Bone and Cancer
Bone and Cancer
Bone and CancerBone and Cancer Foundation, PO Box 287452 Bone and Cancer New York, NY 10128-0025  
Toll Free: 888 862-0999 Bone and Cancer Email: bcfdn@aol.com  
Bone and Cancer

Clinical Trials

Differin (adapalene gel) Gel, 0.1%

The following drug information is obtained from various newswires, published medical journal articles, and medical conference presentations.

Approval Status:

Approved June 1996

Specific Treatments:

acne

Therapeutic Areas

General Information

Differin Gel 0.1% has been approved for the treatment of acne. Differin Gel is a new topical prescription medication that penetrates deeply into hair follicles where it can prevent and reduce blackheads and whiteheads.

Clinical Results

In controlled clinical trials, Differin Gel was shown to effectively reduce the number and severity of acne lesions after 12 weeks of therapy. Furthermore, the subjects on Differin Gel experienced less skin dryness and skin irritation than those on topical Tretinoin Gel 0.025%. Stinging, burning, peeling, and skin redness associated with retinoid therapy have been a barrier to subjects remaining on their Tretinoin acne medication and achieving successful treatment outcomes.

Side Effects

Some adverse effects such as erythema, scaling, dryness, pruritus, and burning will occur in 10%-40% of subjects. Pruritus or burning immediately after application also occurs in approximately 20% of subjects. The following additional adverse experiences were reported in approximately 1% or less of subjects: skin irritation, burning/stinging, erythema, sunburn, and acne flares. These are most commonly seen during the first month of therapy and decrease in frequency and severity thereafter.

Mechanism of Action

Differin Gel is a synthetic retinoid analogue with advanced receptor selective activity and potent anti-inflammatory and comedolytic properties.

Literature References

Shalita, Weiss, Chalker, et al. "A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne and vulgaris: A multicentre trial." Journal of the American Academy of Dermatology. March, 1996.

 How To Order Publications:
  Glossary
  FAQ

Information About

Clinical Trials



 

 

 

 

 

 

 

 

 

 

 


 

 

 

 

 

 

 


  Copyright 2011 - The Bone and Cancer Foundation