Phase
Condition
Glaucoma
Eye Disease
Retina
Treatment
OCT
Clinical Study ID
Ages > 22 All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion/Exclusion Criteria Inclusion Criteria for Retinal Disease Group
Participants 22 years of age or older on the date of informed consent
Participants able to understand the written informed consent and willing to participate as evidenced by signing the informed consent
BCVA 20/400 or better in the study eye
Participants presenting at the site with retinal disease
Diagnosis of some type of retinal pathology by investigator, may include, but not limited to: Macular Degeneration (including participants with drusen and geographic atrophy and choroidal neovascularization), Diabetic Macular Edema, Diabetic Retinopathy, Macular Hole, Epiretinal Membrane, Central Serous Retinopathy and others
Exclusion Criteria for Retinal Disease Group
Participants unable to tolerate ophthalmic imaging
Participants not able to obtain acceptable OCT images due to ocular media opacity or other reasons
Participant has a condition or is in a situation which the investigator feels may put the participant at significant risk, may confound the study results, or may interfere significantly with the participant's participation in the study
Presence of glaucoma or any ocular pathology other than a retinal pathology in the study eye as determined by self-report and/or investigator assessment at the study visit;
Inclusion Criteria for Glaucoma Group
Participants 22 years of age or older on the date of informed consent
Participants able to understand the written informed consent and willing to participate as evidenced by signing the informed consent
BCVA 20/40 or better in the study eye
History of Visual field defects within the previous year from the study visit or measured the day of the study visit consistent with glaucomatous optic nerve damage with at least one of the following two findings:
On pattern deviation (PD), there exists a cluster of 3 or more points in an expected location of the visual field depressed below the 5% level, at least 1 of which is depressed below the 1% level;
Glaucoma hemi-field test "outside normal limits."
Glaucomatous optic nerve damage as evidenced by any of the following optic disc or retinal nerve fiber layer structural abnormalities:
Diffuse thinning, focal narrowing, or notching of the neuroretinal rim, especially at the inferior or superior poles with or without disc hemorrhage;
Optic disc neural rim asymmetry of the two eyes consistent with loss of neural tissue
Exclusion Criteria for Glaucoma Group
Participants unable to tolerate ophthalmic imaging
Participants not able to obtain acceptable OCT images due to ocular media opacity or other reasons
Participant has a condition or is in a situation which the investigator feels may put the participant at significant risk, may confound the study results, or may interfere significantly with the participant's participation in the study
No reliable visual field test result within the previous year from the study visit, defined as fixation losses > 33% or false positives > 33%, or false negatives > 33% in the study eye
Presence of any ocular pathology except glaucoma in the study eye Inclusion Criteria for Corneal Group
Participants 22 years of age or older on the date of informed consent 2. Participants able to understand the written informed consent and willing to participate as evidenced by signing the informed consent 3. Participants presenting at the site with corneal disease, for example but not limited to, corneal disorders due to contact lens wear, post-refractive surgery, dry eye, keratoconus 4. Participant is able to comply with the study procedures.
Exclusion Criteria for Corneal Group
Participants unable to tolerate ophthalmic imaging
Participant has a condition or is in a situation which the investigator feels may put the participant at significant risk, may confound the study results, or may interfere significantly with the participant's participation in the study
Participant with ocular media not sufficiently clear to obtain acceptable OCT images.
Inclusion Criteria for Normal Group
Participants 22 years of age or older on the date of informed consent
Participants able to understand the written informed consent and willing to participate as evidenced by signing the informed consent
Participants presenting at the site with normal eyes (Cataracts, LASIK, PRK, and peripheral pathology that does not affect the posterior pole region, for example lattice and peripheral drusen, are allowed).
BCVA 20/40 or better (each eye)
Participant is able to comply with the study procedures
Exclusion Criteria for Normal Group
Participants unable to tolerate ophthalmic imaging
Participant has a condition or is in a situation which the investigator feels may put the participant at significant risk, may confound the study results, or may interfere significantly with the participant's participation in the study
Participant with ocular media not sufficiently clear to obtain acceptable OCT images
History of leukemia, dementia or multiple sclerosis
Study Design
Connect with a study center
Ketchum Health
Anaheim 5323810, California 5332921 92807
United StatesActive - Recruiting
Eye Disease Consultants, LLC
West Hartford 4845411, Connecticut 4831725 06107
United StatesActive - Recruiting
Eye Care and Laser Surgery of Newton Wellselley
Wellesley Hills 4954749, Massachusetts 6254926 02481
United StatesCompleted
Charles Retina Institute
Germantown 4624601, Tennessee 4662168 38138
United StatesActive - Recruiting

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