General Information

PhosLo (calcium acetate) is a phosphate binder.

PhosLo is specifically indicated for the reduction of serum phosphorus in patients with end stage renal disease.

PhosLo is supplied as a gelcap. Starting dose is 2 gelcaps with each meal. Titrate the dose every 2-3 weeks until acceptable serum phosphorus level is reached. Most patients require 3-4 gelcaps with each meal.

Mechanism of Action

PhosLo (calcium acetate) binds to the phosphate taken in through one's diet to form insoluble calcium phosphate. This is then excreted from the body without being absorbed.

Side Effects

Adverse events associated with the use of PhosLo capsules or gelcaps may include (but are not limited to) the following:

• Nausea
• Constipation
• Vomiting
• Stomach pains
• Anorexia

Clinical Trial Results

Studies have confirmed that using calcium acetate as a phosphorus binder will control serum phosphorus levels in most dialysis outpatients.