Memory Preservation of Hippocampal Avoidance Whole Brain Radiotherapy

Last updated: August 26, 2018
Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neoplasm Metastasis

Brain Metastases

Treatment

N/A

Clinical Study ID

NCT03247127
KMUHIRB-E(II)20170081
  • Ages 20-80
  • All Genders

Study Summary

The study aimed to investigate the memory preservation and neurocognitive function protection of hippocampal avoidance whole brain radiotherapy (HA-WBRT) among people who speak Mandarin Chinese or Taiwanese.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with brain metastases, the brain metastases are located 5mm outside thehippocampus

  • Pathologically proven diagnosis of nonhematopoietic malignancy other than germ cellmalignancy

  • No psychologic disorders

  • Radiation Therapy Oncology Group recursive partitioning analysis class I or II

  • First or second language: Mandarin Chinese or Taiwanese

  • Signed the inform consensus

Exclusion

Exclusion Criteria:

  • Less than 20 years old

  • Leptomeningeal metastases or hydrocephalus

  • Previous radiotherapy to head and neck region

  • Creatinine >1.5mg/dl

  • More than 2 extracranial metastases

  • Patients who cannot tolerate memory or neurocognitive function test or cannot completeQoL questionnaire

Study Design

Total Participants: 30
Study Start date:
March 27, 2017
Estimated Completion Date:
December 31, 2020

Study Description

Brain metastasis is very common, about 30% incidence rate for all patients with a diagnosis of cancer. The rising incidence of brain metastasis is most likely due to recent advances in systemic therapy, and use of magnetic resonance imaging (MRI). The most common primary site is the lung followed by breast. One of the standard treatments is whole brain radiotherapy; it can prolong the decline of neurocognitive function and improve quality of life. However, it can also cause decline in neurocognitive function as a late sequela. Memory impairment is the main cognitive function that affected by radiotherapy, and the neuronal stem cells located at hippocampal subgranular zone are highly sensitive to radiotherapy. There have been large randomized trials confirming that by HA-WBRT, the neurocognitive function decline can be reclaimed. In Taiwan, HA-WBRT is a popular and emerging treatment. However, not much study focused on its effects on neurocognitive function. The study is aimed to objectively investigate the memory preservation and neurocognitive function protection of HA-WBRT in people speaking Mandarin Chinese or Taiwanese by utilizing neurocognitive function test and QoL questionnaire.

Connect with a study center

  • Fang, Pen-Tzu

    Kaohsiung, 80660
    Taiwan

    Active - Recruiting

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