
Periostat is indicated for use as an adjunct to scaling and root planing to promote attachment level gain and to reduce pocket depth in patients with adult periodontitis.
This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.
Doxycycline has been shown to inhibit collagenase activity in vitro. Additional studies have shown that doxycycline reduces the elevated collagenase activity in the gingival crevicular fluid of patients with adultperiodontitis. The clinical significance of these findings is not known.
1.
Golub L.M., Sorsa T., Lee H-M., Ciancio S., Sorbi D., Ramamurthy
N.S., Gruber B., Salo T., Konttinen Y.T.: Doxycycline Inhibits
Neutrophil (PMN)-type Matrix Metalloproteinases in Human Adult
Periodontitis Gingiva. J. Clin. Periodontol 1995; 22: 100-109.
2.
Golub L.M., Ciancio S., Ramamurthy N.S., Leung M., McNamara T.F.:
Low-dose Doxycycline Therapy: Effect on Gingival and Crevicular
Fluid Collagenase Activity in Humans. J. Periodont Res 1990; 25:
321-330
3.
Golub L.M., Lee H.M., Greenwald R.A., Ryan M.E., Salo T.,
Giannobile W.V.: A Matrix Metalloproteinase Inhibitor Reduces
Bone-type Collagen Degradation Fragments and Specific Collegenases
in Gingival Crevicular Fluid During Adult Periodontitis.
Inflammation Research 1997; 46: 310-319.
4.
Saivain S., Houin G.: Clinical Pharmacokinetics of Doxycycline and
Minocycline. Clin. Pharmacokinetics 1988; 15; 355-366.
5.
Schach von Wittenau M., Twomey T.: The Disposition of Doxycycline
by Man and Dog. Chemotherapy 1971; 16: 217-228.
6.
Campistron G., Coulais Y., Caillard C., Mosser J., Pontagnier H.,
Houin G.: Pharmacokinetics and Bioavailability of Doxycycline in
Humans. Arzneimittel Forschung 1986; 36: 1705-1707.