital

    Charlottetown, Prince Edward Island C1A 8T5
    Canada

    Site Not Available

  • Centre de Sante et de Services Sociaux de Chicoutimi

    Chicoutimi, Quebec G7H 5H6
    Canada

    Site Not Available

  • CHUS-Hopital Fleurimont

    Fleurimont, Quebec J1H 5N4
    Canada

    Site Not Available

  • Doctor Leon Richard Oncology Centre

    Greenfield Park, Quebec J4V 2H1
    Canada

    Site Not Available

  • Hopital Charles Lemoyne

    Greenfield Park, Quebec J4V 2H1
    Canada

    Site Not Available

  • Centre Hospitalier Regional de Lanaudiere

    Joliette, Quebec J6E 6J2
    Canada

    Site Not Available

  • Hotel-Dieu de Levis

    Levis, Quebec G6V 3Z1
    Canada

    Site Not Available

  • Centre Hospitalier de l'Universite de Montreal

    Montreal, Quebec (P.Q.) H2X 3J4
    Canada

    Site Not Available

  • Hopital Du Sacre-Coeur de Montreal

    Montreal, Quebec H4J 1C5
    Canada

    Site Not Available

  • Hopital Sainte Justine

    Montreal, Quebec H3T 1C5
    Canada

    Site Not Available

  • Hotel Dieu de Montreal

    Montreal, Quebec H2W 1T8
    Canada

    Site Not Available

  • Maisonneuve-Rosemont Hospital

    Montreal, Quebec H1T 2M4
    Canada

    Site Not Available

  • Centre Hospitalier Universitaire de Quebec

    Quebec City, Quebec G1R 2J6
    Canada

    Site Not Available

  • Hopital du Saint-Sacrement - Quebec

    Quebec City, Quebec G1S 4L8
    Canada

    Site Not Available

  • L'Hopital Laval

    Ste-Foy, Quebec G1V 4G5
    Canada

    Site Not Available

  • Allan Blair Cancer Centre at Pasqua Hospital

    Regina, Saskatchewan S4T 7T1
    Canada

    Site Not Available

  • Saskatoon Cancer Centre at the University of Saskatchewan

    Saskatoon, Saskatchewan S7N 4H4
    Canada

    Site Not Available

  • Centre Hospitalier Regional de Rimouski

    Quebec, G1S 4L8
    Canada

    Site Not Available

  • Mobile Infirmary Medical Center

    Mobile, Alabama 36652-2144
    United States

    Site Not Available

  • Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital

    Fairbanks, Alaska 99701
    United States

    Site Not Available

  • Arizona Oncology Services Foundation

    Phoenix, Arizona 85013
    United States

    Site Not Available

  • Saint Joseph's Mercy Cancer Center

    Hot Springs, Arkansas 71913
    United States

    Site Not Available

  • Providence Saint Joseph Medical Center - Burbank

    Burbank, California 91505
    United States

    Site Not Available

  • Enloe Cancer Center at Enloe Medical Center

    Chico, California 95926
    United States

    Site Not Available

  • Mount Diablo Regional Cancer Center

    Concord, California 94524-4110
    United States

    Site Not Available

  • North Bay Cancer Center

    Fairfield, California 94533
    United States

    Site Not Available

  • Washington Township Hospital

    Fremont, California 94538
    United States

    Site Not Available

  • Saint Agnes Medical Center

    Fresno, California 93720-3397
    United States

    Site Not Available

  • Cancer Care Consultants Medical Associates at Daniel Freeman Memorial Hospital

    Inglewood, California 90301
    United States

    Site Not Available

  • USC/Norris Comprehensive Cancer Center and Hospital

    Los Angeles, California 90089-9181
    United States

    Site Not Available

  • Providence Holy Cross Cancer Center

    Mission Hills, California 91346-9600
    United States

    Site Not Available

  • Memorial Medical Center Cancer Services

    Modesto, California 95355
    United States

    Site Not Available

  • CCOP - Bay Area Tumor Institute

    Oakland, California 94609
    United States

    Site Not Available

  • Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center

    Pomona, California 91767
    United States

    Site Not Available

  • Radiological Associates of Sacramento Medical Group, Incorporated

    Sacramento, California 95815
    United States

    Site Not Available

  • University of California Davis Cancer Center

    Sacramento, California 95817
    United States

    Site Not Available

  • CCOP - Santa Rosa Memorial Hospital

    Sana Rosa, California 95405
    United States

    Site Not Available

  • CCOP - Santa Rosa Memorial Hospital

    Santa Rosa, California 95405
    United States

    Site Not Available

  • Torrance Memorial Medical Center

    Torrance, California 90509
    United States

    Site Not Available

  • John Muir/Mt. Diablo Comprehensive Cancer Center

    Walnut Creek, California 94598
    United States

    Site Not Available

  • Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital

    Whittier, California 90602
    United States

    Site Not Available

  • St. Vincent's Medical Center

    Bridgeport, Connecticut 06606
    United States

    Site Not Available

  • Hospital of Saint Raphael

    New Haven, Connecticut 06511
    United States

    Site Not Available

  • Eastern Connecticut Hematology and Oncology Associates

    Norwich, Connecticut 06360
    United States

    Site Not Available

  • CCOP - Christiana Care Health Services

    Newark, Delaware 19713
    United States

    Site Not Available

  • Lombardi Comprehensive Cancer Center at Georgetown University Medical Center

    Washington, District of Columbia 20007
    United States

    Site Not Available

  • Lombardi Comprehensive Cancer Center at Georgetown University Medical Center

    Washington, D.C., District of Columbia 20007
    United States

    Site Not Available

  • University of Florida Shands Cancer Center

    Gainesville, Florida 32610-0232
    United States

    Site Not Available

  • Mayo Clinic - Jacksonville

    Jacksonville, Florida 32224
    United States

    Site Not Available

  • Lakeland Regional Cancer Center at Lakeland Regional Medical Center

    Lakeland, Florida 33805
    United States

    Site Not Available

  • Baptist-South Miami Regional Cancer Program

    Miami, Florida 33176
    United States

    Site Not Available

  • University of Miami Sylvester Comprehensive Cancer Center

    Miami, Florida 33136
    United States

    Site Not Available

  • Northeast Georgia Medical Center

    Gainesville, Georgia 30501
    United States

    Site Not Available

  • Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

    Savannah, Georgia 31405
    United States

    Site Not Available

  • Leeward Radiation Oncology Center

    'Ewa Beach, Hawaii 96706
    United States

    Site Not Available

  • Leeward Radiation Oncology Center

    Ewa Beach, Hawaii 96706
    United States

    Site Not Available

  • Cancer Research Center of Hawaii

    Honolula, Hawaii 96813
    United States

    Site Not Available

  • Cancer Research Center of Hawaii

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Queen's Cancer Institute at Queen's Medical Center

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • St. Francis Medical Center

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • Tripler Army Medical Center

    Honolulu, Hawaii 96859
    United States

    Site Not Available

  • St. Luke's Mountain States Tumor Institute - Boise

    Boise, Idaho 83712
    United States

    Site Not Available

  • Hematology Oncology Associates of Eastern Idaho

    Idaho Falls, Idaho 83404
    United States

    Site Not Available

  • Northwest Community Hospital

    Arlington Heights, Illinois 60005
    United States

    Site Not Available

  • Rush-Copley Cancer Care Center

    Aurora, Illinois 60507
    United States

    Site Not Available

  • Good Shepherd Hospital

    Barrington, Illinois 60010
    United States

    Site Not Available

  • St. Joseph Medical Center

    Bloomington, Illinois 61701
    United States

    Site Not Available

  • Creticos Cancer Center at Advocate Illinois Masonic Medical Center

    Chicago, Illinois 60657
    United States

    Site Not Available

  • John H. Stroger, Jr. Hospital of Cook County

    Chicago, Illinois 60612-3785
    United States

    Site Not Available

  • Robert H. Lurie Comprehensive Cancer Center at Northwestern University

    Chicago, Illinois 60611-3013
    United States

    Site Not Available

  • Advocate Good Samaritan Hospital

    Downers Grove, Illinois 60515
    United States

    Site Not Available

  • InterCommunity Cancer Center of Western Illinois

    Galesburg, Illinois 61401
    United States

    Site Not Available

  • Joliet Oncology-Hematology Associates, Limited - West

    Joliet, Illinois 60435
    United States

    Site Not Available

  • Cardinal Bernardin Cancer Center at Loyola University Medical Center

    Maywood, Illinois 60153
    United States

    Site Not Available

  • BroMenn Regional Medical Center

    Normal, Illinois 61761
    United States

    Site Not Available

  • Community Cancer Center

    Normal, Illinois 61761
    United States

    Site Not Available

  • Lutheran General Cancer Care Center

    Park Ridge, Illinois 60068
    United States

    Site Not Available

  • Cancer Treatment Center at Pekin Hospital

    Pekin, Illinois 61554
    United States

    Site Not Available

  • CCOP - Illinois Oncology Research Association

    Peoria, Illinois 61615
    United States

    Site Not Available

  • Methodist Medical Center of Illinois

    Peoria, Illinois 61636
    United States

    Site Not Available

  • OSF St. Francis Medical Center

    Peoria, Illinois 61637
    United States

    Site Not Available

  • Oncology Hematology Associates of Central Illinois, PC - Peoria

    Peoria, Illinois 61615
    United States

    Site Not Available

  • Valley Cancer Center

    Spring Valley, Illinois 61362
    United States

    Site Not Available

  • CCOP - Carle Cancer Center

    Urbana, Illinois 61801
    United States

    Site Not Available

  • Carle Cancer Center at Carle Foundation Hospital

    Urbana, Illinois 61801
    United States

    Site Not Available

  • St. John's Cancer Center at St. John's Medical Center

    Anderson, Indiana 46016
    United States

    Site Not Available

  • Regional Cancer Institute at Bloomington Hospital

    Bloomington, Indiana 47403
    United States

    Site Not Available

  • Elkhart General Hospital

    Elkhart, Indiana 46515
    United States

    Site Not Available

  • Parkview Regional Cancer Center at Parkview Health

    Fort Wayne, Indiana 46805
    United States

    Site Not Available

  • Indiana University Cancer Center

    Indianapolis, Indiana 46202-5289
    United States

    Site Not Available

  • Howard Community Hospital at Howard Regional Health System

    Kokomo, Indiana 46904
    United States

    Site Not Available

  • Center for Cancer Therapy at LaPorte Hospital and Health Services

    La Porte, Indiana 46350
    United States

    Site Not Available

  • Saint Anthony Memorial Health Centers

    Michigan City, Indiana 46360
    United States

    Site Not Available

  • CCOP - Northern Indiana CR Consortium

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Memorial Hospital of South Bend

    South Bend, Indiana 46601
    United States

    Site Not Available

  • Cedar Rapids Oncology Associates

    Cedar Rapids, Iowa 52403
    United States

    Site Not Available

  • Mercy Regional Cancer Center at Mercy Medical Center

    Cedar Rapids, Iowa 52403
    United States

    Site Not Available

  • St. Luke's Hospital

    Cedar Rapids, Iowa 52402
    United States

    Site Not Available

  • St. Francis Comprehensive Cancer Center

    Topeka, Kansas 66606
    United States

    Site Not Available

  • Stormont-Vail Cancer Center

    Topeka, Kansas 66604
    United States

    Site Not Available

  • Cancer Treatment Center for Southern Kentucky

    Bowling Green, Kentucky 42101
    United States

    Site Not Available

  • Central Baptist Hospital

    Lexington, Kentucky 40503-9985
    United States

    Site Not Available

  • Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County

    Madisonville, Kentucky 42431
    United States

    Site Not Available

  • Central Maine Medical Center

    Lewiston, Maine 04240
    United States

    Site Not Available

  • Maine Medical Center - Bramhall Campus

    Portland, Maine 04102
    United States

    Site Not Available

  • DeCesaris Cancer Institute at Anne Arundel Medical Center

    Annapolis, Maryland 21401
    United States

    Site Not Available

  • Greater Baltimore Medical Center

    Baltimore, Maryland 21204
    United States

    Site Not Available

  • Suburban Hospital

    Bethesda, Maryland 20814
    United States

    Site Not Available

  • Peninsula Regional Medical Center

    Salisbury, Maryland 21801
    United States

    Site Not Available

  • Brigham and Women's Hospital

    Boston, Massachusetts 02115
    United States

    Site Not Available

  • Cancer Research Center at Boston Medical Center

    Boston, Massachusetts 02118
    United States

    Site Not Available

  • Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute

    Boston, Massachusetts 02115
    United States

    Site Not Available

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts 02114
    United States

    Site Not Available

  • Lahey Clinic Medical Center - Burlington

    Burlington, Massachusetts 01805
    United States

    Site Not Available

  • Bethke Cancer Center at Emerson Hospital

    Concord, Massachusetts 01742
    United States

    Site Not Available

  • Hudner Oncology Center at Saint Anne's Hospital

    Fall River, Massachusetts 02721
    United States

    Site Not Available

  • MetroWest Medical Center - Framingham Union Hospital

    Framingham, Massachusetts 01702
    United States

    Site Not Available

  • Cape Cod Hospital

    Hyannis, Massachusetts 02601
    United States

    Site Not Available

  • Lowell General Hospital

    Lowell, Massachusetts 01854
    United States

    Site Not Available

  • Community Cancer Care at Milford Regional Medical Center

    Milford, Massachusetts 01757
    United States

    Site Not Available

  • Caritas Norwood Hospital

    Norwood, Massachusetts 02062
    United States

    Site Not Available

  • Baystate Regional Cancer Program at D'Amour Center for Cancer Care

    Springfield, Massachusetts 01199
    United States

    Site Not Available

  • Hickman Cancer Center at Bixby Medical Center

    Adrian, Michigan 49221
    United States

    Site Not Available

  • CCOP - Michigan Cancer Research Consortium

    Ann Arbor, Michigan 48106
    United States

    Site Not Available

  • St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital

    Ann Arbor, Michigan 48106-0995
    United States

    Site Not Available

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan 48109-0942
    United States

    Site Not Available

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan 48201-1379
    United States

    Site Not Available

  • Josephine Ford Cancer Center at Henry Ford Hospital

    Detroit, Michigan 48202
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Escanaba

    Escanaba, Michigan 49431
    United States

    Site Not Available

  • Genesys Hurley Cancer Institute

    Flint, Michigan 48503
    United States

    Site Not Available

  • Great Lakes Cancer Institute at McLaren Regional Medical Center

    Flint, Michigan 48532
    United States

    Site Not Available

  • CCOP - Grand Rapids

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Lacks Cancer Center at Saint Mary's Mercy Medical Center

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Spectrum Health Cancer Care - Butterworth Campus

    Grand Rapids, Michigan 49503
    United States

    Site Not Available

  • Van Elslander Cancer Center at St. John Hospital and Medical Center

    Grosse Pointe Woods, Michigan 48236
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Iron Mountain

    Iron Mountain, Michigan 49801
    United States

    Site Not Available

  • Foote Hospital

    Jackson, Michigan 49201
    United States

    Site Not Available

  • Borgess Medical Center

    Kalamazoo, Michigan 49001
    United States

    Site Not Available

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007-3731
    United States

    Site Not Available

  • Borgess Medical Center

    Kalamazooaa, Michigan 49001
    United States

    Site Not Available

  • Breslin Cancer Center at Ingham Regional Medical Center

    Lansing, Michigan 48910
    United States

    Site Not Available

  • Upper Michigan Cancer Center at Marquette General Hospital

    Marquette, Michigan 49855
    United States

    Site Not Available

  • MidMichigan Medical Center - Midland

    Midland, Michigan 48670
    United States

    Site Not Available

  • Northern Michigan Hospital

    Petoskey, Michigan 49770
    United States

    Site Not Available

  • William Beaumont Hospital - Royal Oak Campus

    Royal Oak, Michigan 48073
    United States

    Site Not Available

  • Seton Cancer Institute - Saginaw

    Saginaw, Michigan 48601
    United States

    Site Not Available

  • Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph

    Saint Joseph, Michigan 49085
    United States

    Site Not Available

  • Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph

    St. Joseph, Michigan 49085
    United States

    Site Not Available

  • Munson Medical Center

    Traverse City, Michigan 49684
    United States

    Site Not Available

  • St. John Macomb Hospital

    Warren, Michigan 48093
    United States

    Site Not Available

  • Fairview Ridges Hospital

    Burnsville, Minnesota 55337
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Mercy Hospital

    Coon Rapids, Minnesota 55433
    United States

    Site Not Available

  • St. Mary's - Duluth Clinic Cancer Center

    Duluth, Minnesota 55805
    United States

    Site Not Available

  • Fairview Southdale Hospital

    Edina, Minnesota 55435
    United States

    Site Not Available

  • Mercy and Unity Cancer Center at Unity Hospital

    Fridley, Minnesota 55432
    United States

    Site Not Available

  • Immanuel St. Joseph's Clinic

    Mankato, Minnesota 56002
    United States

    Site Not Available

  • Virginia Piper Cancer Institute at Abbott-Northwestern Hospital

    Minneapolis, Minnesota 55407
    United States

    Site Not Available

  • Hubert H. Humphrey Cancer Center at North Memorial Medical Center

    Robbinsdale, Minnesota 55422-2900
    United States

    Site Not Available

  • Mayo Clinic Cancer Center

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • CentraCare Clinic - River Campus

    Saint Cloud, Minnesota 56303
    United States

    Site Not Available

  • Coborn Cancer Center

    Saint Cloud, Minnesota 56303
    United States

    Site Not Available

  • CCOP - Metro-Minnesota

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Park Nicollet Health Services

    Saint Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Regions Hospital Cancer Care Center

    Saint Paul, Minnesota 55101
    United States

    Site Not Available

  • United Hospital

    Saint Paul, Minnesota 55102
    United States

    Site Not Available

  • CentraCare Clinic - River Campus

    St. Cloud, Minnesota 56303
    United States

    Site Not Available

  • Park Nicollet Health Services

    St. Louis Park, Minnesota 55416
    United States

    Site Not Available

  • Regions Hospital Cancer Care Center

    St. Paul, Minnesota 55101
    United States

    Site Not Available

  • Ridgeview Medical Center

    Waconia, Minnesota 55387
    United States

    Site Not Available

  • University of Mississippi Medical Center

    Jackson, Mississippi 39216
    United States

    Site Not Available

  • Ellis Fischel Cancer Center at University of Missouri - Columbia

    Columbia, Missouri 65203
    United States

    Site Not Available

  • CCOP - Kansas City

    Kansas City, Missouri 64131
    United States

    Site Not Available

  • CCOP - Montana Cancer Consortium

    Billings, Montana 59101
    United States

    Site Not Available

  • Deaconess Billings Clinic - Downtown

    Billings, Montana 59107-7000
    United States

    Site Not Available

  • Northern Rockies Radiation Oncology Center

    Billings, Montana 59101
    United States

    Site Not Available

  • Great Falls Clinic

    Great Falls, Montana 59405
    United States

    Site Not Available

  • Good Samaritan Cancer Center at Good Samaritan Hospital

    Kearney, Nebraska 68848-1990
    United States

    Site Not Available

  • Methodist Cancer Center at Methodist Hospital - Omaha

    Omaha, Nebraska 68114
    United States

    Site Not Available

  • CCOP - Nevada Cancer Research Foundation

    Las Vegas, Nevada 89106
    United States

    Site Not Available

  • Dartmouth - Hitchcock Concord

    Concord, New Hampshire 03301
    United States

    Site Not Available

  • Seacoast Cancer Center at Wentworth-Douglass Hospital

    Dover, New Hampshire 03820
    United States

    Site Not Available

  • Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire 03756-0002
    United States

    Site Not Available

  • Elliot Regional Cancer Center at Elliot Hospital

    Manchester, New Hampshire 03103
    United States

    Site Not Available

  • Veterans Affairs Medical Center - East Orange

    East Orange, New Jersey 07018-1095
    United States

    Site Not Available

  • John F. Kennedy Medical Center

    Edison, New Jersey 08818
    United States

    Site Not Available

  • Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center

    Englewood, New Jersey 07631
    United States

    Site Not Available

  • Monmouth Medical Center

    Long Branch, New Jersey 07740-6395
    United States

    Site Not Available

  • Fox Chase Virtua Health Cancer Program - Marlton

    Marlton, New Jersey 08053
    United States

    Site Not Available

  • Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School

    New Brunswick, New Jersey 08903
    United States

    Site Not Available

  • Saint Peter's University Hospital

    New Brunswick, New Jersey 08903
    United States

    Site Not Available

  • Newark Beth Israel Medical Center

    Newark, New Jersey 07112
    United States

    Site Not Available

  • AtlantiCare Regional Medical Center

    Pomona, New Jersey 08240
    United States

    Site Not Available

  • Booker Cancer Center at Riverview Medical Center

    Red Bank, New Jersey 07701
    United States

    Site Not Available

  • Fox Chase Cancer Center at St. Francis Medical Center

    Trenton, New Jersey 08629
    United States

    Site Not Available

  • Cancer Institute of New Jersey at Cooper - Voorhees

    Voorhees, New Jersey 08043
    United States

    Site Not Available

  • Albuquerque Regional Medical Center at Lovelace Sandia Health System

    Albuquerque, New Mexico 87102
    United States

    Site Not Available

  • University of New Mexico Cancer Research and Treatment Center

    Albuquerque, New Mexico 87131-5636
    United States

    Site Not Available

  • Long Island College Hospital

    Brooklyn, New York 11201
    United States

    Site Not Available

  • Roswell Park Cancer Institute

    Buffalo, New York 14263-0001
    United States

    Site Not Available

  • CCOP - North Shore University Hospital

    Manhasset, New York 11030
    United States

    Site Not Available

  • North Shore University Hospital

    Manhasset, New York 11030
    United States

    Site Not Available

  • Tucker Center for Cancer Care at Orange Regional Medical Center

    Middletown, New York 10940-4199
    United States

    Site Not Available

  • Long Island Jewish Medical Center

    New Hyde Park, New York 11042
    United States

    Site Not Available

  • Memorial Sloan-Kettering Cancer Center

    New York, New York 10021
    United States

    Site Not Available

  • CCOP - Hematology-Oncology Associates of Central New York

    Syracuse, New York 13057
    United States

    Site Not Available

  • Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

    Chapel Hill, North Carolina 27599-7295
    United States

    Site Not Available

  • Blumenthal Cancer Center at Carolinas Medical Center

    Charlotte, North Carolina 28232-2861
    United States

    Site Not Available

  • Batte Cancer Center at Northeast Medical Center

    Concord, North Carolina 28025
    United States

    Site Not Available

  • Duke Comprehensive Cancer Center

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Wayne Memorial Hospital, Incorporated

    Goldsboro, North Carolina 27534
    United States

    Site Not Available

  • Wayne Radiation Oncology

    Goldsboro, North Carolina 27534
    United States

    Site Not Available

  • Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital

    Greenville, North Carolina 27835-6028
    United States

    Site Not Available

  • Pardee Memorial Hospital

    Hendersonville, North Carolina 28791
    United States

    Site Not Available

  • Lenoir Memorial Cancer Center

    Kinston, North Carolina 28501
    United States

    Site Not Available

  • Moore Regional Community Hospital Comprehensive Cancer Center

    Pinehurst, North Carolina 28374
    United States

    Site Not Available

  • Rex Cancer Center at Rex Hospital

    Raleigh, North Carolina 27607
    United States

    Site Not Available

  • Rutherford Hospital

    Rutherfordton, North Carolina 28139
    United States

    Site Not Available

  • Zimmer Cancer Center at New Hanover Regional Medical Center

    Wilmington, North Carolina 28401
    United States

    Site Not Available

  • Wilmed Radiation Oncology Services

    Wilson, North Carolina 27893
    United States

    Site Not Available

  • Trinity Cancer Care Center

    Minot, North Dakota 58701
    United States

    Site Not Available

  • McDowell Cancer Center at Akron General Medical Center

    Akron, Ohio 44307
    United States

    Site Not Available

  • Mercy Cancer Center at Mercy Medical Center

    Canton, Ohio 44708
    United States

    Site Not Available

  • Adena Regional Medical Center

    Chillicothe, Ohio 45601
    United States

    Site Not Available

  • Bethesda North Hospital

    Cincinnati, Ohio 45242
    United States

    Site Not Available

  • Cancer Treatment Center at Good Samaritan Hospital

    Cincinnati, Ohio 45220
    United States

    Site Not Available

  • Case Comprehensive Cancer Center

    Cleveland, Ohio 44106
    United States

    Site Not Available

  • Cleveland Clinic Taussig Cancer Center

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • MetroHealth's Cancer Care Center at MetroHealth Medical Center

    Cleveland, Ohio 44109
    United States

    Site Not Available

  • Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University

    Columbus, Ohio 43210-1240
    United States

    Site Not Available

  • CCOP - Columbus

    Columbus, Ohio 43215
    United States

    Site Not Available

  • Mount Carmel Health - West Hospital

    Columbus, Ohio 43222
    United States

    Site Not Available

  • Riverside Methodist Hospital Cancer Care

    Columbus, Ohio 43214-3998
    United States

    Site Not Available

  • Grady Memorial Hospital

    Delaware, Ohio 43015
    United States

    Site Not Available

  • Blanchard Valley Medical Associates

    Findlay, Ohio 45840
    United States

    Site Not Available

  • Lima Memorial Hospital

    Lima, Ohio 45804
    United States

    Site Not Available

  • St. Rita's Medical Center

    Lima, Ohio 45801
    United States

    Site Not Available

  • Strecker Cancer Center at Marietta Memorial Hospital

    Marietta, Ohio 45750
    United States

    Site Not Available

  • Northwest Ohio Oncology Center

    Maumee, Ohio 43623
    United States

    Site Not Available

  • Hillcrest Cancer Center at Hillcrest Hospital

    Mayfield Heights, Ohio 44124
    United States

    Site Not Available

  • Licking Memorial Cancer Care Program at Licking Memorial Hospital

    Newark, Ohio 43055
    United States

    Site Not Available

  • St. Charles Mercy Hospital

    Oregon, Ohio 43616
    United States

    Site Not Available

  • Firelands Regional Medical Center

    Sandusky, Ohio 44870
    United States

    Site Not Available

  • Mercy Medical Center

    Springfield, Ohio 45504
    United States

    Site Not Available

  • Promedica Cancer Center at Flower Hospital

    Sylvania, Ohio 43560
    United States

    Site Not Available

  • CCOP - Toledo Community Hospital

    Toledo, Ohio 43623
    United States

    Site Not Available

  • Medical University of Ohio Cancer Center

    Toledo, Ohio 43614
    United States

    Site Not Available

  • St. Vincent Mercy Medical Center

    Toledo, Ohio 43608
    United States

    Site Not Available

  • Toledo Clinic, Incorporated - Main Clinic

    Toledo, Ohio 43623
    United States

    Site Not Available

  • St. Joseph Cancer Center at St. Joseph Health Center

    Warren, Ohio 44484
    United States

    Site Not Available

  • Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital

    Westerville, Ohio 43081
    United States

    Site Not Available

  • Natalie Warren Bryant Cancer Center at St. Francis Hospital

    Tulsa, Oklahoma 74136
    United States

    Site Not Available

  • Three Rivers Community Hospital

    Grants Pass, Oregon 97527
    United States

    Site Not Available

  • Legacy Mount Hood Medical Center

    Gresham, Oregon 97030
    United States

    Site Not Available

  • Dubs Cancer Center at Rogue Valley Medical Center

    Medford, Oregon 97504
    United States

    Site Not Available

  • Providence Medford Medical Center

    Medford, Oregon 97504
    United States

    Site Not Available

  • Providence Milwaukie Hospital

    Milwaukie, Oregon 97222
    United States

    Site Not Available

  • CCOP - Columbia River Oncology Program

    Portland, Oregon 97225
    United States

    Site Not Available

  • Cancer Institute at Oregon Health and Science University

    Portland, Oregon 97239-3098
    United States

    Site Not Available

  • Legacy Emanuel Hospital and Health Center & Children's Hospital

    Portland, Oregon 97227
    United States

    Site Not Available

  • Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center

    Portland, Oregon 97210
    United States

    Site Not Available

  • Providence Cancer Center at Providence Portland Medical Center

    Portland, Oregon 97213-2967
    United States

    Site Not Available

  • Providence St. Vincent Medical Center

    Portland, Oregon 97225
    United States

    Site Not Available

  • Legacy Meridian Park Hospital

    Tualatin, Oregon 97062
    United States

    Site Not Available

  • Rosenfeld Cancer Center at Abington Memorial Hospital

    Abington, Pennsylvania 19001
    United States

    Site Not Available

  • St. Luke's Hospital Cancer Center

    Bethlehem, Pennsylvania 18015
    United States

    Site Not Available

  • Bryn Mawr Hospital

    Bryn Mawr, Pennsylvania 19010
    United States

    Site Not Available

  • Geisinger Medical Center

    Danville, Pennsylvania 17822-0001
    United States

    Site Not Available

  • Mercy Fitzgerald Hospital

    Darby, Pennsylvania 19023
    United States

    Site Not Available

  • Easton Regional Cancer Center at Easton Hospital

    Easton, Pennsylvania 18042
    United States

    Site Not Available

  • St. Mary Regional Cancer Center

    Langhorne, Pennsylvania 19047
    United States

    Site Not Available

  • Paoli Memorial Hospital

    Paoli, Pennsylvania 19301-1792
    United States

    Site Not Available

  • Fox Chase-Temple Cancer Center CCOP Research Base

    Philadelphia, Pennsylvania 19140
    United States

    Site Not Available

  • Kimmel Cancer Center at Thomas Jefferson University - Philadelphia

    Philadelphia, Pennsylvania 19107-5541
    United States

    Site Not Available

  • Hillman Cancer Center at University of Pittsburgh Cancer Institute

    Pittsburgh, Pennsylvania 15232
    United States

    Site Not Available

  • Mercy Cancer Institute at Mercy Hospital

    Pittsburgh, Pennsylvania 15219
    United States

    Site Not Available

  • Reading Hospital and Medical Center

    Reading, Pennsylvania 19612-6052
    United States

    Site Not Available

  • Mercy Hospital Cancer Center - Scranton

    Scranton, Pennsylvania 18501
    United States

    Site Not Available

  • Mount Nittany Medical Center

    State College, Pennsylvania 16803
    United States

    Site Not Available

  • Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

    Wilkes-Barre, Pennsylvania 18711
    United States

    Site Not Available

  • CCOP - MainLine Health

    Wynnewood, Pennsylvania 19096
    United States

    Site Not Available

  • Lankenau Cancer Center at Lankenau Hospital

    Wynnewood, Pennsylvania 19096
    United States

    Site Not Available

  • York Cancer Center at Wellspan Health

    York, Pennsylvania 17403
    United States

    Site Not Available

  • AnMed Health Cancer Center

    Anderson, South Carolina 29621
    United States

    Site Not Available

  • Palmetto Health South Carolina Cancer Center

    Columbia, South Carolina 29203
    United States

    Site Not Available

  • Bon Secours St. Francis Health System

    Greenville, South Carolina 29601
    United States

    Site Not Available

  • CCOP - Greenville

    Greenville, South Carolina 29615
    United States

    Site Not Available

  • CCOP - Upstate Carolina

    Spartanburg, South Carolina 29303
    United States

    Site Not Available

  • Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

    Spartanburg, South Carolina 29303
    United States

    Site Not Available

  • Rapid City Regional Hospital

    Rapid City, South Dakota 57701
    United States

    Site Not Available

  • Medical X-Ray Center, PC

    Sioux Falls, South Dakota 57105
    United States

    Site Not Available

  • Sioux Valley Hospital and University of South Dakota Medical Center

    Sioux Falls, South Dakota 57117-5039
    United States

    Site Not Available

  • University of Texas Medical Branch

    Galveston, Texas 77555-0209
    United States

    Site Not Available

  • M.D. Anderson Cancer Center at University of Texas

    Houston, Texas 77030-4009
    United States

    Site Not Available

  • Doctor's Hospital of Laredo

    Laredo, Texas 78041
    United States

    Site Not Available

  • Joe Arrington Cancer Research and Treatment Center

    Lubbock, Texas 79410-1894
    United States

    Site Not Available

  • Cottonwood Hospital Medical Center

    Murray, Utah 84107
    United States

    Site Not Available

  • McKay-Dee Hospital Center

    Ogden, Utah 84403
    United States

    Site Not Available

  • Utah Valley Regional Medical Center - Provo

    Provo, Utah 84604
    United States

    Site Not Available

  • Dixie Regional Medical Center - East Campus

    Saint George, Utah 84770
    United States

    Site Not Available

  • LDS Hospital

    Salt Lake City, Utah 84143
    United States

    Site Not Available

  • Utah Cancer Specialists at UCS Cancer Center

    Salt Lake City, Utah 84106
    United States

    Site Not Available

  • Fletcher Allen Health Care - University Health Center Campus

    Burlington, Vermont 05401
    United States

    Site Not Available

  • Community Cancer Center at Rutland Regional Medical Center

    Rutland, Vermont 05701
    United States

    Site Not Available

  • Martha Jefferson Hospital Cancer Care Center

    Charlottesville, Virginia 22901
    United States

    Site Not Available

  • Naval Medical Center - Portsmouth

    Portsmouth, Virginia 23708-2197
    United States

    Site Not Available

  • St. Francis Hospital

    Federal Way, Washington 98003
    United States

    Site Not Available

  • Cascade Cancer Center at Evergreen Hospital Medical Center

    Kirkland, Washington 98033
    United States

    Site Not Available

  • CCOP - Virginia Mason Research Center

    Seattle, Washington 98101
    United States

    Site Not Available

  • Group Health Central Hospital

    Seattle, Washington 98112
    United States

    Site Not Available

  • Swedish Cancer Institute at Swedish Medical Center - First Hill Campus

    Seattle, Washington 98122-4307
    United States

    Site Not Available

  • University Cancer Center at University of Washington Medical Center

    Seattle, Washington 98195-6043
    United States

    Site Not Available

  • Cancer Care Northwest - Spokane South

    Spokane, Washington 99202
    United States

    Site Not Available

  • Madigan Army Medical Center - Tacoma

    Tacoma, Washington 98431
    United States

    Site Not Available

  • Southwest Washington Medical Center Cancer Center

    Vancouver, Washington 98668
    United States

    Site Not Available

  • Theda Care Cancer Institute

    Appleton, Wisconsin 54911
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Mary's Hospital

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • Green Bay Oncology, Limited at St. Vincent Hospital

    Green Bay, Wisconsin 54301-3526
    United States

    Site Not Available

  • St. Mary's Hospital Medical Center - Green Bay

    Green Bay, Wisconsin 54303
    United States

    Site Not Available

  • St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54307-3508
    United States

    Site Not Available

  • Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center

    Green Bay, Wisconsin 54311
    United States

    Site Not Available

  • Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center

    La Crosse, Wisconsin 54601
    United States

    Site Not Available

  • University of Wisconsin Comprehensive Cancer Center

    Madison, Wisconsin 53792-6164
    United States

    Site Not Available

  • Bay Area Cancer Care Center at Bay Area Medical Center

    Marinette, Wisconsin 54143
    United States

    Site Not Available

  • Community Memorial Hospital Cancer Care Center

    Menomonee Falls, Wisconsin 53051
    United States

    Site Not Available

  • Columbia St. Mary's Cancer Care Center

    Milwaukee, Wisconsin 53211
    United States

    Site Not Available

  • Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center

    Milwaukee, Wisconsin 53215
    United States

    Site Not Available

  • Regional Cancer Center at Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin 53066
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Oconto Falls

    Oconto Falls, Wisconsin 54154
    United States

    Site Not Available

  • Green Bay Oncology, Limited - Sturgeon Bay

    Sturgeon Bay, Wisconsin 54235
    United States

    Site Not Available

  • Waukesha Memorial Hospital Regional Cancer Center

    Waukesha, Wisconsin 53188
    United States

    Site Not Available

  • West Allis Memorial Hospital

    West Milwaukee, Wisconsin 53227
    United States

    Site Not Available

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