Biennial CEM in Women With a Personal History of Breast Cancer

Inclusion Criteria:

• Asymptomatic women, ages 30-79, with a personal history of breast cancer who are atleast one year out from any breast cancer surgery and/or treatment and are scheduledto have a routine annual mammogram with tomosynthesis (DBT).

Exclusion Criteria:

• Women with a history of prior moderate or severe iodinated contrast reaction [onlythose with a prior mild reaction that can be managed by pre-medication AND with anda strong desire to participate will be allowed to participate. However, among thesewomen with a mild sensitivity, if they are allergic to Benadryl (one of thepremedications), they will be excluded].

• Women with implant(s) in the breasts to be screened (as this creates artifacts anddiagnostic performance of imaging in women with implants likely does not generalizeto those without implants, and the sample size with implants would be too small toinfer conclusions.

• Women who have had bilateral mastectomy

• Women with a history of kidney failure or estimated glomerular filtration rate (eGFR) < 45 mL/min

• Pregnancy or lactation

• Women actively being treated for cancer of any type with chemotherapy

• Having only one kidney

• Women with stage 4 metastasis to visceral areas or brain

• Women who have a screening breast MRI exam within 24 months prior to the currentround of CEM.

• Women who had a CEM exam within the prior 23 months