Pharmacology Research Institute, Los Alamitos

Center Information

Charles S. Wilcox, Ph.D.
Executive Director
Pharmacology Research Institute, Los Alamitos
4281 Katella Avenue, Suite 115
Los Alamitos, CA 90720

Video Presentations

Currently Enrolling Trials

[Show More]

Therapeutic Areas

Family Medicine


Pharmacology Research Institute (PRI) is an independent scientific research organization which began to conduct clinical studies for both domestic and foreign pharmaceutical companies in 1975. Referrals to the Institute's three offices are made by private medical/mental health professionals, agencies, health care facilities, family members, friends, or by the individuals themselves. All of PRI's services are provided AT NO CHARGE to the public.

PRI's Mission Statement:

To provide the highest quality of service for the well being of our patients in an environment that provides professional, courteous and friendly service.

To advance knowledge in the area of pharmaceutical medicine, conducting scientifically valid and reliable research studies that contribute to the maintenance and improvement in one's health and quality of life.

To maintain an environment where teamwork and camaraderie flourish, enabling us to be productive and professional in an enjoyable atmosphere.

To promote a spirit of collaboration and involvement that encourages scientific inquiry, productivity, pride and professional development.


PRI has been involved in clinical research since 1975. We focus on research phases II, IIB, III, III-B, and IV.

Our staff is experienced in psychiatry, neurology, ophthalmology, family practice, and gerontology.

We have worked previously with the following sponsors:

  • Abbott
  • Accera
  • A.H. Robins
  • Alcobra
  • Alcon
  • Alkermes, Inc.
  • Allergan
  • American Cyanamid
  • Amgen
  • Angelini
  • Arena Pharmaceuticals, Inc.
  • Arteaus Therapeutics
  • Assurex
  • Astra
  • Ayerst
  • Bayer
  • Beecham Pharmaceuticals
  • Berlex
  • Biovail Laboratories
  • Boehringer-Ingelheim
  • Boots Pharmaceuticals
  • Bristol-Myers Squibb
  • Burroughs-Wellcome
  • Cephlon, Inc.
  • Cerecor
  • Ciba-Geigy, Inc.
  • CoCensys
  • CoLucid
  • Eisai, Inc.
  • Elan Pharmaceuticals
  • Eli Lilly
  • Endo Pharmaceuticals, Inc.
  • Envivo
  • Enzymotec
  • E.R. Squibb
  • Forest Laboratories
  • Fujisawa
  • G.D. Searle & Co.
  • Genentech
  • Glaxo
  • GlaxoSmithKline
  • H. Lundbeck
  • Hoechst-Roussel
  • Hoffman-LaRoche
  • ICI America, Inc.
  • Indevus Pharmaceuticals
  • Innapharma
  • Ives Laboratories
  • Janssen Alzheimer Immunotherapy
  • Janssen Research Foundation
  • Johnson & Johnson Pharmaceutical
  • Kali-Duphar
  • Knoll Pharmaceuticals
  • Lederle, Inc.
  • Lipha Pharmaceuticals
  • Lorex Pharmaceuticals

  • Marrion Merrell-Dow
  • McNeil Laboratories
  • Mead-Johnson Pharmaceuticals
  • Medivation
  • Merck & Co.
  • Merrel-Dow
  • Methylation Sciences, Inc.
  • Miles Laboratories
  • Nabi Pharmaceuticals
  • National Institutes of Health (NIDA)
  • Naurex, Inc.
  • NeuroSearch, Inc.
  • Neurotrope
  • Novartis
  • Organon, Inc.
  • Ortho Pharmaceuticals
  • Otsuka America
  • Parke-Davis
  • Pfizer, Inc.
  • Pharmacia-Upjohn
  • PrecisionMed
  • Purdue-Frederick
  • R.W. Johnson, Co.
  • Reckitt & Colman
  • Reid-Rowell
  • Rhone Poulenc Rorer
  • Roche
  • Roerig, Inc.
  • Rorer Central Research
  • Sandoz, Inc.
  • Sanofi Aventis
  • Sanofi-Synthlabo Research
  • Sepracor
  • Shire Pharmaceutical Development
  • SmithKline Beecham
  • Solvay
  • Somerset
  • Stuart Pharmaceuticals, Inc.
  • Takeda-Abbott
  • TAP Pharmaceuticals
  • Teva Branded Pharmaceutical Products
  • UCB
  • Upjohn Co.
  • U.S. Veterans Administration
  • Vanda Pharmaceuticals
  • Vela Pharmaceuticals
  • Vernalis, Ltd.
  • Vinoxen Company
  • Warner-Lambert
  • Whitehall Laboratories
  • Wyeth-Ayerst
  • Yamanouchi
  • Zeneca


PRI has internationally recognized expertise in pharmacological and multi-dimensional research. Diagnostic categories treated include depression, anxiety, diabetes, insomnia, migraine headaches, mild cognitive impairment, panic disorder, post-traumatic stress disorder, and Alzheimer's Disease. We have outpatient clinics in Newport Beach, Encino, and Los Alamitos, making PRI easily accessible to persons in Orange County, Los Angeles County, including the San Fernando Valley.


Don F. DeFrancisco, M.D., Ph.D.
Areas of Expertise: CNS/Neurological Research

Clifford R. Feldman, M.D., J.D.
Areas of Exertise: CNS/Neurology

Daniel E. Grosz, M.D.
Areas of Expertise: CNS/Neurology/Psychopharmacology

Nader Oskooilar, M.D., Ph.D.
Areas of Expertise: CNS/Neurology/Geriatric

Charles S. Wilcox, Ph.D.
Areas of Expertise: CNS/PK + Phases I-IV

David A. Rosenberg, M.D.
Area of Expertise: CNS/Neurology


The clinical staff expertise and experience at PRI is unparalleled! Working closely with our team of Board Certified physicians, we have several Masters Degreed RNs with an average experience level of more than fifteen years. Our Senior Clinical Research Coordinators, Judy L. Morrissey, R.N., M.S.N., My-Linh Tong, R.N., M.S.N., N.P., Mellissa Henry, R.N., M.S.N., N.P. and Lynn Badgett, R.N., B.S.N., C.C.R.C. have more than 60 years of combined clinical research experience. PRI's utilization of a clinical team concept, whereby our physicians work together with our Masters Degreed Nurse Practitioners, Clinical Nurse Specialists, Bachelor’s Degreed Research Nurses and Clinical Research Coordinators, enables the Institute to provide the most optimal, yet appropriate, research experience for all of our study participants. Moreover, the reliability and validity of data generated by the PRI research team is consistently categorized as being of the utmost quality.

In an era when so many organizations are scaling down on the education and experience levels required in order to work in research, PRI has held steadfast to its core values and competencies. We believe that our adherence to these high standards uniquely and consistently positions us to provide both our program participants and our grant sponsors with the best research experience possible! We thank you for your time and consideration.


PRI's offices are conveniently and strategically located in the San Fernando Valley (population of 1.8 million), the Los Angeles County area (population of 9.8 million), and the Orange County area (population of 3 million). Each population base is demographically distinct, ranging from 22% to 64% non-white in race. Similar diversity in age, education, language, and income can also be targeted for special studies.


Our Commitment to Quality Research:

Beginning in the 1970s, PRI has consistently maintained a team-oriented working environment which we believe is very conducive to providing the most optimal treatment for our study participants. The board-certified physicians and Masters and Bachelors level nurses at PRI not only possess outstanding clinical expertise, they also consistently convey qualities that are truly exemplary of a "caring" health care provider. Our well-educated and highly-experienced team members are dedicated to providing the best care possible to the patients and communities that we serve.

PRI's outpatient clinics are located at the following addresses:

1601 Dove St., Suite 290
Newport Beach, CA 92660
Phone: 949-752-7910
Fax: 949-752-1412

6345 Balboa Blvd.
Building III, Suite 363
Encino, CA 91316
Phone: 818-705-7450
Fax: 818-705-7454

4281 Katella Avenue, Suite 115
Los Alamitos, CA 90720
Phone: 714-827-3667
Fax: 714-827-3669

For the location nearest you, please call us toll-free (in California) at 1-888-PRI-HOPE.

Contact Center

If you are interested in contacting this center to discuss clinical trials, please complete and send the email form below. A representative from the research center will then follow up with you.