We use cookies to provide you with a better experience. By clicking the Accept button, you are agreeing to our use of cookies in accordance with our Privacy Policy.
  • Patient Resources
    • Clinical Trials
    • Search Clinical Trials
    • Patient Notification System
    • What is Clinical Research?
    • Volunteering for a Clinical Trial
    • Understanding Informed Consent
    • Useful Resources
    • FDA Approved Drugs
    • Glossary
  • Professional Resources
    • Research Center Profiles
    • Industry Provider Profiles
    • Market Research
    • FDA Approved Drugs
    • Training Guides
    • Books
    • Events
    • Newsletters
    • JobWatch
    • White Papers
    • Patient Education
    • SOPs
  • About Us
  • Contact Us
  • Advertise
  • Sign In
  • Create Account
  • Sign Out
  • My Account
Home » Directories » FDA Approved Drugs » Zelnorm (tegaserod maleate) Tablets

  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

Zelnorm (tegaserod maleate) Tablets

  • Profile

Profile

Contact Information

Currently Enrolling Trials

    Show More

    General Information

    Zelnorm aids in the movement of stools through the bowels by selectively activating 5HT4 receptors present throughout the gastrointestinal tract. Zelnorm has been approved by the FDA for the short-term treatment of women who have irritable bowel syndrome (IBS) with constipation as their main symptom. Other problems associated with IBS include abdominal pain and bloating. Although Zelnorm treats the symptoms of IBS, it is not a cure for the disorder.

    Clinical Results

    Three multicenter, double blind, placebo-controlled studies evaluated Zelnorm in 2,470 women with irritable bowel syndrome (IBS) symptoms, namely abdominal pain, bloating and constipation. Two studies were fixed dose studies and the third was a dose-titration study. In all three studies Zelnorm was administered for 12 weeks and efficacy was evaluated based on patients' ratings of their relief of symptoms and the intensity of symptoms. Zelnorm-treated patients reported greater relief from symptoms and greater increase in number of stools than placebo-treated patients, with the difference being largest during the first four weeks.

    Side Effects

    Adverse events associated with the use of Zelnorm (tegaserod maleate) may include (but are not limited to) the following:


    • Abdominal pain
    • Diarrhea
    • Nausea
    • Flatulence
    • Headache
    • Dizziness
    • Back pain
    • Influenza-like symptoms

    Mechanism of Action

    Tegaserod is a partial agonist that binds with high affinity at human 5-HT4 receptors, whereas it has no appreciable affinity for 5-HT3 or dopamine receptors. It has moderate affinity for 5-HT1 receptors. Tegaserod, by acting as an agonist at neuronal 5-HT4 receptors, triggers the release of further neurotransmitters such as calcitonin gene-related peptide from sensory neurons. The activation of 5-HT4 receptors in the gastrointestinal tract stimulates the peristaltic reflex and intestinal secretion, as well as inhibits visceral sensitivity (From FDA Label).

    Additional Information

    For additional information on Zelnorm, please visit www.zelnorm.com.

    Approval Date: 2002-07-01
    Date Created: 2002-08-07 12:00:00
    Company Name: Novartis
    Back to Listings

    Upcoming Events

    • 09Dec

      The Age of eSource: Modernizing Clinical Trials

    • 16Dec

      Master the Regulatory Pathway for Cell & Gene Therapy Submissions: Strategies for Successful BLAs

    Featured Products

    • Regenerative-medicine-steps-to-accelerate-development-pdf

      Regenerative Medicine: Steps to Accelerate Development — PDF

    • Clinical-trial-agreements-a-guide-to-key-words-and-phrases-pdf

      Clinical Trial Agreements: A Guide to Key Words and Phrases — PDF

    Featured Stories

    • Patient-phsyician-consultation

      Giving Patients Back Their Voice in Clinical Trials

    • Ich_logo

      ICH Overhauls 22-Year-Old Clinical Studies Guideline

    • Survey_chart2019

      Sponsors, CROs Doing Better, Sites Say, But More Work Is Needed

    New!

    2019 Site Survey Reports

    Learn More Here
    • About Us
    • Contact Us
    • Privacy Policy

    Footer Logo

    300 N. Washington St., Suite 200, Falls Church, VA 22046, USA

    Phone 617.948.5100 – Toll free 866.219.3440

    Copyright © 2019. All Rights Reserved. Design, CMS, Hosting & Web Development :: ePublishing