Isentress (raltegravir)
The following drug information is obtained from various newswires, published
medical journal articles, and medical conference presentations.
General Information
Isentress is an orally available human immunodeficiency virus
integrase strand transfer inhibitor. Once a cell is infected with
HIV, its RNA must be converted (reverse transcribed) into DNA.
Integrase, a viral enzyme, helps to hide HIV's DNA inside the
cell's DNA. Integrase inhibitors work by blocking this process,
known as integration. Thus, Isentress prevents HIV DNA from
entering healthy cell DNA.
Isentress, in combination with other antiretroviral agents, is
specifically indicated for the treatment of HIV-1 infection in
treatment-experienced adult patients who have evidence of viral
replication and HIV-1 strains resistant to multiple antiretroviral
agents.
Isentress is supplied as a tablet designed for oral
administration. The recommended initial dose of the drug is 400 mg
administered orally, twice daily with or without food.
Clinical Results
FDA Approval
The FDA approval of Isentress is based on the results of two
clinical trials. These randomized, double-blind, placebo-controlled
trials were dubbed BENCHMARK-1 and BENCHMARK-2. The trials enrolled
treatment-experienced HIV-infected subjects who had failed
antiretroviral therapies (ARTs), and who had HIV virus resistant to
at least one drug in each of the three available classes of oral
ARTs. In both studies, subjects received 400mg or placebo, each
dosed orally twice daily in combination with OBT. The trials were
designed to compare Isentress plus optimized background therapy
(OBT) to placebo plus OBT in terms of reduction in HIV viral load,
change from baseline in CD4 cell counts and evaluation of safety
and tolerability.
BENCHMARK-1
This trial enrolled subjects in Europe, Asia and Peru. The mean
baseline viral load was 4.6 log10 copies/mL and the mean CD4 cell
counts 156 cells/mm3 for the Isentress group and 4.5 log10
copies/mL and 153 cells/mm3, respectively, for the placebo group.
In BENCHMARK-1, 77% of subjects receiving Isentress in combination
with OBT achieved HIV RNA viral load reduction below 400 copies/mL
compared to 41% of subjects receiving placebo plus OBT
(p<0.001). In addition, 61% of subjects receiving Isentress plus
OBT achieved viral load reduction to below 50 copies/mL compared to
33% of those receiving placebo plus OBT (p<0.001). Increases in
CD4 cell counts from baseline were 83 and 31 cells/mm³ for subjects
receiving Isentress and placebo, respectively (p<0.001).
BENCHMARK-2
This trial enrolled subjects in North, Central and South America.
The mean baseline viral load was 4.7 log10 copies/mL for both the
Isentress and placebo groups. The mean CD4 cell counts were 146
cells/mm3 for the Isentress group and 163 cells/mm3 for the placebo
group. In BENCHMARK-2, 77% of subjects receiving Isentress in
combination with OBT achieved HIV RNA viral load reduction to below
400 copies/mL compared to 43% of subjects receiving placebo plus
OBT (p<0.001). In addition, 62% of subjects receiving Isentress
plus OBT achieved RNA viral load reduction to below 50 copies/mL
compared to 36% of those receiving placebo plus OBT (p<0.001).
Increases in CD4 cell counts from baseline were 86 and 40 cells/mm³
for the subjects receiving Isentress and placebo, respectively
(p<0.001). Treatment was generally well tolerated in both
trials.
Side Effects
Adverse events associated with the use of Isentress may include,
but are not limited to, the following:
- Diarrhea
- Nausea
- Headache
- Pyrexia
- Asthenia
- Fatigue
- Dizziness
- Acquired Lipodystrophy
Mechanism of Action
Isentress is an orally available human immunodeficiency virus
integrase strand transfer inhibitor. Inhibition of integrase
prevents the covalent insertion, or integration, of unintegrated
linear HIV-1 DNA into the host cell genome preventing the formation
of the HIV-1 provirus. The provirus is required to direct the
production of progeny virus, so inhibiting integration prevents
propagation of the viral infection.
Literature References
Markowitz M, Nguyen BY, Gotuzzo E, Mendo F, Ratanasuwan
W, Kovacs C, Prada G, Morales-Ramirez JO, Crumpacker CS, Isaacs RD,
Gilde LR, Wan H, Miller MD, Wenning LA, Teppler H; the Protocol 004
Part II Study Team Rapid and Durable Antiretroviral Effect
of the HIV-1 Integrase Inhibitor Raltegravir as Part of Combination
Therapy in Treatment-Naive Patients With HIV-1 Infection: Results
of a 48-Week Controlled Study. Journal of acquired immune
deficiency syndromes 2007 Oct 1;46(2):125-133
Iwamoto M, Wenning LA, Petry AS, Laethem M, De Smet M,
Kost JT, Merschman SA, Strohmaier KM, Ramael S, Lasseter KC, Stone
JA, Gottesdiener KM, Wagner JA Safety, Tolerability, and
Pharmacokinetics of Raltegravir After Single and Multiple Doses in
Healthy Subjects. Clinical pharmacology and therapeutics
2007 Aug 22
Grinsztejn B, Nguyen BY, Katlama C, Gatell JM, Lazzarin
A, Vittecoq D, Gonzalez CJ, Chen J, Harvey CM, Isaacs RD; Protocol
005 Team Safety and efficacy of the HIV-1 integrase
inhibitor raltegravir (MK-0518) in treatment-experienced patients
with multidrug-resistant virus: a phase II randomised controlled
trial. Lancet 2007 Apr 14;369(9569):1261-9
Markowitz M, Morales-Ramirez JO, Nguyen BY, Kovacs CM,
Steigbigel RT, Cooper DA, Liporace R, Schwartz R, Isaacs R, Gilde
LR, Wenning L, Zhao J, Teppler H Antiretroviral activity,
pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of
HIV-1 integrase, dosed as monotherapy for 10 days in
treatment-naive HIV-1-infected individuals. Journal of acquired
immune deficiency syndromes 2006 Dec 15;43(5):509-15
Additional Information
For additional information regarding Isentress or HIV, please
visit the Isentress web page.