Posicor (mibefradil), a calcium channel blocker, will be available in 50 mg and 100 mg tablets for treatment of chronic stable angina pectoris and hypertension. Posicor is approved for use by itself or in combination with other antihypertensive or anti-anginal agents.
Posicor is contraindicated for use with astemizole, terfenadine and cisapride because it is metabolized by the cytochrome P450 2D6 isoenzyme. It can be life-threatening when used in conjunction with agents metabolized by P450.
Mibefradil, a subtype calcium channel blocker, blocks both low and high voltage calcium channels with greater selectivity for low voltage or Type T channels. While decreasing blood pressure, Posicor doesn’t lessen heart contractions, unlike beta blockers.