Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Severe Active GPA or MPA

Key inclusion criteria:

1. Men and women, aged ≥18 and ≤ 75 years with a diagnosis of GPA or MPA according tothe American College of Rheumatology/ European League Against Rheumatism 2022 (ACR/EULAR 2022) classification criteria

2. Positive test for ANCA-autoantibodies

3. GPA and MPA participants with severe active disease

Key exclusion criteria:

1. Any condition that could prevent a complete washout of medications or couldotherwise make the participant ineligible for anti-CD19 CAR-T therapy and furtherparticipation in the study

2. Hypersensitivity and/or contraindications to any product to be given to theparticipant as part of the study protocol

3. Other systemic autoimmune diseases requiring therapy

4. Any medical conditions that are not related to GPA/MPA that would jeopardize theability of the participant to tolerate CD19 CAR-T cell therapy

5. Inadequate organ function