Evaluation of Efficacy and Safety of AR882 and XOI Co-administration in Uricase Treatment Failed Patients

Inclusion Criteria:

• History of uncontrolled gout

• Presence of ≥1 clinically visible tophus

• Last uricase infusion occurred ≥3 months

• Body weight no less than 50 kg

• Serum creatinine must be < 3.0 mg/dL and estimated CLcr ≥ 40 mL/min

Exclusion Criteria:

• Malignancy within 5 years, except for successfully treated basal or squamous cellcarcinoma of the skin

• Pregnant or breastfeeding

• History of symptomatic kidney stones within the past 6 months

• Received pegloticase, rasburicase or other experimental uricases within the last 3months