National Stroke Foundation


The following drug information is obtained from various newswires, published medical journal articles, and medical conference presentations.

Approval Status:

Approved July 1999

Specific Treatments:


General Information

Cenestin has been approved for the treatment of hot flashes, night sweats, and other moderate-to-severe vasomotor symptoms associated with menopause. Cenestin is a slow-release conjugated estrogen product that is synthesized 100% from soy and yam plants. Premarin, the only other slow-release conjugated estrogen product, is derived from pregnant horses.

Side Effects

In clinical trials, the most frequently reported adverse events were headache and insomnia, which occurred with similar frequency in the placebo group. Pregnant women should not use hormone replacement therapy because of possible risk to the fetus.