A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

Last updated: March 31, 2026
Sponsor: Verve Therapeutics, Inc.
Overall Status: Active - Recruiting

Phase

1

Condition

Hypercholesterolemia

Chest Pain

Thrombosis

Treatment

VERVE-102

Clinical Study ID

NCT06164730
VT-10201
  • Ages 18-70
  • All Genders

Study Summary

VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease (CAD) Who Require Additional Lowering of LDL-C. VERVE-102 Uses Base-editing Technology Designed to Disrupt the Expression of the PCSK9 Gene in the Liver and Lower Circulating PCSK9 and LDL-C. This Study is Designed to Determine the Safety and Pharmacodynamic Profile of VERVE-102 in This Patient Population.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of HeFH or premature CAD

Exclusion

Exclusion Criteria:

  • Homozygous familial hypercholesterolemia

  • Active or history of chronic liver disease

  • Current treatment with PCSK9 inhibitor or prior treatment within specified timeframe

  • Clinically significant or abnormal laboratory values as defined by the protocol

Study Design

Total Participants: 85
Treatment Group(s): 1
Primary Treatment: VERVE-102
Phase: 1
Study Start date:
April 30, 2024
Estimated Completion Date:
August 31, 2027

Connect with a study center

  • Clinical Study Center

    Adelaide,
    Australia

    Active - Recruiting

  • Clinical Study Center

    Adelaide 2078025,
    Australia

    Site Not Available

  • Clinical Study Center

    Melbourne,
    Australia

    Active - Recruiting

  • Clinical Study Center

    Melbourne 2158177,
    Australia

    Site Not Available

  • Clinical Study Center

    Sydney,
    Australia

    Site Not Available

  • Clinical Study Center

    Sydney 2147714,
    Australia

    Site Not Available

  • Clinical Study Center

    Chicoutimi,
    Canada

    Active - Recruiting

  • Clinical Study Center

    Chicoutimi 5921225,
    Canada

    Site Not Available

  • Clinical Study Center

    Montreal,
    Canada

    Active - Recruiting

  • Clinical Study Center

    Montreal 6077243,
    Canada

    Site Not Available

  • Clinical Study Center

    Toronto,
    Canada

    Active - Recruiting

  • Clinical Study Center

    Toronto 6167865,
    Canada

    Site Not Available

  • Clinical Study Center

    Vancouver,
    Canada

    Active - Recruiting

  • Clinical Study Center

    Vancouver 6173331,
    Canada

    Site Not Available

  • Clinical Study Center

    Rehovot,
    Israel

    Active - Recruiting

  • Clinical Study Center

    Rehovot 293725,
    Israel

    Site Not Available

  • Clinical Study Center

    Christchurch,
    New Zealand

    Active - Recruiting

  • Clinical Study Center

    Christchurch 2192362,
    New Zealand

    Site Not Available

  • Clinical Study Center

    Birmingham,
    United Kingdom

    Active - Recruiting

  • Clinical Study Center

    Birmingham 2655603,
    United Kingdom

    Site Not Available

  • Clinical Study Center

    Edinburgh,
    United Kingdom

    Active - Recruiting

  • Clinical Study Center

    Edinburgh 2650225,
    United Kingdom

    Site Not Available

  • Clinical Study Center

    London,
    United Kingdom

    Active - Recruiting

  • Clinical Study Center

    London 2643743,
    United Kingdom

    Site Not Available

  • Clinical Study Center

    Manchester,
    United Kingdom

    Active - Recruiting

  • Clinical Study Center

    Manchester 2643123,
    United Kingdom

    Site Not Available

  • Clinical Study Center

    Nottingham,
    United Kingdom

    Active - Recruiting

  • Clinical Study Center

    Nottingham 2641170,
    United Kingdom

    Site Not Available

  • Clinical Study Center

    Dothan, Alabama 36305
    United States

    Active - Recruiting

  • Clinical Study Center

    Dothan 4059102, Alabama 4829764 36305
    United States

    Site Not Available

  • Clinical Study Center

    Pomona, California 91768
    United States

    Active - Recruiting

  • Clinical Study Center

    Boca Raton, Florida 33434
    United States

    Active - Recruiting

  • Clinical Study Center

    Jacksonville, Florida 32216
    United States

    Active - Recruiting

  • Clinical Study Center

    Winter Park, Florida 32789
    United States

    Active - Recruiting

  • Clinical Study Center

    High Point, North Carolina 27260
    United States

    Active - Recruiting

  • Clinical Study Center

    High Point 4471025, North Carolina 4482348 27260
    United States

    Site Not Available

  • Clinical Study Center

    DeSoto, Texas 75115
    United States

    Active - Recruiting

  • Clinical Study Center

    DeSoto 4685524, Texas 4736286 75115
    United States

    Site Not Available

  • Clinical Study Center

    Renton, Washington 98057
    United States

    Active - Recruiting

  • Clinical Study Center

    Renton 5808189, Washington 5815135 98057
    United States

    Site Not Available

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