Overview

MultiCare Health System is comprised of three adult hospitals and one pediatric hospital along with over 90 out-patient clinics and primary care providers. MultiCare employs over 500 physicians including primary care providers and specialists. A major strength of the MultiCare research program is the depth and breadth of MultiCare’s integrated health network which includes nearly limitless opportunities for research in multiple settings including in-patient and out-patient settings with both adult and pediatric populations. Also important to note is the fact that MultiCare is amongst the top 3% of institutions nationwide in regard to the utilization of electronic health records (EPIC) which allows research within the System to be fully connected within in- and out-patient facilities.

The mission of the MultiCare Health System Institute for Research & Innovation (MIRI) is to promote, foster, and sustain the highest quality, cutting edge research within the medical system thereby advancing the quality of patient care. Since 1983, MultiCare researchers have been conducting both in- and out-patient clinical trials (Phase II and III, as well as Phase I Oncology) in a wide range of therapeutic areas. Our staff includes 15 full time, experienced coordinators and research assistants to include a tenured RN, six Medical Assistants, seven certified clinical research coordinators, a full-time regulatory document specialist, a senior PharmD, and certified physician investigator research supervisor, and a research manager. We work with a host of experienced investigators specializing in a variety of therapeutic areas. MultiCare maintains a 24-hour pharmacy, lab, and radiology services.

Recognizing the importance of expedient study start-up, we are able to work with central IRBs and are committed to a swift contract and budget review. All budgets and contracts are reviewed concurrently with IRB review. We pride ourselves in our ability to expedite study commencement and provide exceptional research staff.

Experience

MultiCare Health System has been conducting research since 1983. MultiCare researchers have been engaged in the following types of clinical research:

• Anesthesiology
• Cardiology
• Cardiothoracic Surgery
• Emergency Medicine
• Endocrinology & Metabolism
• Gastroenterology
• General Surgery
• Gynecologic Surgery
• Hematology
• Infectious Disease
• Internal Medicine
• Interventional Radiology
• Medical Oncology
• Phase I Oncology
• Pulmonology
• Neurology
• Pediatric
• Urology
• Women's Health

We have partnered with the following Sponsors and CROs:

• Abbott Labs
• Abbott Vascular Inc.
• Accelerated Community Oncology Research Network, Inc. (ACORN)
• Accuray, Inc
• Allergan Sales, LLC
• Allergy Therapeutics
• Amgen, Inc.
• Anthera Pharmaceuticals
• AP Pharma
• AstraZeneca Pharmaceuticals LP
• Asubio
• Aveo Pharmaceuticals, Inc.
• Averion
• Bayer HealthCare Pharmaceuticals Inc.
• Beardsworth
• Berlex, Inc.
• Biogen-Idec
• Boehringer Ingelheim Pharmaceuticals, Inc.
• Boston Scientific Corporation
• Bristol-Myers Squibb Company
• C5Research
• Celgene Corporation
• Cell Therapeutics, Inc.
• Cephalon
• Cerexa
• Clinimetrics
• Covance
• CTMS Trial Management Reporting
• Daiichi Sankyo, Inc.
• Dey Pharmaceuticals
• Duke University Clinical Research Institute
• Eisai Inc.
• EMD Serono, Inc.
• Forest Laboratories, Inc.
• Fred Hutchinson Cancer Research Center
• Genentech, Inc.
• GlaxoSmithKline
• Globus Medical, Inc.
• HeartFlow, Inc.
• Hoffmann-La Roche Inc.
• ICON (Novelos)
• Ingenix Pharmaceutical Services, Inc.
• Innocoll
• Insys Therapeutics, Inc.
• Johnson & Johnson Pharmaceutical Research & Development, LLC
• Kendle International Inc.
• Lilly USA, LLC
• Market Strategies, Inc.
• MDS Pharma
• Medical Carbon Research Institute, LLC
• Medical University of South Carolina
• Medicines Co
• Medicure
• Medifacts
• MedPace Inc.
• Medtronic Vascular, Inc.
• Merck & Co.
• Micro Therapeutics, Inc. dba ev3 Neurovascular
• Novartis Pharmaceuticals Corporation
• Novo Nordisk
• Ockham Development
• Omnicare
• Otsuka Laboratories
• Outcome Sciences, Inc.
• Pacira Pharmaceuticals, Inc.
• Parexel International, LLC
• Partners
• Peninsula Pharmaceuticals
• Pfizer
• PharmaNet, LLC
• Pharmatech Oncology, Inc.
• PPD Development, LP
• PRA International
• Premier Research
• Roche
• Roxane Laboratories
• Quintiles / Innovex
• Sanofi Aventis
• Sapphire Therapeutics dba Rejuvenon
• Schering Corporation / Merck
• Scios, Inc.
• Seattle Genetics, Inc.
• SkyePharma Inc.
• STA-4783
• Sunovion Pharmaceuticals, Inc.
• Synchronicity
• Takeda Pharmaceuticals
• Telik Inc
• Teva Pharmaceutical Products R&D, Inc.
• The Brigham and Women's Hospital, Inc.
• Tranzyme Pharmaceuticals
• United Biosource
• University of Massachusetts
• University of Washington
• William Beaumont Hospital (PAMI Coordinating Center)
• Worldwide Clinical Trials
• XenoPort

Facility

MultiCare offers both in-patient and out-patient facilities to include three adult hospitals, one pediatric hospital, and numerous primary care and specialty clinics. The Institute's primary office is located at 314 Martin Luther King, Jr Way, Suite 402, Tacoma, Washington. We are just steps away from Tacoma General and Mary Bridge Children's Hospitals. We also occupy office space and exam rooms within six out-patient specialty clinics located throughout the Puget Sound area and at Good Samaritan Hospital in Puyallup.

The following equipment/systems are available within the MultiCare Institute for Research & Innovation for use in our clinical studies:

• Locked room for investigational product with restricted access
• Phlebotomy areas
• Centrifuge
• Dedicated Research Refrigerators
• Urine processing area
• -20 Freezer
• -70 Freezer
• Access to Dry Ice
• ECG machines
• Crash Cart
• Refrigerated centrifuge
• Fax Machine, Copier, Internet Explorer 6.0 and higher
• Dedicated private work space for monitors

Patients

MultiCare Health System patients represent a diverse population in ethnicity, age, race, and sociodemographics.

Other

While MultiCare Health Systems maintains its own IRB, the MultiCare Institute for Research & Innovation is free to utilize the services of the Sponsor's central IRB to promote swift study execution. Additionally, at the present time, MultiCare does not require review by a scientific review committee prior to submission to the central IRB.