September-October 2019 (Volume 20, Number 5) : PDF
Proof is in the planning for adaptive clinical trial designs
Adaptive clinical trial design has been making its way from oncology and other specialty fields into the broader world of pharmaceutical and biologic studies. While adaptive design can offer many benefits for clinical investigators and sponsors, those conducting such trials can be easily tripped up in two areas: adequate, detailed planning of the design; and data control during the interim analysis that is the hallmark of adaptive design.
How to retain enrolled study subjects and ensure compliance
Clinical trials spend a lot of time on recruiting, screening, enrolling and initiating the right study subjects, but the way a trial works with those subjects also plays a large — and often overlooked — part in its success.