A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With Reduced Kidney Function

Inclusion Criteria:

• Male or female of nonchildbearing potential, between the ages of 18 and 80 years, atthe screening visit.

• BMI of 17.5 to 40.0 kg/m2 (inclusive), and a total body weight ≥45 kg (99 lbs).

• Stable renal function, defined as ≤25% difference between 2 measurements of eGFR.

• Group 1 only: at screening, no clinically relevant abnormalities identified by adetailed medical history, physical exam, including blood pressure and pulse ratemeasurement, ECG and clinical laboratory tests.

• Group 1 only: normal renal function (mean eGFR ≥90 mL/min) based on an average ofmeasures from the screening visits.

• Groups 2 & 3 only: good general health considered acceptable with the expectedhealth status of individuals with chronic renal impairment.

• Groups 2 & 3 only: chronic renal impairment, defined by the following mean eGFRcriteria (based on screening visits):

• Severe RI: 15 ≤ mean eGFR <30 mL/min, not requiring hemodialysis.

• Moderate RI: 30 ≤ mean eGFR <60 mL/min.

Exclusion Criteria:

• Any condition possibly affecting drug absorption.

• At screening, a positive result for HIV antibodies.

• History of renal, liver, or heart transplantation.

• Urinary incontinence without catheterization.

• Evidence of a prothrombotic state, including history of deep vein thrombosis,pulmonary embolism, or arterial thrombosis, or known genetic predisposition.

• Use of an investigational product within 30 days or 5 half-lives (whichever longer).

• A positive urine drug test or breath alcohol test at screening or admission to studyclinic.

• Group 1 only: evidence or history of clinically significant hematological, renal,endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric,neurological, or allergic disease.

• Group 1 only: screening ECG demonstrating QTcF interval >450 ms or a QRS interval >120 ms.

• Group 1 only: screening seated systolic blood pressure ≥140 mm Hg or diastolic bloodpressure ≥90 mm Hg

• Group 2 & 3 only: presence of acute renal disease

• Group 2 & 3 only: requiring dialysis or anticipated need for dialysis

• Group 2 & 3 only: listed for solid organ transplantation

• Groups 2 & 3 only: persistent severe, uncontrolled hypertension at screening,admission to study clinic, or pre-dose on Day 1.

• Groups 2 & 3 only: screening ECG demonstrating a QTcF interval >470 ms or a QRSinterval >120 ms.

• Groups 2 & 3 only: unstable medical conditions or comorbidities that would interferewith study participation