Marplan is indicated for the treatment of depression. Because of its potentially serious side effects, it is not recommended as an anti-depressant of first choice in the treatment of newly diagnosed depressed patients.
The effectiveness of Marplan for long-term use, meaning longer than 6 weeks, has not been fully evaluated by trials.
Marplan can cause serious side effects. It is not recommended as initial therapy but should be reserved for patients who have not responded satisfactorily to other anti-depressants.
Some side effects include: headaches, palpitation, neck stiffness, nausea or vomiting, sweating (fevers or clammy skin), photophobia, tachycardia, bradycardia, constricting chest pain, dilated pupils, intracranial bleeding and increased blood pressure.