The following drug information is obtained from various newswires, published
medical journal articles, and medical conference presentations.
Caverject is the first prescription drug approved for
It is self-injected into the penis shortly before sexual
intercourse. The drug creates an erection by relaxing the smooth
muscle tissue and dilating the major artery in the penis, which
enhances the blood flow to the penis.
The drug's most common side effect is penile pain. Other
side effects include bleeding at the injection site and an
unhealthy, prolonged erection of four to six hours.
Chen, J, Godschalk, M, et al. The Lowest Effective Dose of
Prostaglandin E1 as Treatment for Erectile Dysfunction. The Journal
of Urology 1995; 153: 80-81. Chen, J, Godschalk, M, et al.
Prostaglandin E1 as Treatment for Erectile Failure in Elderly Men,
Journal of American Geriatrics Society 1994; 42:1263-1265.
For the estimated 10 to 20 million American men who suffer from
impotence, Caverject provides an alternative to devices previously
approved by FDA. A vacuum device involves placing a cylinder-like
device and attached pump over the penis. By using the pump, blood
is drawn into the penis, creating an erection. A constriction band
is then placed at the base of the penis to maintain erection. A
second treatment option, the penile implant, involves the surgical
placement of cylinders in the penis and is available in a variety
FDA approved Caverject to treat impotence caused by
neurological, vascular or psychological dysfunction. While
psychological factors such as anxiety and depression can lead to
sexual dysfunction, more than 85% of impotence cases have a
physical cause, according to the Impotence Institute of America. A
complete physical examination is important so that any underlying
condition can be diagnosed and treated. Some common causes of
impotence are diabetes, arteriosclerosis (hardening of the
arteries), and high blood pressure. Also impotence has reportedly
been caused by 16 of the 200 most commonly prescribed drugs,
including drugs for high blood pressure, heart disease, and