• SKIP TO CONTENT
  • SKIP NAVIGATION
  • Patient Resources
    • COVID-19 Patient Resource Center
    • Clinical Trials
    • Search Clinical Trials
    • Patient Notification System
    • What is Clinical Research?
    • Volunteering for a Clinical Trial
    • Understanding Informed Consent
    • Useful Resources
    • FDA Approved Drugs
  • Professional Resources
    • Research Center Profiles
    • Clinical Trial Listings
    • Market Research
    • FDA Approved Drugs
    • Training Guides
    • Books
    • Events
    • Newsletters
    • JobWatch
    • White Papers
    • Patient Education
    • SOPs
    • eCFR and Guidances
  • White Papers
  • Trial Listings
  • Advertise
  • COVID-19
  • iConnect
  • Sign In
  • Create Account
  • Sign Out
  • My Account
Home » Directories » FDA Approved Drugs » Kytril (granisetron) tablets

AND
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

Kytril (granisetron) tablets

  • Profile

Profile

Contact Information

Currently Enrolling Trials

    Show More

    General Information

    A single 2 mg dose of Kytril (granisetron hydrochloride) has been approved for the treatment of nausea and vomiting associated with chemotherapy. Until now, the recommended dosage for Kytril tablets was one 1 mg tablet administered anytime within one hour before chemotherapy and a second 1 mg tablet 12 hours after the first. Now cancer patients can take Kytril tablets either once or twice daily to prevent nausea and vomiting associated with chemotherapy. Kytril, which is a 5-HT (subscript 3) receptor antagonist, is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy, including high-dose cisplatin.

    Clinical Results

    This labeling change was based in part on results from a double-blind multicenter trial in which 697 patients were randomized to receive either a single 2 mg dose of Kytril tablets or one 1 mg Kytril tablet one hour prior to chemotherapy and another 1 mg tablet 12 hours after the first tablet was given. Investigators evaluated the percentage of patients who achieved a complete response (no vomiting, no moderate or severe nausea and no rescue medication) and the incidence of emesis and nausea. Patients receiving a single 2 mg dose of Kytril tablets achieved a 64 percent response rate versus 69 percent for patients receiving Kytril tablets twice daily. This difference was not statistically significant.

    Side Effects

    Kytril tablets are well tolerated. The most frequently reported adverse events are headache, asthenia and constipation.

    Approval Date: 1997-11-01
    Company Name: SmithKline Beecham
    Back to Listings

    Upcoming Events

    • 26Jan

      Reducing Complexity in Starting Clinical Trials – More Patients, Faster Startup

    • 27Jan

      Medical Device Clinical Trials in China: Latest Regulatory Developments

    • 11Feb

      Lab X.0: Addressing Quality and Compliance Challenges in Laboratory Operations in the COVID-19 All-Digital Era

    • 23Mar

      Data Integrity for GCP Professionals: Core Requirements, Expectations and Challenges

    • 26Apr

      MAGI's Clinical Research vConference — Spring 2021

    Featured Products

    • Regenerative Medicine – Steps to Accelerate Development : PDF

      Regenerative Medicine: Steps to Accelerate Development

    • Clinical Trial Agreements — A Guide to Key Words and Phrases : PDF

      Clinical Trial Agreements: A Guide to Key Words and Phrases

    Featured Stories

    • Virtual Doctoer

      Simple Changes Can Make Trials More Patient Friendly

    • Drug approval

      Two-Thirds of Trial Subjects for Drug Approvals Are Outside the U.S.

    • VaccinewithNeedle-360x240.png

      Rules of Vaccine Approval May Be Changing, But Statistical Analysis Tools Remain Constant

    • AskTheExperts-360x240.png

      Ask the Experts: Trial Operations Adjustments in a Remote World

    Standard Operating Procedures for Risk-Based Monitoring of Clinical Trials

    The information you need to adapt your monitoring plan to changing times.

    Learn More Here
    • About Us
    • Contact Us
    • Privacy Policy
    • Do Not Sell My Personal Information

    Footer Logo

    300 N. Washington St., Suite 200, Falls Church, VA 22046, USA

    Phone 617.948.5100 – Toll free 866.219.3440

    Copyright © 2021. All Rights Reserved. Design, CMS, Hosting & Web Development :: ePublishing