Lamisil Solution has been approved for the treatment of interdigital-type pedis (athlete's foot), tinea cruris (jock itch) and tinea corporis (ringworm) due to Trichophyton rubrum, Trichophyton mentagrophytes and Epidermophyton floccosum. This product contains the same prescription-strength medication as in the Lamilsi Cream. Both products have been approved for over-the-counter sales for the above indications. Lamisil Solution is also available as prescription-only for the indication of tinea versicolor.
Lamisil is a one week treatment, whereas most or all other over-the-counter (OTC) treatments for athlete's foot and other fungal infections are four week treatments. The product should be applied once daily for the treatment of tinea corporis and tinea cruris, and twice daily for the treatment of tinea pedis and tinea versicolor.
All of these fungal conditions are contagious. Good hygiene, keeping skin dry, and protecting minor skin injuries can all help prevent the spread of these fungal infections.
Other products with the Lamisil name:
In clinical studies, the Lamisil Solution treatment was investigated versus placebo, for each of the indications. Results showed that at both the end of the one-week treatment period and at the end of the study (8 weeks), patients treated with Lamisil Solution achieved much better effective treatment and complete cure results than did the patients treated with the placebo.
Adverse reactions reported by Lamisil Solution-treated patients during clinical studies:
0.2% or the 898 patients participating in clinical trials discontinued therapy due to adverse reactions.
Lamisil Solution is not for ophthalmic, oral, or intravaginal use.
Terbinafine hydrochloride is a synthetic allylamine derivative. Terbinafine hydrochloride is hypothesized to act by inhibiting the epoxidation of squalene, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. The allylamine derivatives, like the benzylamines, act at an earlier step in the ergosterol biosynthesis pathway than the azole class of antifungal drugs. Depending on the concentration of the drug and the fungal species tested in vitro, terbinafine hydrochloride may be fungicidal. However, the clinical significance of in vitro data is unknown. (From FDA Label)
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