MediSphere Medical Research Center, LLC

Center Information

Carrisa "Carrie" Covert, BS, CCRC
MediSphere Medical Research Center, LLC
1401 Professional Boulevard, Suite 100
Evansville, IN 47714
812-471-4110 or (800) 937-5373 (toll-free)

Currently Enrolling Trials

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Therapeutic Areas

Cardiology/Vascular Diseases
Family Medicine
Hepatology (Liver, Pancreatic, Gall Bladder)
Infections and Infectious Diseases
Nutrition and Weight Loss
Obstetrics/Gynecology (Women’s Health)
Otolaryngology (Ear, Nose, Throat)
Pulmonary/Respiratory Diseases


MediSphere is an independent, dedicated clinical research company which conducts Phase II, III and IV clinical research for pharmaceutical, biotechnology, nutritional and medical device industries. Founded in 1992, MediSphere has participated in more than 500 national and multinational clinical trials.

MediSphere has more than 25,000 active patient files in Evansville, IN, the major city in the Tri-State area. The Tri-State, with a population of 1.2 million, is composed of 11 counties in Southwest Indiana, 9 in Western Kentucky and 10 in Southeast Illinois.

MediSphere is a member or the Alliance for Multispecialty Research (AMR), an Independent Site Alliance (ISA) of established, geographically diverse, professional clinical research sites. This not-for-profit support organization is composed of 24 multi-therapeutic, highly experienced research centers across the United States.



  • Allergic Rhinitis


  • Angina Pectoris
  • Congestive Heart Failure
  • Coronary Artery Disease
  • Echocardiography - NIDDM & Weight Loss Products
  • Essential Hypertension
  • Intermittent Claudication
  • Intermittent Claudication in Diabetics
  • Renal Protection in CABG
  • Venous Stasis Ulcers

Central Nervous System:

  • Depression, Treatment-Resistant
  • Major Depression
  • Primary Insomnia
  • Diabetic Foot Ulcers
  • Genital Herpes
  • Herpes Labialis
  • Herpes Zoster
  • Skin & Soft Tissue Infections
  • Tenia Pedis
  • Venous Stasis Ulcers


  • Diabetes Mellitus
  • Dyslipidemias
  • Dyslipidemias in NIDDM
  • Hormone Replacement Therapy
  • Obesity
  • Obesity in NIDDM


  • Duodenal Ulcer & Gastric Ulcer
  • Gastric Protection (NSAIDS)
  • Gastroesophageal Reflux Disease (GERD)
  • Heartburn
  • Heartburn - Provocative Meal Studies
  • Irritable Bowel Syndrome (IBS)
  • Non-Ulcer Dyspepsia

Infectious Diseases:

  • Acute Bronchitis
  • Acute Bacterial Exacerbation of COPD
  • Acute Sinusitis
  • Community Acquired Pneumonia
  • Complicated Urinary Tract Infection
  • Diabetic Foot Ulcers
  • Genital Herpes
  • Helicobacter Pylori
  • Herpes Labialis
  • Herpes Zoster
  • Influenza
  • Lower Urinary Tract Infection
  • Otitis Externa
  • Skin & Skin Structure Infections - Complicated and Uncomplicated
  • Skin & Soft Tissue Infection
  • Streptococcal Pharyngitis
  • Urinary Tract Infection, Complicated/Uncomplicated
  • Vulvovaginal Candidiasis

Medical Devices:

  • Anticoagulant Monitoring
  • Antiseptic-Coated Central Venous Catheter
  • Blood Gas Analyzer
  • Home Health Care Monitoring Products
  • Ionophoretic Drug Delivery Systems
  • Point-Of-Care Diagnostic & Monitoring Health Care Facilities Products
  • Rapid Screening for Influenza A & B


  • Acute Ankle Sprain
  • Acute Epicondylitis
  • Osteoarthritis
  • Osteoporosis
  • Osteoporosis Prevention
  • Rheumatoid Arthritis
  • End Stage Renal Disease
  • Hemodialysis
  • Peritoneal Dialysis


  • Diabetic Neuropathy
  • Migraine Headache, Adult and Adolescent
  • Parkinson's Disease


  • Hearing Impairment Testing
  • Otitis Externa
  • Pharyngitis
  • Sinusitis


  • Acute Epicondylitis
  • Acute Ankle Sprain
  • Acute Low Back Pain
  • Chronic Back Pain
  • Chronic Pain Syndromes
  • Pain due to Osteoarthritis
  • Painful Diabetic Neuropathy
  • Post-Herpetic Neuralgia

Pharmacokinetic Studies:

  • Outpatient Pharmacokinetics


  • Acute Bronchitis
  • Acute Exacerbation of Chronic Bronchitis
  • Bronchial Asthma
  • Chronic Bronchitis
  • Chronic Obstructive Pulmonary Disease - COPD
  • Community Acquired Pneumonia
  • Exercise-Induced Asthma

Special Formulations:

  • Inhalation Therapy
  • Intranasal Therapy
  • Iontophoretic Drug Delivery Systems
  • Orally Disintegrating Tablet
  • Rx to OTC Switch
  • Sustained/Extended Release
  • Topical Therapy
  • Transdermal Delivery Systems

Special Populations:

  • Elderly
  • Pediatric & Adolescent
  • Renal Impairment


  • Benign Prostatic Hypertrophy
  • Complicated Urinary Tract Infection
  • Lower Urinary Tract Infection (Cystitis)
  • Overactive Bladder
  • Pyelonephritis
  • Uncomplicated Urinary Tract Infection
  • Urge, Stress and Mixed Incontinence

Women's Health Care:

  • Genital Herpes
  • Hormone Replacement Therapy
  • Irritable Bowel Syndrome in Women
  • Lower Urinary Tract Infection (Cystitis)
  • Osteoporosis, Osteoporosis Prevention
  • Selective Estrogen Regulator Modulators
  • Vulvovaginal Candiasis

On-Site Equipment/Services:
  • Emergency Equipment: Crash Cart, Automated External Defibrillator
  • Diagnostics: ECG, phlebotomy, Laboratory for Processing & Shipping Specimens, Pulmonary Function Testing (Puritan Bennett - 100), Doppler, Holter Monitoring & Ambulatory Blood Pressure Monitoring (ABPM) Capability, Mercury Sphygmomanometers
  • Equipment: Refrigerator - Not Frost Free, -20° Freezer, Fax Machines, Dry Ice, Locked, Temperature Controlled Drug Storage, Centrifuge
  • Services: Diet Counseling, Certified Clinical Research Coordinators, Remote Data Entry (Including Internet Access). Full time Physicians on site. Comprehensive SOP's (available on request), OSHA Compliant, CLIA Certified for Provider Performed Microscopy, FAA - Bio-hazard Certification. Compliant with GCP/ICH Guidelines for Informed Consent Process.

Available Services: Diagnostic Radiography, Ultrasonography, Computerized Tomography, Magnetic Resonance Imaging, Hologic DEXA, Body Composition Analysis, Exercise Treadmill Testing, Echocardiography, Nuclear Cardiac Imaging, Nuclear Imaging, Certified Vascular Laboratory, Renal Dialysis, Peritoneal Dialysis Urodynamics, Endometrial Biopsy, Ophthamology

MediSphere Medical Research Center, LLC, Industry Sponsors:

  • 3M Pharmaceuticals
  • Abbott Laboratories
  • Agouron
  • Ajinomoto Pharmaceuticals
  • Alcon
  • Allergan
  • Alpharma USPD, Inc.
  • Alza Pharmaceuticals
  • Amgen Inc.
  • Amylin Corporation
  • Astra Merck
  • Astra Pharmaceuticals
  • AstraZeneca
  • Aura Laboratories, Inc.
  • Aventis
  • Bayer Corporation
  • Boehringer-Ingelheim
  • Boehringer-Mannheim
  • Bristol-Myers Squibb
  • Dey Pharmaceuticals
  • DuPont Pharmaceutical Company
  • Drug Delivery Technologies, Inc.
  • Endo Pharmaceuticals
  • Eli Lilly & Co.
  • Ethical Pharmaceuticals Ltd
  • G. D. Searle Pharmaceuticals
  • GelTex
  • Genentech, Inc.
  • GlaxoSmithKline
  • Glaxo-Wellcome
  • Hoechst Marion Roussel
  • HYAL Pharmaceuticals
  • Interneuron Pharmaceuticals, Inc.
  • IOMED, Inc.
  • Janssen Pharmaceutical Research Institute
  • Johnson & Johnson
  • Knoll Pharmaceutical Company
  • Lorex Pharmaceuticals
  • Marion Merrill Dow
  • Merck Human Health Division
  • Merck Research Laboratories
  • Milkhaus Laboratories
  • MSP Singapore Company LLC
  • Neurocrine Biosciences, Inc.
  • Novartis
  • Nycomed Salutar, Inc.
  • Ortho-McNeil Pharmaceuticals, Inc.
  • Otsuka America Pharmaceuticals
  • Parke-Davis Pharmaceuticals
  • Perrigo Company
  • Pfizer Inc.
  • Pharmacia & Upjohn
  • Pozen Inc.
  • Praecis Pharmaceuticals Inc.
  • Procter & Gamble Corp.
  • Purdue Pharma
  • Quidel Inc.
  • Recordati S.p.A.
  • R.W. Johnson Pharmaceutical Research Institute
  • Rhone-Poulenc Rorer
  • Roberts Pharmaceuticals
  • Roche Laboratories
  • Roche Bioscience
  • Roche Diagnostics
  • Sankyo, USA
  • Schering Plough
  • Schwarz Pharma
  • Sepracor, Inc.
  • Sigma Tau Research
  • SmithKline Beecham
  • Solvay Pharmaceuticals, Inc.
  • Syntex Laboratories, Inc.
  • Takeda America, Inc.
  • TAP Holdings, Inc.
  • United Therapeutics Corp.
  • Vanguard Medica Ltd.
  • Viropharma
  • Vyteris
  • Whitehall Robins
  • Wyeth Ayerst
  • Zeneca Pharmaceuticals

MediSphere Medical Research Center, LLC, Contract Research Organization (CRO) Sponsors:

  • Barton & Polansky
  • Berger & Boyer
  • BioPharm
  • Boston Health Care Associates
  • Bradstreet Clinical Research Associates
  • Clinical Trials Management Services (CTMS)
  • Clinimetrics Research Associates
  • ClinTrials, Inc.
  • Concepts in Pharmaceutical Research (CPR)
  • Corning Besselaar, Inc.
  • Collaborative Clinical Research
  • Covalent Research Alliance, Inc.
  • Covance
  • Healthcare Products Development
  • IBRD/Phoenix
  • ICON
  • Ingenix
  • Innovex, Inc.
  • Integrated Research
  • Kendle International
  • Kern McNeill International
  • Kunitz & Associates, Inc.
  • Lineberry Associates
  • MIMC
  • MedPace
  • MTRA
  • NutraTec, Inc.
  • Paragon Biomedical Inc.
  • Parexel International Corporation
  • Pharmaceutical Research Associates (PRA)
  • Pharmakenetics, Inc.
  • PharmaNet, Inc.
  • Phoenix International Life Sciences
  • PPD Development
  • PPD Pharmaco
  • Premier Research Worldwide
  • Quintiles, Inc.
  • Quintiles/BRI
  • Scientific Data Inc. (SDI)
  • SCIREX Corporation
  • TAB Consulting, Inc.
  • Target Research Associates
  • World Wide Clinical Research


MediSphere is a state-of-the-art, modern medical research facility, 9,300 square feet, completed in early 2002.


Hubert S. Reyes, M.D. is certified by the American Board of Family Practice. He holds the following certifications: Pediatric Advance Life Support (PALS), Basic Cardiac Life Support (BCLS), Advance Cardiac Life Support (ACLS), and Advance Life Support in Obstetrics (ALSO).

Alexander Dela Llana, M.D. is certified by the American Board of Family Practice. He has over 9 years' experience in clinical research trials, and has participated in over 300 studies.

Mike Sebastian, M.D. is certified by the American Board of Family Practice. He has 9 years' experience in clinical research trials, and has participated in over 300 studies.

Mary "Sammie" Rutherford, RN, BSN, MSN, FNP. Nationally certified by the American Academy of Nurse Practitioners with over 25 years’ experience in advanced practice and over 10 years’ experience in clinical research

FDA Audits in October 1999, May 2001, September 2006, and November 2008 three showed no deficiencies and no 483's issued.


MediSphere's clinical staff consists of the following members:

Chief Operating Officer
John Wathen, B.S.

Principal Investigators:

  • Alexander E. Dela Llana, MD
  • Hubert S. Reyes, MD
  • Mike Gerald A. Sebastian, MD

Sub Investigators:

  • Mary "Sammie" Rutherford, RN, BSN, MSN, FNP
  • Steven K. Elliott, MD

Operations Manager
Kim Dwojak

Administrative Staff
Lesa Woodruff, BS
Contracts Administrator

New Business Development
Perla Dela Llana

Clinical Research:

Carrie Covert, BS, CCRC
Manager, Clinical Studies

Lene Grace Nibungco, M.D.
Recruitment Manager

Aaryn Clayton
Clinic Research Coordinator

Maribel N. Nuestro BSN, PBT, (ASCP-CM)
Clinic Research Coordinator

Sherri Scheller, BS
Clinic Secretary

Ted Nora, BS
Data Entry Coordinator & Regulatory Assistant

Regulatory Department:

Anna Bruggenschmidt
Regulatory Affairs Administrator


Our patients come from southwest Indiana, western Kentucky, and southeast Illinois. The population is relatively stable and non-transient. MediSphere selects patients who are reliable and compliant with medical regimens. We have more than 26,000 patient profiles in our computerized Patient Tracking System.


For more information, contact:

MediSphere Medical Research Center
1401 Professional Blvd.
Suite 100
Evansville, IN 47714
Phone: 812-471-4110
Fax: 812-471-4275
Web Site:

Contact Center

If you are interested in contacting this center to discuss clinical trials, please complete and send the email form below. A representative from the research center will then follow up with you.