Clinical Physiology Associates

Center Information


Clinical Physiology Associates
13670 Metropolis Avenue, Suite 105
Fort Myers, FL 33912
239-936-4421
239-936-2865
studycenter@clinphys.com
www.clinicalstudycenter.com

Currently Enrolling Trials

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Therapeutic Areas

Dermatology
Devices
Endocrinology
Family Medicine
Gastroenterology
Healthy Volunteers
Infections and Infectious Diseases
Internal Medicine
Neurology
Nutrition and Weight Loss
Obstetrics/Gynecology (Women’s Health)
Oncology
Rheumatology
Sleep
Urology
Vaccines

Performance Metrics

Number of Studies Conducted: 626
Regulatory Submission Turn-Around Time: 3 Business Day(s)
Average Percent of ‘Completed’ Studies that met Enrollment Goals: 85%
EDC Capabilities: Yes

Overview

Clinical Physiology Associates, a multispecialty research group,has been conducting clinical trials for the pharmaceutical andmedical device industries for 35+ years. The use of central IRBsand laboratories are preferred. Turn around time for regulatorydocuments is less than 3 days. 

Experience

CPA Studies by discipline

Numbers within ( ) refer to the number of different medicinesstudied. Some medicines were studied in more than one protocol

Cardiology
  • Angina pectoris, chronic stable (30)
  • Congestive heart failure (9)
  • Hypertension (41)
  • Peripheral vascular disease (7)
  • Ventricular arrhythmias (4)
Central Nervous System
  • Alzheimer's disease (9)
  • Migraine headaches (5)
  • Seizure prophylaxis (4)
  • Stroke (ischemic) (1)
  • Tension headaches (1)
Dermatology
  • Psoriasis (1)
  • Tinea Cruris (1)
  • Tinea Pedis (1)
Endocrinology
  • Diabetes mellitus (7)
  • Diabetic neuropathy (15)
  • Obesity (2)
Gastroenterology
  • Acid Indigestion (1)
  • Constipation - opiate induced (1)
  • Gastroesophageal Reflux (chronic) (1)
  • Heart burn (1)
  • Irritable bowel syndrome – diarrhea predominant (4)
  • Irritable bowel syndrome – constipation predominant(1)
Genitourinary
  • Acute Urinary Retention (1)
  • Benign prostatic hyperplasia (11)
  • Bladder Cancer (superficial) (1)
  • Genital Herpes (3)
  • Hypogonadism [male] (1)
  • Impotence [erectile dysfunction] (15)
  • Impotence [erectile dysfunction] in spinal cord injury (1)
  • Impotence + dyslipidemia (1)
  • Nocturia (1)
  • Premature (rapid) ejaculation (1)
  • Premature (rapid) ejaculation + erectile dysfunction (1)
  • Prostate cancer (6)
  • Prostate Cancer Prevention (1)
  • Prostatitis (chronic) (2)
  • Sexual dysfunction (female) (6)
  • Sexual dysfunction (male & female) (1)
  • Urinary incontinence [urge, stress, mixed] (14)
  • Urinary tract infection [complicated, uncomplicated](5)
Geriatrics
  • Chronic obstructive pulmonary disease (5)
  • Congestive heart failure (9)
  • Herpes zoster [shingles] (2)
  • Insomnia [elderly] (4)
  • Postherpetic neuralgia (9)
Gynecology
  • Contraception (2)
  • Osteopenia (1)
  • Osteoporosis (postmenopausal) (5)
  • Postmenopausal hormone replacement therapy (17)
  • Postmenopausal hormone substitute replacement therapy (1)
  • Premenstrual Dysphoric Disorder (PMDD) (2)
  • Premenstrual syndrome (PMS) (1)
  • Sexual dysfunction [women only] (6)
  • Sexual dysfunction [women & men] (1)
Internal medicine
  • Acid indigestion (1)
  • Angina pectoris (30)
  • Asthma (5)
  • Bronchitis (4)
  • Chronic obstructive pulmonary disease [COPD] (5)
  • Congestive heart failure [CHF] (9)
  • Constipation- opiate induced (2)
  • Diabetes mellitus (7)
  • Diabetic neuropathy (15)
  • Internal medicine, contd.
  • Diabetic neuropathic ulcers (2)
  • Gastroesophageal reflux (1)
  • Genital herpes (3)
  • Heartburn (1)
  • Hemorrhoids (1)
  • Herpes labialis (cold sores) (4)
  • Herpes zoster (shingles) (2)
  • Hypercholesterolemia (2)
  • Hypertension (41)
  • Hypertension + Osteoarthritis (1)
  • Infectious diseases [miscellaneous] (22)
  • Insomnia (2)
  • Insomnia [elderly] (4)
  • Irritable bowel syndrome (2)
  • Migraine headache (5)
  • Obesity (2)
  • Osteoarthritis (14)
  • Pain management (18)
  • Peripheral vascular disease (7)
  • Post- herpetic neuralgia (9)
  • Rheumatoid arthritis (1)
  • Sea sickness (1)
  • Skin & soft tissue infections (13)
  • Smoking cessation (1)
  • Tension headaches (1)
  • Urinary tract infections (5)
Miscellaneous
  • Sinusitis (2)
  • Venous Stasis Ulcers (2)
Neurology
  • Alzheimer's disease (9)
Oncology
  • Head & neck cancer (1)
  • Prostate cancer (8)
  • Prostate cancer prevention (1)
  • Prostatic intraepithelial neoplasia (PIN) (1)
  • Superficial bladder cancer (1)
Ophthalmology
  • Allergic conjunctivitis (1)
  • Bacterial Conjunctivitis (1)
  • Corneal Ulcer (1)
  • Ophthalmic Zoster (1)
Otolaryngology
  • Head & neck cancer (1)
  • Sinusitis (1)
Pharmacology
  • Hypogonadism (male) (1)
Surgery
  • Alzheimer's disease [neurosurgery] (1)
  • Decubitus ulcers [plastic & reconstructive surgery](1)
  • Diabetic neuropathic ulcers [plastic & reconstructivesurgery] (3)
  • Postoperative pain management [neurosurgery] (3)
  • Postoperative peridural fibrosis [neurosurgery] (2)
  • Scar revision [plastic & reconstructive surgery] (1)
  • Seizure prophylaxis [neurosurgery] (4)
  • Wound healing [plastic & reconstructive surgery](2)

Pharmaceutical Companies worked with:

  • 3M Pharmaceuticals
  • A.H. Robins Company
  • Abbott Laboratories
  • Advanced Care Products
  • Aeterna
  • Alizyme Therapeutics, Ltd.
  • Allergan Pharmaceuticals
  • Alpha Therapeutic Corporation
  • Astellas
  • Astra Pharmaceuticals
  • AstraZeneca
  • Aventis
  • Barr
  • Bayer
  • Bayer Health Care
  • Berlex
  • Biosante
  • Boehringer Ingelheim Pharmaceuticals
  • Boehringer Mannheim Corporation
  • Bristol Myers Squibb Company
  • Burroughs Wellcome Company
  • Cellegy
  • Ciba Geigy Pharmaceutical Corporation
  • ConvaTec
  • Corcept
  • DepoMed
  • DuPont Pharmaceuticals
  • Duramed
  • Eisai
  • Eli Lilly and Company
  • Endo
  • Ethical Pharmaceuticals, Ltd.
  • Eunoe
  • Forest Research
  • FzioMed
  • Galen
  • G.D. Searle and Company
  • GlaxoSmithKline
  • Glaxo Welcome
  • Grunenthal
  • GTx, Inc.
  • Hisamitsu
  • Hoechst Roussel Pharmaceuticals
  • Hoffman LaRoche, Inc.
  • Human Geonome Science
  • IASO Pharma
  • ICI Pharmaceuticals
  • Indivus
  • International Medical Innovations
  • Interneuron Pharmaceuticals
  • Janssen Research Foundation
  • Johnson & Johnson
  • Key Pharm. Div. Schering Corp.
  • Kissei
  • Knoll
  • Labopharm
  • Lemmon Company
  • Lidak
  • Lilly
  • Lorex Pharmaceuticals
  • Lupin Ltd.
  • MacroChem
  • Magainin Pharmaceuticals, Inc.
  • Marion Merrell Dow Laboratories
  • Matrix
  • McNeil Consumer Products
  • McNeil Pharmaceutical
  • Merck
  • Miles Pharmaceuticals
  • Myriad
  • Neurobiological Technologies
  • Neurocrine Biosciences
  • NexMed
  • Nix-O-Tine Pharmaceuticals
  • NicOx SA
  • Novartis
  • Ono
  • Organon
  • Ortho- McNeil
  • Palatin Technologies
  • Parke-Davis
  • Pfizer (Groton)
  • Pfizer (New York)
  • Pharmacia
  • Pharmacia & Upjohn
  • Procter & Gamble
  • ProCyte Corporation
  • Radius Health
  • Reckett and Coleman
  • Reed and Carnrick
  • Revlon Health Care Group
  • Rhone Poulenc Rorer Pharmaceuticals
  • Roberts Pharmaceutical Corporation
  • Roche Bioscience
  • Roche Global Development
  • R.W. Johnson Pharm. Research Institute
  • Salix
  • Sandoz Pharmaceuticals
  • Sangamo
  • Sankyo U.S.A. Corp.
  • Sanofi Synthelabo
  • Schering Corporation
  • Schering Plough Research Institute
  • Schwarz Bioscience
  • Schwarz Pharma
  • Searle
  • Senju
  • Serono Laboratories, Inc.
  • SmithKline and French Laboratories
  • SmithKline Beecham Pharmaceuticals
  • Solvay
  • Sterling Winthrop
  • Stuart Pharmaceuticals
  • Sucampo
  • Sugen
  • Syntex Laboratories
  • Takeda America
  • Takeda Global
  • TAP Holdings
  • Tioga
  • Toyama
  • UCB Pharma
  • Unimed
  • Unither
  • Upjohn Company
  • Upsher Smith
  • USV Pharmaceutical Company
  • Vivus
  • W.F. Merchant Pharmaceutical Corporation
  • Wallace Laboratories
  • Wyeth Ayerst Laboratories
  • Wyeth Research
  • Xanodyne
  • XenoPort
  • Yamanouchi
  • Zeneca

Contract Research Organizations Worked With:1978-Present

  • Barton & Polanski
  • Besselaar Associates
  • BioCLin
  • BioDecision Laboratories
  • BioPharm Clinical Services
  • Clinical Research Consultants
  • Clinical Research Group
  • Clinical Research Institute
  • Clinimetrics
  • Clinical Trial Management Services, Inc.
  • ClinTrials
  • Constella
  • Coromed
  • Covalent Research Alliance
  • Covance
  • Drug Research and Analysis Corporation
  • Health Decisions
  • i3 Research
  • IBRD
  • ICON Clinical Research
  • INC Research
  • Ingenix
  • Institute of Clinical Pharmacology
  • MDA Pharma
  • MDS Pharma Services
  • Medex
  • Medical and Technical Research Associates
  • Metropolitan Research Associates
  • Minnesota Clinical Study Center
  • Omnicare
  • Oxford Research International
  • PACT
  • Paragon Biomedical
  • Parexel
  • Pharmaco
  • Pharmaceutical Product Development
  • Pharmaceutical Resource Corp.
  • PharmaKinetics Laboratories, Inc.
  • PharmaNet
  • Phoenix International
  • PPD Development
  • PPD Pharmaco
  • Quintiles
  • Radiant Development
  • Resource Solutions
  • Scirex

Facility

  • Examination rooms (3)
  • Laboratory work areas (1)
  • Conference rooms [monitor work areas] (3)
  • Double locked limited accesstemperature controlled drug storage room with
    • Shelves
    • Counter tops
    • Refrigerator/ freezer
    • Steel locked controlled substance cabinet
  • Physician dictation area with X-ray view box
  • Video surveillance cameras with remote access
  • Coordinators’ offices (3)
  • Administrative offices (3)
  • Spacious waiting room
  • Rest rooms (2)

SPECIALIZED SCIENTIFIC EQUIPMENT

Urology

  • Dantec Urodyn 1000 urine flowmeter (2)
  • Diagnostics Ultrasound Bladder Scan (2)
  • Rigiscan Plus (with computer interface)
  • Infusion Equipment (IMED Gemini PC-1) (2)

Cardiovascular

  • Parks Penilab V (non- invasive vascular lab)
  • Parks hand-held transcutaneous Doppler flowmeter
  • Parks photoplethysmograph and miscellaneous instruments toperform non-invasive assessments of the peripheral and penilecirculations
  • Hokanson automatic cuff inflator
  • Nihon Kohden Cardiofax V [12 lead EKG] (2)
  • Novametrix transcutaneous oxygen monitor (2 channel)
  • Omron digital blood pressure monitor (3)
  • Quinton Exerdop™

Anthropometry

  • Harpenden Stadiometer

Gynecology

  • Vabra endometrial biopsy aspirator & relatedinstruments

Pulmonary

  • KoKo Spirometer with computer interface

Laboratory (dry ice is available daily)

  • Refrigerator/ freezer -20 degrees Celsius (various)
  • Clinical centrifuges
  • Refrigerated centrifuge (Jouan CR412)
  • Test tube shaker
  • Leitz binocular optical microscope
  • Temp-Blok module heater
  • Corning Biotrack 516

Computers & Related Items

    • High Speed Internet and fax
    • intra- office network
    • Computers

Demographics of the area (July 2009 University of Florida BEBR)

      • Population estimate: 625,124
        • Persons 65+ years of age: 150,029
        • Females 18+ years of age: 255,050
      • Study Center Database: 5071
        • # female patients 3,551
        • # male patients 1,520
        • # of persons 65+ years of age: 2,136
        • # of male patients 65+ years of age: 746
        • # of female patients +65 years of age: 1,390

Investigator

Kevin M. Fleishman, MD.
Board Certified Obstetrics and Gynecology

Pedro Ylisastigui, M.D. 
Board Certified Internal Medicine

Sergio Mather, M.D.
Board Certified Internal Medicine & Endocrinology

Natasha Bower, M.D.
Board Certified Obstetrics and Gynecology

Anais Badia, D.O.
Board Certified Dermatologist

Staff

The study center is staffed with full time study coordinators,coordinators’ assistants and administrative personnel. Allcoordinators and their assistants are trained in shippinginfectious & biological substances as per 49 CFR section172,702 & IATA regulations. All staff members are trained inbasic life support (CPR), HIPAA guidelines for clinical researchersand the protection of human research subjects.

Other

Institutional Review Boards Utilized

    • Chesapeake Research Review, Inc.
    • Coast Institutional Review Board
    • Copernicus Group
    • Essex Institutional Review Board
    • Independent Investigational Review Board, Inc.
    • Integ Review Ethical Review Board
    • Institutional Review Board for Clinical Physiology Associates(disbanded 1993)
    • Lee Memorial Health System Institutional Review Committee
    • New England Institutional Review Board
    • Quorum Review
    • RCRC Institutional Review Board
    • Research Consultants Review Committee Institutional ReviewBoard (RCRC IRB)
    • Schulman Associates Institutional Review Board
    • St. Davids Human Research Review Board
    • Sterling Institutional Review Board
    • Western Institutional Review Board

Contact Center

If you are interested in contacting this center to discuss clinical trials, please complete and send the email form below. A representative from the research center will then follow up with you.